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Visualization of Human Skeletal Muscle Mechanical Anisotropy by Using Dual-Direction Shear Wave Imaging

Visualization of Human Skeletal Muscle Mechanical Anisotropy by Using Dual-Direction Shear Wave Imaging

Visualization of Human Skeletal Muscle Mechanical Anisotropy by Using Dual-Direction Shear Wave Imaging 789 444 IEEE Transactions on Biomedical Engineering (TBME)
This is the first study to visualize the mechanical anisotropy of human skeletal muscle by the new proposed dual-direction shear wave imaging mechanism. read more
An EMG-Assisted Muscle-Force Driven Finite Element Analysis Pipeline to Investigate Joint- and Tissue-Level Mechanical Responses in Functional Activities: Towards a Rapid Assessment Toolbox

An EMG-Assisted Muscle-Force Driven Finite Element Analysis Pipeline to Investigate Joint- and Tissue-Level Mechanical Responses in Functional Activities: Towards a Rapid Assessment Toolbox

An EMG-Assisted Muscle-Force Driven Finite Element Analysis Pipeline to Investigate Joint- and Tissue-Level Mechanical Responses in Functional Activities: Towards a Rapid Assessment Toolbox 788 444 IEEE Transactions on Biomedical Engineering (TBME)
This study established an electromyography-assisted neuromusculoskeletal rigid-body and finite element modeling pipeline enabled for large cohorts studies, encouraging further research to investigate the pipeline’s potential for personalized treatment-planning of knee osteoarthritis. read more
A Handheld Steerable Surgical Drill With a Novel Miniaturized Articulated Joint Module for Dexterous Confined-Space Bone Work

A Handheld Steerable Surgical Drill With a Novel Miniaturized Articulated Joint Module for Dexterous Confined-Space Bone Work

A Handheld Steerable Surgical Drill With a Novel Miniaturized Articulated Joint Module for Dexterous Confined-Space Bone Work 789 444 IEEE Transactions on Biomedical Engineering (TBME)
This article presents a handheld steerable drill with a 4.5-mm miniaturized tip capable of bending 65 degrees to minimize collateral tissue damage to patients for a better clinical outcome. read more
O-pH: Optical pH Monitor to Measure Dental Biofilm Acidity and Assist in Enamel Health Monitoring

O-pH: Optical pH Monitor to Measure Dental Biofilm Acidity and Assist in Enamel Health Monitoring

O-pH: Optical pH Monitor to Measure Dental Biofilm Acidity and Assist in Enamel Health Monitoring 2008 1220 IEEE Transactions on Biomedical Engineering (TBME)
O-pH measures dental biofilm’s acidity by capturing fluorescence of Sodium Fluorescein, an FDA approved chemical dye, and provides quantitative feedback to assist in oral health monitoring. read more
HAILO: A Sensorised Hand Splint for the Exploration of Interface Forces

HAILO: A Sensorised Hand Splint for the Exploration of Interface Forces

HAILO: A Sensorised Hand Splint for the Exploration of Interface Forces 776 444 IEEE Transactions on Biomedical Engineering (TBME)
This study presents a wearable device for the monitoring of pressure and shear interaction between the hand and a thumb splint, enabling the assessment of disease characteristics in hand arthritis. read more

Knock-in of a Large Reporter Gene via the High-Throughput Microinjection of the CRISPR/Cas9 System

Knock-in of a Large Reporter Gene via the High-Throughput Microinjection of the CRISPR/Cas9 System 780 435 IEEE Transactions on Biomedical Engineering (TBME)
This work demonstrates the microinjection of CRISPR/Cas9 with an enhanced green fluorescent protein (GFP) donor template into single HepG2 cells can achieve reporter gene knock-in targeting the adeno-associated virus site 1 locus. Homology-directed repair-mediated knock-in can be observed with an efficiency of 41%. Assessment via T7E1 assay indicates that the GFP knock-in cells exhibit no detectable changes at potential off-target sites. A case study of injecting the GFP knock-in cells into zebrafish (Danio rerio) embryos to form an in vivo tumor model is conducted. Results demonstrate the efficiency of combining microinjection with the CRISPR/Cas9 system in achieving gene knock-in. read more

MRI-Guided Cardiac RF Ablation for Comparing MRI Characteristics of Acute Lesions and Associated Electrophysiologic Voltage Reductions

MRI-Guided Cardiac RF Ablation for Comparing MRI Characteristics of Acute Lesions and Associated Electrophysiologic Voltage Reductions 2560 1427 IEEE Transactions on Biomedical Engineering (TBME)
This study characterizes permanent and transient injury caused by cardiac RF ablation in a preclinical model. Native-contrast MRI features of ablation were investigated in relation to catheter-based electrophysiologic (EP) signals inherently co-registered within the same coordinate frame, and histologically validated. Specifically, we show that bipolar voltage was reduced in the presence of both the permanent T1-derived RF lesion and transient T2-derived edema. These results suggest that these regions are distinct in native-contrast MRI, but not differentiable using bipolar voltage. Intraprocedural MRI visualization distinguishing transient and permanent injury could guide creation of more complete durable RF ablations, reducing arrhythmia recurrence. read more

Quantification and 3D Localization of Magnetically Navigated Superparamagnetic Particles Using MRI in Phantom and Swine Chemoembolization Models

Quantification and 3D Localization of Magnetically Navigated Superparamagnetic Particles Using MRI in Phantom and Swine Chemoembolization Models 780 435 IEEE Transactions on Biomedical Engineering (TBME)

Author(s): Ning Li, Cyril Tous, Ivan P. Dimov, Dominic Cadoret, Phillip Fei, Yasamin Majedi, Simon Lessard, Zeynab Nosrati, Katayoun Saatchi, Urs O. Häfeli, An Tang, Samuel Kadoury, Sylvain Martel, Gilles…

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Estimating the neovascularity of human finger tendon through high-frequency ultrasound micro-Doppler imaging

Estimating the neovascularity of human finger tendon through high-frequency ultrasound micro-Doppler imaging 780 435 IEEE Transactions on Biomedical Engineering (TBME)
High-frequency micro-Doppler imaging (HFμDI) based on 40-MHz ultrafast ultrasound imaging was proposed for visualizing the neovascularization in injured finger tendons through block-wise singular value decomposition filtering and curvilinear structure enhancement. Small animal imaging experiments revealed that HFμDI provides excellent performance and the minimum vessel size was 35 μm without contrast agents. Neovascularization was clearly observed in injured finger tendons during the early phase of healing (weeks 11–21) and regressed from week 52-56. Neovascular density decreased by approximately 1.8%–8.0% after 4 weeks of rehabilitation. The experimental results indicate the potential of HFμDI for injured finger tendon evaluations. read more