IEEE Transactions on

Biomedical Engineering

IEEE Transactions on Biomedical Engineering contains basic and applied papers dealing with biomedical engineering. Papers range from engineering development in methods and techniques with biomedical applications to experimental and clinical investigations with engineering contributions.

Editor-in-Chief

Xiaochuan Pan

Xiaochuan Pan

Xiaochuan Pan is currently Professor of Radiology, Radiation & Cellular Oncology, Committee in Medical Physics, the College, and the University of Chicago Medicine Comprehensive Cancer Center at The University of Chicago. He received the BS (1982) and MS (1985) degrees in physics from Beijing University and the Institute of Physics, Science Academy of China and the MS (1988) and PhD (1991) degrees in physics from The University of Chicago. Following post-doc training in medical imaging from 1992-1994 in the Department of Radiology at The University of Chicago, he was appointed as an Assistant Professor of Radiology before being promoted to Associate Professor and Professor of Radiology in 2001 and 2006.

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Featured Articles

Visualization of Human Skeletal Muscle Mechanical Anisotropy by Using Dual-Direction Shear Wave Imaging
Visualization of Human Skeletal Muscle Mechanical Anisotropy by Using Dual-Direction Shear Wave Imaging 789 444 IEEE Transactions on Biomedical Engineering (TBME)

Visualization of Human Skeletal Muscle Mechanical Anisotropy by Using Dual-Direction Shear Wave Imaging

This is the first study to visualize the mechanical anisotropy of human skeletal muscle by the new proposed dual-direction shear wave imaging mechanism.

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An EMG-Assisted Muscle-Force Driven Finite Element Analysis Pipeline to Investigate Joint- and Tissue-Level Mechanical Responses in Functional Activities: Towards a Rapid Assessment Toolbox
An EMG-Assisted Muscle-Force Driven Finite Element Analysis Pipeline to Investigate Joint- and Tissue-Level Mechanical Responses in Functional Activities: Towards a Rapid Assessment Toolbox 788 444 IEEE Transactions on Biomedical Engineering (TBME)

An EMG-Assisted Muscle-Force Driven Finite Element Analysis Pipeline to Investigate Joint- and Tissue-Level Mechanical Responses in Functional Activities: Towards a Rapid Assessment Toolbox

This study established an electromyography-assisted neuromusculoskeletal rigid-body and finite element modeling pipeline enabled for large cohorts studies, encouraging further research to investigate the pipeline’s potential for personalized treatment-planning of knee osteoarthritis.

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A Handheld Steerable Surgical Drill With a Novel Miniaturized Articulated Joint Module for Dexterous Confined-Space Bone Work
A Handheld Steerable Surgical Drill With a Novel Miniaturized Articulated Joint Module for Dexterous Confined-Space Bone Work 789 444 IEEE Transactions on Biomedical Engineering (TBME)

A Handheld Steerable Surgical Drill With a Novel Miniaturized Articulated Joint Module for Dexterous Confined-Space Bone Work

This article presents a handheld steerable drill with a 4.5-mm miniaturized tip capable of bending 65 degrees to minimize collateral tissue damage to patients for a better clinical outcome.

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O-pH: Optical pH Monitor to Measure Dental Biofilm Acidity and Assist in Enamel Health Monitoring
O-pH: Optical pH Monitor to Measure Dental Biofilm Acidity and Assist in Enamel Health Monitoring 2008 1220 IEEE Transactions on Biomedical Engineering (TBME)

O-pH: Optical pH Monitor to Measure Dental Biofilm Acidity and Assist in Enamel Health Monitoring

O-pH measures dental biofilm’s acidity by capturing fluorescence of Sodium Fluorescein, an FDA approved chemical dye, and provides quantitative feedback to assist in oral health monitoring.

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HAILO: A Sensorised Hand Splint for the Exploration of Interface Forces
HAILO: A Sensorised Hand Splint for the Exploration of Interface Forces 776 444 IEEE Transactions on Biomedical Engineering (TBME)

HAILO: A Sensorised Hand Splint for the Exploration of Interface Forces

This study presents a wearable device for the monitoring of pressure and shear interaction between the hand and a thumb splint, enabling the assessment of disease characteristics in hand arthritis.

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Knock-in of a Large Reporter Gene via the High-Throughput Microinjection of the CRISPR/Cas9 System 780 435 IEEE Transactions on Biomedical Engineering (TBME)

Knock-in of a Large Reporter Gene via the High-Throughput Microinjection of the CRISPR/Cas9 System

This work demonstrates the microinjection of CRISPR/Cas9 with an enhanced green fluorescent protein (GFP) donor template into single HepG2 cells can achieve reporter gene knock-in targeting the adeno-associated virus site 1 locus. Homology-directed repair-mediated knock-in can be observed with an efficiency of 41%. Assessment via T7E1 assay indicates that the GFP knock-in cells exhibit no detectable changes at potential off-target sites. A case study of injecting the GFP knock-in cells into zebrafish (Danio rerio) embryos to form an in vivo tumor model is conducted. Results demonstrate the efficiency of combining microinjection with the CRISPR/Cas9 system in achieving gene knock-in.

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