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Multiscale Modeling of Glioblastoma Suggests that the Partial Disruption of Vessel/Cancer Stem Cell Crosstalk Can Promote Tumor Regression without Increasing Invasiveness

Author(s): Huaming Yan, Mónica Romero-López, Hermann B. Frieboes, Christopher C. W. Hughes, John S. Lowengrub
Multiscale Modeling of Glioblastoma Suggests that the Partial Disruption of Vessel/Cancer Stem Cell Crosstalk Can Promote Tumor Regression without Increasing Invasiveness 170 177 IEEE Transactions on Biomedical Engineering (TBME)

In glioblastoma, the crosstalk between vascular endothelial cells (VECs) and glioma stem cells (GSCs) has been shown to enhance tumor growth. We develop a hybrid continuum-discrete mathematical model and show…

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