IEEE Transactions on Biomedical Engineering contains basic and applied papers dealing with biomedical engineering. Papers range from engineering development in methods and techniques with biomedical applications to experimental and clinical investigations with engineering contributions.
Intrathecal (IT) delivery is a drug administration method that bypasses the blood-brain barrier by injecting therapeutic molecules directly into the central nervous system. In vivo tracer infusion experiments performed in cynomolgus monkeys dispel the common belief that in intrathecal drug...
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Intrathecal (IT) drug administration bypasses the blood-brain barrier by injecting therapeutic molecules directly into the central nervous system. Infusion experiments demonstrate the intrathecal route as a viable method for targeting molecules to the spine or the brain. Multimodal imaging confirms that IT administration with proper infusion settings can achieve wider dispersion than has been reported previously. Validation by in vivo nonhuman primate data confirms our ability to predict the biodistribution of intrathecally administered agents from first principles. The study reinstates intrathecal administration as a promising modality for novel treatments such as enzyme replacement or gene therapies targeting neurodegenerative diseases...
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