Aorta

The Contribution of Glycosaminoglycans/Proteoglycans to Aortic Mechanics in Health and Disease: A Critical Review

Author(s): Noor M. Ghadie, Jean-Philippe St-Pierre, M.R. Labrosse
The Contribution of Glycosaminoglycans/Proteoglycans to Aortic Mechanics in Health and Disease: A Critical Review 170 177 IEEE Transactions on Biomedical Engineering (TBME)
This review summarizes the current understanding of the mechanobiological functions of glycosaminoglycans (GAGs) and proteoglycans (PGs) in the normal aortic wall, as well as their potential impact on aortic diseases such as aneurysms and dissections. We identify knowledge gaps and propose paths of inquiry in hopes of ultimately enhancing the accuracy of mathematical models of aortic mechanics, and furthering clinical guidelines and standard of care. Specifically, we describe the swelling of GAGs/PGs and discuss their potential contributions to residual stresses and aortic stiffness. We also underscore different potential roles they may play in thoracic aortic aneurysm and abdominal aortic aneurysm. read more

4-D Flow MRI-Based Computational Analysis of Blood Flow in Patient-Specific Aortic Dissection

Author(s): Selene Pirola, Baolei Guo, Claudia Menichini, Simone Saitta, Weiguo Fu, Zhihui Dong, Xiao Yun Xu
4-D Flow MRI-Based Computational Analysis of Blood Flow in Patient-Specific Aortic Dissection 354 369 IEEE Transactions on Biomedical Engineering (TBME)

       Type B aortic dissection (TBAD) is a serious clinical emergency characterized by a split in the layers of the aortic wall which allows blood to enter a second channel…

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