Featured Articles

Feature Identification Framework for Back Injury Risk in Repetitive Work with Application in Sheep Shearing 789 444 IEEE Transactions on Biomedical Engineering (TBME)

Feature Identification Framework for Back Injury Risk in Repetitive Work with Application in Sheep Shearing

We developed an unsupervised feature selection framework for back injury risk using data collected from Australian sheep shearers. Our framework identifies features in line with literature and outperforms general methods.

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Smart Artificial Soft Tissue – Application to a Hybrid Simulator for Training of Laryngeal Pacemaker Implantation 789 444 IEEE Transactions on Biomedical Engineering (TBME)

Smart Artificial Soft Tissue – Application to a Hybrid Simulator for Training of Laryngeal Pacemaker Implantation

To facilitate the development of new hybrid surgical simulators, a framework for tool position recognition on soft synthetic tissue-like materials is being developed and applied to a laryngeal pacemaker electrode placement simulator.

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Comparison of Propagation Models and Forward Calculation Methods on Cellular, Tissue and Organ Scale Atrial Electrophysiology 789 444 IEEE Transactions on Biomedical Engineering (TBME)

Comparison of Propagation Models and Forward Calculation Methods on Cellular, Tissue and Organ Scale Atrial Electrophysiology

This study validates massively faster simulation models for computing the atrial electrocardiogram as an enabler for large-scale simulation studies and machine learning on synthetic or hybrid datasets.

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Enhancing Tissue Impedance Measurement through Modeling of Fluid Flow During Viscoelastic Relaxation 789 444 IEEE Transactions on Biomedical Engineering (TBME)

Enhancing Tissue Impedance Measurement through Modeling of Fluid Flow During Viscoelastic Relaxation

This work proposes a model based on differential equations accounting for fluid outflow in tissue under deformation and its impact on impedance measurements used for cancerous tissue differentiation.

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Designing Custom Mechanics in Running-Specific Prosthetic Feet via Shape Optimization 789 444 IEEE Transactions on Biomedical Engineering (TBME)

Designing Custom Mechanics in Running-Specific Prosthetic Feet via Shape Optimization

We employ a custom shape optimization to generate prosthetic running foot geometries given desired endpoint mechanics, and test how three new foot designs affect knee kinetics in an amputee athlete

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A novel non-invasive intervention for removing occlusions from shunts using an abrading magnetic microswarm 788 446 IEEE Transactions on Biomedical Engineering (TBME)

A novel non-invasive intervention for removing occlusions from shunts using an abrading magnetic microswarm

This paper presents a non-invasive approach to removing the shunt deposition. The method involves using collectively controlled magnetic nanoparticles (microswarm) guided by an external magnetic field.

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Direct Visualization and Quantitative Imaging of Small Airway Anatomy In Vivo Using Deep Learning Assisted Diffractive OCT 795 411 IEEE Transactions on Biomedical Engineering (TBME)

Direct Visualization and Quantitative Imaging of Small Airway Anatomy In Vivo Using Deep Learning Assisted Diffractive OCT

This is the first study to demonstrate direct visualization and automated quantification of 3D subsurface microstructures in small airways in vivo with a novel deep-learning assisted diffractive optical coherence tomography.

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Ex vivo evaluation of a minimally invasive approach for cochlear implant surgery 789 444 IEEE Transactions on Biomedical Engineering (TBME)

Ex vivo evaluation of a minimally invasive approach for cochlear implant surgery

We developed a new micro-stereotactic targeting system dedicated to cochlear implant surgery and demonstrated sufficient accuracy and the feasibility of the whole concept.

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Cooperative Hand Therapy via a Soft, Wearable, and Unilateral Telerobotic System 789 444 IEEE Transactions on Biomedical Engineering (TBME)

Cooperative Hand Therapy via a Soft, Wearable, and Unilateral Telerobotic System

This study introduces a soft wearable telerobotic system for hand therapy that enables real-time physical feedback from the therapist for actively correcting distorted grasping posture and force of stroke survivors.

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Diagnosis of skin vascular complications revealed by time-frequency analysis and laser Doppler spectrum decomposition 789 444 IEEE Transactions on Biomedical Engineering (TBME)

Diagnosis of skin vascular complications revealed by time-frequency analysis and laser Doppler spectrum decomposition

We introduce a new signal processing approach for the decomposition of laser Doppler flowmetry power spectra in terms of ranges of blood flow distribution by frequency series.

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Integrated Ultrasound and Photoacoustic-guided Laser Ablation Theranostic Endoscopic System 789 444 IEEE Transactions on Biomedical Engineering (TBME)

Integrated Ultrasound and Photoacoustic-guided Laser Ablation Theranostic Endoscopic System

A novel photoacoustic-guided theranostic Intracardiac endoscopic system was designed and developed. The developed system offers significant advantages, such as accurate monitoring of thermal lesion formation and real-time thermometry.

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Emulator-Based Optimization of a Semi-Active Hip Exoskeleton Concept: Sweeping Impedance Across Walking Speeds 782 430 IEEE Transactions on Biomedical Engineering (TBME)

Emulator-Based Optimization of a Semi-Active Hip Exoskeleton Concept: Sweeping Impedance Across Walking Speeds

This is the first study to optimize semi-active hip exoskeleton assistance across walking speeds to reduce metabolic cost. We found personalization is important and online tuning can focus on minimizing local muscle activity.

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A Robotic System with Embedded Open Microfluidic Chip for Automatic Embryo Vitrification 780 435 IEEE Transactions on Biomedical Engineering (TBME)

A Robotic System with Embedded Open Microfluidic Chip for Automatic Embryo Vitrification

In this work, we report a robotic system to automatically conduct the embryo vitrification process including the pretreatment with CPAs, transfer of single embryo to the Cryotop and cryopreservation with LN2.

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From skin mechanics to tactile neural coding: Predicting afferent neural dynamics during active touch and perception 1849 925 IEEE Transactions on Biomedical Engineering (TBME)

From skin mechanics to tactile neural coding: Predicting afferent neural dynamics during active touch and perception

This is the first study to predict the group response of the afferent tactile signals under active touch, and this study presents the possibility of using FE based integrated numerical model as a novel method to investigate the human sensorimotor mechanisms.

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Simultaneous quantification of ankle, muscle, and tendon impedance in humans 1562 929 IEEE Transactions on Biomedical Engineering (TBME)

Simultaneous quantification of ankle, muscle, and tendon impedance in humans

We developed a novel in vivo measurement technique, the first method capable of measuring muscle and tendon contributions to joint impedance simultaneously in humans.

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Intravascular Tracking of Micro-Agents Using Medical Ultrasound: Towards Clinical Applications 789 444 IEEE Transactions on Biomedical Engineering (TBME)

Intravascular Tracking of Micro-Agents Using Medical Ultrasound: Towards Clinical Applications

This study demonstrates intravascular micro-agent visualization by utilizing robotic ultrasound-based tracking and visual servoing in clinically-relevant scenarios (using biological tissue, simulation of physiological movement and fluid flow through the vessels).

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Understanding the Role of Magnetic and Magneto-Quasistatic Fields in Human Body Communication 789 444 IEEE Transactions on Biomedical Engineering (TBME)

Understanding the Role of Magnetic and Magneto-Quasistatic Fields in Human Body Communication

Viability of magnetic field based Human Body Communication (M-HBC) is explored through simulation and experiments with multiple M-HBC modes, and their comparison with electric field based Human Body Communication.

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Electromechanical Characterization of Human Brain Tissues: A Potential Biomarker for Tumor Delineation 789 444 IEEE Transactions on Biomedical Engineering (TBME)

Electromechanical Characterization of Human Brain Tissues: A Potential Biomarker for Tumor Delineation

The study demonstrates that simultaneous electromechanical characterization of brain tumors and normal brain tissues can be an effective biomarker for tumor delineation, grading, and studying heterogeneity between the brain regions.

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Electrically Small Circularly Polarized UWB Intraocular Antenna System for Retinal Prosthesis 803 627 IEEE Transactions on Biomedical Engineering (TBME)

Electrically Small Circularly Polarized UWB Intraocular Antenna System for Retinal Prosthesis

This article presents the design of an electrically small circularly polarized 3 × 3 mm2 antenna system, as an intraocular unit for retinal prosthesis, which can offer a high data-rate to generate artificial vision.

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Efficient Bone Conduction Hearing Device with a Novel Piezoelectric Transducer Using Skin as an Electrode 2560 1413 IEEE Transactions on Biomedical Engineering (TBME)

Efficient Bone Conduction Hearing Device with a Novel Piezoelectric Transducer Using Skin as an Electrode

The novel piezoelectric transducer using skin as an electrode elicited efficient bone conduction hearing with low pressure on the skin. It can be used for intractable conductive hearing loss.

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Comparison of sonication patterns and microbubble administration strategies for focused ultrasound-mediated large-volume drug delivery 1044 594 IEEE Transactions on Biomedical Engineering (TBME)

Comparison of sonication patterns and microbubble administration strategies for focused ultrasound-mediated large-volume drug delivery

This study compared different sonication patterns and microbubble administration strategies and identified the approach to achieve efficient, homogeneous, and safe large volume blood-brain barrier opening at the brainstem of mice.

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Micro-bubble F-P cavity and FBG Cascade Structure-based Pressure Sensor with Temperature Self-compensation for Minimally Invasive Surgery 789 444 IEEE Transactions on Biomedical Engineering (TBME)

Micro-bubble F-P cavity and FBG Cascade Structure-based Pressure Sensor with Temperature Self-compensation for Minimally Invasive Surgery

A high-sensitivity pressure sensor for physiological pressure measurement through a cascade structure of micro-bubble F-P cavity and FBG has been proposed, which is suitable to monitor in minimally invasive surgery.

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Transcranial Focused Ultrasound Stimulation of Periaqueductal Gray for Analgesia 789 444 IEEE Transactions on Biomedical Engineering (TBME)

Transcranial Focused Ultrasound Stimulation of Periaqueductal Gray for Analgesia

The transcranial focused ultrasound (tFUS) stimulation can achieve the effect of analgesia, and provides new insights into the development of non-invasive analgesic technology in the future.

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Global Sensitivity Analysis of Four Chamber Heart Hemodynamics Using Surrogate Models 789 444 IEEE Transactions on Biomedical Engineering (TBME)

Global Sensitivity Analysis of Four Chamber Heart Hemodynamics Using Surrogate Models

This is the first study demonstrating the feasibility of Gaussian Process Emulators as surrogate models for performing global sensitivity analysis of human blood flow in the heart.

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Artificial Intelligence Enables Real-Time and Intuitive Control of Prostheses via Nerve Interface 789 444 IEEE Transactions on Biomedical Engineering (TBME)

Artificial Intelligence Enables Real-Time and Intuitive Control of Prostheses via Nerve Interface

This article demonstrates and evaluates the performance of an artificial intelligence motor decoder using neural signals recorded from the residual peripheral nerves of amputees to control neuroprostheses in real-time for long-term uses.

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Removal of Transcranial Alternating Current Stimulation EEG Artifacts Using Blind Source Separation and Wavelets 789 444 IEEE Transactions on Biomedical Engineering (TBME)

Removal of Transcranial Alternating Current Stimulation EEG Artifacts Using Blind Source Separation and Wavelets

This study proposes a novel, combined method to clean EEG data collected during transcranial alternating current stimulation (tACS), making it possible to investigate the effects of tACS on EEG signals.

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An Occupational Shoulder Exoskeleton Reduces Muscle Activity and Fatigue During Overhead Work 789 444 IEEE Transactions on Biomedical Engineering (TBME)

An Occupational Shoulder Exoskeleton Reduces Muscle Activity and Fatigue During Overhead Work

The passive shoulder Exo4Work exoskeleton provides one-third of the arm’s gravitational torque, and reduces anterior deltoid activity and fatigue during overhead work. The hindrance during non-overhead tasks was minimized.

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Visualization of Human Skeletal Muscle Mechanical Anisotropy by Using Dual-Direction Shear Wave Imaging 789 444 IEEE Transactions on Biomedical Engineering (TBME)

Visualization of Human Skeletal Muscle Mechanical Anisotropy by Using Dual-Direction Shear Wave Imaging

This is the first study to visualize the mechanical anisotropy of human skeletal muscle by the new proposed dual-direction shear wave imaging mechanism.

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An EMG-Assisted Muscle-Force Driven Finite Element Analysis Pipeline to Investigate Joint- and Tissue-Level Mechanical Responses in Functional Activities: Towards a Rapid Assessment Toolbox 788 444 IEEE Transactions on Biomedical Engineering (TBME)

An EMG-Assisted Muscle-Force Driven Finite Element Analysis Pipeline to Investigate Joint- and Tissue-Level Mechanical Responses in Functional Activities: Towards a Rapid Assessment Toolbox

This study established an electromyography-assisted neuromusculoskeletal rigid-body and finite element modeling pipeline enabled for large cohorts studies, encouraging further research to investigate the pipeline’s potential for personalized treatment-planning of knee osteoarthritis.

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A Handheld Steerable Surgical Drill With a Novel Miniaturized Articulated Joint Module for Dexterous Confined-Space Bone Work 789 444 IEEE Transactions on Biomedical Engineering (TBME)

A Handheld Steerable Surgical Drill With a Novel Miniaturized Articulated Joint Module for Dexterous Confined-Space Bone Work

This article presents a handheld steerable drill with a 4.5-mm miniaturized tip capable of bending 65 degrees to minimize collateral tissue damage to patients for a better clinical outcome.

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O-pH: Optical pH Monitor to Measure Dental Biofilm Acidity and Assist in Enamel Health Monitoring 2008 1220 IEEE Transactions on Biomedical Engineering (TBME)

O-pH: Optical pH Monitor to Measure Dental Biofilm Acidity and Assist in Enamel Health Monitoring

O-pH measures dental biofilm’s acidity by capturing fluorescence of Sodium Fluorescein, an FDA approved chemical dye, and provides quantitative feedback to assist in oral health monitoring.

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HAILO: A Sensorised Hand Splint for the Exploration of Interface Forces 776 444 IEEE Transactions on Biomedical Engineering (TBME)

HAILO: A Sensorised Hand Splint for the Exploration of Interface Forces

This study presents a wearable device for the monitoring of pressure and shear interaction between the hand and a thumb splint, enabling the assessment of disease characteristics in hand arthritis.

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Knock-in of a Large Reporter Gene via the High-Throughput Microinjection of the CRISPR/Cas9 System 780 435 IEEE Transactions on Biomedical Engineering (TBME)

Knock-in of a Large Reporter Gene via the High-Throughput Microinjection of the CRISPR/Cas9 System

This work demonstrates the microinjection of CRISPR/Cas9 with an enhanced green fluorescent protein (GFP) donor template into single HepG2 cells can achieve reporter gene knock-in targeting the adeno-associated virus site 1 locus. Homology-directed repair-mediated knock-in can be observed with an efficiency of 41%. Assessment via T7E1 assay indicates that the GFP knock-in cells exhibit no detectable changes at potential off-target sites. A case study of injecting the GFP knock-in cells into zebrafish (Danio rerio) embryos to form an in vivo tumor model is conducted. Results demonstrate the efficiency of combining microinjection with the CRISPR/Cas9 system in achieving gene knock-in.

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