Electrophysiology

Soft Nanomembrane Sensors and Flexible Hybrid Bioelectronics for Wireless Quantification of Blepharospasm

Author(s): Musa Mahmood, Shinjae Kwon, Gamze Kilic Berkmen, Yun-Soung Kim, Laura Scorr, H. A. Jinnah, Woon-Hong Yeo
Soft Nanomembrane Sensors and Flexible Hybrid Bioelectronics for Wireless Quantification of Blepharospasm 600 625 IEEE Transactions on Biomedical Engineering (TBME)
This article introduces a soft nanomembrane bioelectronic system that offers wireless, quantitative detection of blepharospasm (BL). A set of computational and experimental studies of materials and mechanics provides the fundamental design factors for the soft bioelectronics. The nanomembrane electrodes, mounted around the eyes, are capable of measuring clinical symptoms, including the frequency of blinking, the duration of eye closures, and combinations of blinking and spasms. The deep-learning algorithm offers objective, real-time classification of critical pathological features in BL. The wearable electronic system outperforms the conventional manual clinical rating, proven by a pilot study with 13 patients. read more
Epilepsy-on-a-chip System for Antiepileptic Drug Discovery

Epilepsy-on-a-chip System for Antiepileptic Drug Discovery

Author(s): Jing Liu, Anna R. Sternberg, Shabnam Ghiasvand, Yevgeny Berdichevsky
Epilepsy-on-a-chip System for Antiepileptic Drug Discovery 170 177 IEEE Transactions on Biomedical Engineering (TBME)

    Development of antiepileptic drugs is currently complicated by the long time course of epileptogenesis. This process occurs on a time scale of weeks to months in animal models, and…

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In-vivo Electrophysiological Study of Induced Ventricular Tachycardia in Intact Rat Model of Chronic Ischemic Heart Failure

In-Vivo Electrophysiological Study of Induced Ventricular Tachycardia in Intact Rat Model of Chronic Ischemic Heart Failure

Author(s): Kyle Weigand, Russell Witte, Talal Moukabary, Ike Chinyere, Jordan Lancaster, Mary Kaye Pierce, Steven Goldman, Elizabeth Juneman
In-Vivo Electrophysiological Study of Induced Ventricular Tachycardia in Intact Rat Model of Chronic Ischemic Heart Failure 170 177 IEEE Transactions on Biomedical Engineering (TBME)

Ventricular tachycardia and ventricular fibrillation are the most common causes of sudden cardiac death in patients with chronic heart failure (CHF). Furthermore, as the next generation of therapeutics for heart…

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Orientation Independent Catheter-Based Characterization of Myocardial Activation

Orientation Independent Catheter-Based Characterization of Myocardial Activation

Author(s): D. Curtis Deno, Ram Balachandran, Dennis Morgan, Faiz Ahmad, Stéphane Massé, Kumaraswamy Nanthakumar
Orientation Independent Catheter-Based Characterization of Myocardial Activation 170 177 IEEE Transactions on Biomedical Engineering (TBME)

Cardiac electrogram (EGM) signals and electrophysiologic (EP) characteristics derived from them such as amplitude and timing are central to the diagnosis and therapeutic management of arrhythmias. Bipolar EGMs are often…

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High-Resolution Electrogastrogram: A Novel, Noninvasive Method for Determining Gastric Slow-Wave Direction and Speed

High-Resolution Electrogastrogram: A Novel, Noninvasive Method for Determining Gastric Slow-Wave Direction and Speed

Author(s): Armen A. Gharibans, Sanggyun Kim, David C. Kunkel, Todd P. Coleman
High-Resolution Electrogastrogram: A Novel, Noninvasive Method for Determining Gastric Slow-Wave Direction and Speed 170 177 IEEE Transactions on Biomedical Engineering (TBME)

Although the importance of gastrointestinal (GI) health is increasingly recognized, the lack of a robust, non-invasive system for objective GI electrophysiologic assessment hinders complete understanding of the impact of GI…

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The Past, Present, and Future of Real-Time Control in Cellular Electrophysiology

The Past, Present, and Future of Real-Time Control in Cellular Electrophysiology 556 235 IEEE Transactions on Biomedical Engineering (TBME)

Jennifer A. Bauer, Katherine M. Lambert, and John A. White, Brain Institute, University of Utah Volume 61, Issue 5, Page:1448-1456 Control-based strategies have been critical for advancing our understanding of the…

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Minimizing Cytosol Dilution in Whole-Cell Patch-Clamp Experiments

Minimizing Cytosol Dilution in Whole-Cell Patch-Clamp Experiments 150 150 IEEE Transactions on Biomedical Engineering (TBME)

Samsoon Inayat, Lawrence H. Pinto, and John B. Troy Volume: 60, Issue: 7, Page(s): 2042-2051 The cell is the basic unit of life. While living, it responds to diverse internal…

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