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dziura

Acoustic beam mapping for guiding HIFU therapy in vivo using sub-therapeutic sound pulse and passive beamforming
Acoustic beam mapping for guiding HIFU therapy in vivo using sub-therapeutic sound pulse and passive beamforming IEEE Transactions on Biomedical Engineering (TBME)
This work aims at deriving the therapeutic energy distribution within the tissue at the pre-treatment stage to guide the HIFU procedure. A beamforming-based energy mapping technique was established to estimate in-situ beam path of the therapeutic energy in a non-invasive way, which is extremely useful in visualizing the sound beam, especially its focal region, for the HIFU surgery. Effectiveness of this technique has been validated with simulations, in-vitro experiments, ex-vivo experiments and in-vivo tests on a rabbit. The technique is safe, easy to be applied in clinical practices, and can potentially be adapted to other ultrasound-related beam manipulating applications. read more

Sensitivity Analysis Highlights the Importance of Accurate Head Models for Electrical Impedance Tomography Monitoring of Intracerebral Hemorrhagic Stroke
Sensitivity Analysis Highlights the Importance of Accurate Head Models for Electrical Impedance Tomography Monitoring of Intracerebral Hemorrhagic Stroke IEEE Transactions on Biomedical Engineering (TBME)
In this study, we investigate the role of accurate head modeling in electrical impedance tomography (EIT) monitoring of intracerebral hemorrhagic stroke. We compared anatomically detailed six-layer and simplified three-layer finite element models and computed and visualized scalp potentials, lead fields and sensitivity distributions with various perturbations. In addition, inverse imaging was examined with selected cases. Our results show that detailed anatomy and realistic tissue conductivities have significant effect on the simulated measurements, the sensitivities and the EIT images reconstructed from the simulated measurement data. We conclude it’s important to consider the anatomical details such as cerebrospinal fluid in EIT research. read more

Estimating Ground Reaction Force and Center of Pressure Using Low-Cost Wearable Devices
Author(s)3: Brandon Oubre, Sunghoon Ivan Lee
Estimating Ground Reaction Force and Center of Pressure Using Low-Cost Wearable Devices IEEE Transactions on Biomedical Engineering (TBME)
Ambulatory monitoring of ground reaction force (GRF) and plantar center of pressure (CoP) could improve management of health conditions that impair mobility. This work presents a system consisting of 1) an insole instrumented with six force-sensitive resistors and 2) a string-based knee angle sensor. Supervised machine learning models estimated weight-normalized GRF and shoe size-normalized CoP, which were re-scaled to obtain GRF and CoP. Normalized models accurately estimated GRF and CoP despite deficiencies in force sensor data. Ambulatory use of the proposed system could enable objective, longitudinal monitoring of severity and progression for a variety of health conditions. read more

Gamma Power of Electroencephalogram Arousal is Modulated by Respiratory Event Type and Severity in Obstructive Sleep Apnea
Gamma Power of Electroencephalogram Arousal is Modulated by Respiratory Event Type and Severity in Obstructive Sleep Apnea IEEE Transactions on Biomedical Engineering (TBME)
This work investigated breathing obstruction-related arousal intensity via high-frequency spectral content in nocturnal electroencephalogram (EEG). Gamma band (30–40 Hz) power in EEG was studied during arousals caused by different respiratory events in 869 patients with suspected obstructive sleep apnea (OSA). Arousal gamma power was higher in deeper sleep and increased alongside the respiratory event severity. As elevated gamma activity could indicate a greater shift towards wakefulness, the results illustrate that the magnitude of sleep disruption might vary depending on the respiratory event characteristics. These findings can bring more insight into respiratory event-related sleep fragmentation in OSA severity assessment. read more

Flexible hybrid integration enabled on-skin electronics for wireless monitoring of electrophysiology and motion
Author(s)3: Jun Zhao
Flexible hybrid integration enabled on-skin electronics for wireless monitoring of electrophysiology and motion IEEE Transactions on Biomedical Engineering (TBME)
This work reports flexible hybrid integration strategies which endow the on-skin electronic system with advantages of high integration density of electric components, facile fabrication schemes, high stretchability and reliability, and soft and conformal interfaces with human skin. Based on these strategies, an on-skin flexible hybrid electronic system (FHES) is fabricated to collect human electrocardiogram (ECG) and acceleration data, wirelessly transmit and display the data in real time on a mobile phone application through Bluetooth communication. This on-skin system has great potential for applications in wearable health monitoring and physical training. read more

Acoustic holograms for bilateral blood-brain barrier opening in a mouse model
Author(s)3: thinkdm2, Elisa E. Konofagou
Acoustic holograms for bilateral blood-brain barrier opening in a mouse model IEEE Transactions on Biomedical Engineering (TBME)
Microbubble-enhanced focused ultrasound (FUS) allows the blood-brain barrier opening (BBBO) for drug delivery into the brain. However, single-element FUS technologies do not allow high-resolution, multi-focal, simultaneous targeting, in addition to distortion of the focused beam due to skull aberrations. In this work, we present the first preclinical BBBO application of acoustic holograms in mice. A 3D-printed hologram coupled to a single-element focused transducer produced two symmetric foci while compensating for the skull aberrations. T1-weighted MRI showed BBBO at two quasi-spherical spots. This work demonstrates the feasibility of hologram-assisted BBBO for low-cost and highly-localized drug delivery in a mouse brain. read more

Constructing Multi-view High-order Functional Connectivity Networks for Diagnosis of Autism Spectrum Disorder
Author(s)3: Feng Zhao, Xiangfei Zhang, Kim-Han Thung, Ning Mao, Seong-Whan Lee, Dinggang Shen
Constructing Multi-view High-order Functional Connectivity Networks for Diagnosis of Autism Spectrum Disorder 213 177 IEEE Transactions on Biomedical Engineering (TBME)
To fully explore the discriminative information provided by different brain networks, a cluster-based multi-view high-order FCN (Ho-FCN) framework is proposed in this paper. Specifically, we first group the functional connectivity (FC) time series into different clusters and compute the multi-order central moment series for the FC time series in each cluster. Then we utilize the correlation of central moment series between different clusters to reveal the high-order FC relationships among multiple ROIs. read more
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Dual-Modality Volume Measurement Integrated on a Ventricular Assist Device
Author(s)3: Leonie Korn, Seraina Anne Dual, Jöran Rixen, Mirko Meboldt, Steffen Leonhardt, Marianne Schmid Daners, Marian Walter
Dual-Modality Volume Measurement Integrated on a Ventricular Assist Device 170 177 IEEE Transactions on Biomedical Engineering (TBME)
We present an approach to robustly measure heart volumes in patients with advanced heart disease for individualized therapy after the implantation of a heart pump. Therefore, we integrate ultrasound and impedance measurement techniques on a heart pump. In this in-vitro study, we found that the dual-modality approach was as accurate as standard calibrated measurements. In contrast to established methods, the dual-modality volume measurements are valid over a wide range of heart sizes without further calibration. By combining modalities, calibration becomes obsolete, and measurement of heart volume is possible despite changes in geometry that often occur after heart pump implantation. read more

STEER: 3D Printed Guide for Nerve Regrowth Control and Neural Interface in Non-Human Primate Model
Author(s)3: Agata Blasiak, Kian Ann Ng, Marshal Dian Sheng Wong, Chne-Wuen Tsai, Astrid Rusly, Gil Gerald Lasam Gammad, Kai Voges, Camilo Libedinsky, Shih Cheng Yen, Nitish V. Thakor, Amitabha Lahiri
STEER: 3D Printed Guide for Nerve Regrowth Control and Neural Interface in Non-Human Primate Model 461 480 IEEE Transactions on Biomedical Engineering (TBME)
Our work aims to address the challenging problem of reactive-fibrosis in establishing a long term peripheral neural interface (PNI). We present a novel interface – STEER PNI – that harnessed the fibro-axonal growth from the nerve and incorporated fibrosis in its design. STEER PNI consists of a synthetic guide that steers fibro-axonal growth toward encapsulation of the electrodes incorporated within the guide itself. We validated the functionality of this interface in macaques with electrophysiology and immunohistochemistry. This design provides a practical approach for creating long term neural interfaces with applications in neuro-prosthetics and beyond. read more
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Force and Velocity Based Puncture Detection in Robot Assisted Retinal Vein Cannulation: In-vivo Study
Author(s)3: Alireza Alamdar, Niravkumar Patel, Muller Urias, Ali Ebrahimi, Peter Gehlbach, Iulian Iordachita
Force and Velocity Based Puncture Detection in Robot Assisted Retinal Vein Cannulation: In-vivo Study 400 416 IEEE Transactions on Biomedical Engineering (TBME)
Retinal vein cannulation is a technically demanding surgical procedure and its feasibility relies on using advanced surgical robots equipped with force-sensing microneedles, and reliable detection of the moment of venous puncture. This paper reports the first in-vivo retinal vein cannulation trial on rabbit eyes, using sensorized metal needles, and investigates puncture detection. We utilized total of four indices including two previously demonstrated and two new ones and improved the detection rate from 75% to 92%. The study provides promising results and the criteria developed may serve as guidelines for further investigation into puncture detection in in-vivo retinal vein cannulation. read more
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