hyperthermia

Millimeter-wave heating in vitro: local microscale temperature measurements correlated to heat shock cellular response

Author(s): Rosa Orlacchio, Denys Nikolayev, Yann Le Page, Yves Le Dréan, Maxim Zhadobov
Millimeter-wave heating in vitro: local microscale temperature measurements correlated to heat shock cellular response 170 177 IEEE Transactions on Biomedical Engineering (TBME)
Millimeter-wave (MMW) induced heating can be potentially used to treat superficial skin cancer, including spreading melanoma. The aim of this work is to assess the cellular sensitivity of the A375 melanoma cell line to continuous MMW (58.4 GHz) induced heating between 37 and 47°C. Phosphorylation of heat shock protein 27 (HSP27) was used as a marker of the heat- induced cellular stress. Numerical and experimental electromagnetic and thermal dosimetry were carried out in detail to guarantee the correct interpretation of the biological outcomes. Results obtained may contribute to the design and optimization of clinical thermal treatment of superficial melanoma. read more

A Preclinical System Prototype for Focused Microwave Breast Hyperthermia Guided by Compressive Thermoacoustic Tomography

Author(s): Jianian Li, Baosheng Wang, Dajun Zhang, Chenzhe Li, Yihui Zhu, Yi Zou, Baile Chen, Tao Wu, Xiong Wang
A Preclinical System Prototype for Focused Microwave Breast Hyperthermia Guided by Compressive Thermoacoustic Tomography 170 177 IEEE Transactions on Biomedical Engineering (TBME)
Focused microwave breast hyperthermia (FMBH) can provide accurate and cost-effective treatment of breast tumors with low side effect. A clinically feasible FMBH system requires a guidance technique to monitor the microwave power distribution in the breast. Compressive thermoacoustic tomography (CTT) is a suitable guidance approach for FMBH. We developed a preclinical system prototype for the FMBH-CTT technique, mainly containing a microwave phased antenna array and an ultrasound transducer array. Experimental results demonstrate that the CTT technique can offer reliable guidance for the entire process of FMBH, i.e., from unfocused to focused microwave power distribution. read more

Wireless Hyperthermia Stent System for Restenosis Treatment and Testing with Swine Model

Author(s): Ying Yi, Jiaxu Chen, Madeshwaran Selvaraj, York Hsiang, Kenichi Takahata
Wireless Hyperthermia Stent System for Restenosis Treatment and Testing with Swine Model 170 177 IEEE Transactions on Biomedical Engineering (TBME)

Stenting is a common approach to treating atherosclerosis, the main pathology that leads to cardiovascular disease causing thousands of death each day. Despite its proven efficacy, the long-term results of…

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Real-Time 3D Microwave Monitoring of Interstitial Thermal Therapy

Author(s): Guanbo Chen, John Stang, Mark Haynes, Eric Leuthardt, Mahta Moghaddam
Real-Time 3D Microwave Monitoring of Interstitial Thermal Therapy 170 177 IEEE Transactions on Biomedical Engineering (TBME)

Minimally invasive thermal treatments, such as microwave ablation, have emerged as safer, faster, and more precise alternatives to surgery for many soft tissue cancers, including liver and kidney. Their efficacy…

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