IEEE Journal of Translational Engineering in Health and Medicine
Articles

Articles
Quantifying Tremor in Essential Tremor using Inertial Sensors — Validation of an Algorithm
Background Assessment of essential tremor is often done by a trained clinician who observes the limbs during different postures and actions and subsequently rates the tremor. While this method has been shown to be reliable, the inter- and intra-rater reliability... Read more
Articles
A Decision Support System for Diabetes Chronic Care Models based on General Practitioner engagement and EHR data sharing
Objective Decision support systems (DSS) have been developed and promoted for their potential to improve quality of health care. However, there is a lack of common clinical strategy and a poor management of clinical resources and erroneous implementation of preventive... Read more
Articles
Quantification of Resting of Resting-state Ballistocardiogram Difference between Clinical and Non-clinical Populations for Ambient Monitoring of Heart Failure
A ballistocardiogram (BCG) is a versatile bio-signal that enables ambient remote monitoring of heart failure (HF) patients in a home setting, achieved through embedded sensors in the surrounding environment. Numerous methods of analysis are available for extracting physiological information using... Read more
Articles
Side-Channel Sensing: Exploiting Side-Channels to Extract Information for Medical Diagnostics and Monitoring
Abstract Information within systems can be extracted through side-channels; unintended communication channels that leak information. The concept of side-channel sensing is explored, in which sensor data is analysed in non-trivial ways to recover subtle, hidden or unexpected information. Practical examples... Read more
Articles
Early detection of Acute Chest Syndrome through electronic recording and analysis of auscultatory percussion
Acute chest syndrome (ACS) is the leading cause of death among people with sickle cell disease. ACS is clinically defined and diagnosed by the presence of a new pulmonary infiltrate on chest imaging with accompanying fever and respiratory symptoms like... Read more
Articles
LoCoMo-Net: A Low-Complex Deep Learning Framework for sEMG Based Hand Movement Recognition for Prosthetic Control
Background: The enhancement in the performance of the myoelectric pattern recognition techniques based on deep learning algorithm possess computationally expensive and exhibit extensive memory behavior. Therefore, in this paper we report a deep learning framework named ‘Low-Complex Movement recognition-Net’ (LoCoMo-Net)... Read more
Articles
Evaluation of the Vibe actigraph in patients with chronic obstructive pulmonary disease: A pilot study
Study objective: To validate the Vibe actigraph in assessing sleep-wake patterns compared to polysomnography (PSG) in patients with COPD. Methods: Nine stable COPD patients wore actigraphs while undergoing PSG. The correlation between total sleep time (TST), total sleep period (TSP),... Read more
Articles
Effect of laryngeal mask airway insertion on parameters derived from catacrotic phase of photoplethysmography under different concentrations of remifentanil
Background: Some parameters have been extracted from photoplethysmography (PPG) with a good relativity with nociception, but without encouraging results in qualifying the balance of nociception-anti-nociception (NAN). The features of PPG have not been thoroughly depicted and more prospective univariate parameters... Read more
Articles
Implications of Physiology-Sensitive Gait Exercise on the Lower Limb Electromyographic Activity of Hemiplegic Post-Stroke Patients: A Feasibility Study in Low Resource Settings
Background: Stroke is one of the leading causes of disability with ~80% of post-stroke survivors suffering from gait-related deficits. Conventional gait rehabilitation settings are labor-intensive and need rigorous involvement of clinicians (who use their expertise to decide the dosage of... Read more
Articles
Performance Evaluation of Mixed Reality Display for Guidance During Transcatheter Cardiac Mapping and Ablation
Cardiac electrophysiology procedures present the physician with a wealth of 3D information, typically presented on fixed 2D monitors. New developments in wearable mixed reality displays offer the potential to simplify and enhance 3D visualization while providing hands-free, dynamic control of... Read more
Articles
Adaptive Maximal Blood Flow Velocity Estimation From Transcranial Doppler Echos
Objective: Novel applications of transcranial Doppler (TCD) ultrasonography, such as the assessment of cerebral vessel narrowing/occlusion or the non-invasive estimation of intracranial pressure (ICP), require high-quality maximal flow velocity waveforms. However, due to the low signal-to-noise ratio of TCD spectrograms,... Read more
Published Articles
A Singular Spectrum Analysis-Based Data-Driven Technique for the Removal of Cardiogenic Oscillations in Esophageal Pressure Signals
Objective: Assessing the respiratory and lung mechanics of the patients in intensive care units is of utmost need in order to guide the management of ventilation support. The esophageal pressure (Peso) signal is a minimally invasive measure, which portrays the... Read more
Articles
Wearable Device-Independent Next Day Activity and Next Night Sleep Prediction for Rehabilitation Populations
Wearable sensor-based devices are increasingly applied in free-living and clinical settings to collect fine-grained, objective data about activity and sleep behavior. The manufacturers of these devices provide proprietary software that labels the sensor data at specified time intervals with activity... Read more
Published Articles
Ultrasound-Based Attenuation Imaging for the Non-Invasive Quantification of Liver Fat – A Pilot Study on Feasibility and Inter-Observer Variability
Attenuation imaging is a novel, ultrasound-based technique to objectively detect and quantify liver steatosis. In this study, we evaluated the performance and inter-observer variability of attenuation imaging and compared it to a known quantification method of liver fat, the hepatorenal... Read more
Published Articles
Teleoperation of Collaborative Robot for Remote Dementia Care in Home Environments
As a senile chronic, progressive and currently incurable disease, dementia has an enormous impact on society and life quality of the elderly. The development of teleoperation technology has changed the traditional way of care delivery and brought a variety of... Read more
Published Articles
Development of a Patch-type Flexible Oxygen Partial Pressure Sensor
Oxygen concentration in living organisms is one of the important vital indicators in emergency care and bedside medical settings. However, the oximetry method has limitations: the measurement site is limited to the tissue containing blood and the absolute value of... Read more
Published Articles
Total iron measurement in human serum with a novel smartphone-based assay
Abnormally low or high blood iron levels are common health conditions worldwide and can seriously affect an individual’s overall well-being. A low-cost point-of-care technology that measures blood iron markers with a goal of both preventing and treating iron-related disorders represents... Read more
Published Articles
Rapid, low-cost dielectrophoretic diagnosis of bladder cancer in a clinical setting
Bladder cancer is the 9th most common cancer worldwide. Diagnosing bladder cancer typically involves highly invasive cystoscopy, with followup monitored using uteroscopy. Molecular methods have been developed as an adjunct to this, but tend to be expensive or require expert... Read more
Published Articles
BioMeT and Algorithm Challenges: A Proposed Digital Standardized Evaluation Framework
Technology is advancing at an extraordinary rate. Continuous flows of novel data are being generated with the potential to revolutionize how we better identify, treat, manage, and prevent disease across therapeutic areas. However, lack of security of confidence in digital... Read more
Published Articles
DFENet: Deep Feature Enhancement Network for Accurate Calculation of Instantaneous Wave-Free Ratio
Accurate iFR calculation can provide important clinical information for intracoronary functional assessment without administration of adenosine, which needs to locate object points in the pressure waveforms: peak, the dichrotic notch and the pressure nadir at the end of diastole. We... Read more
Published Articles
Unified Open Hardware Platform for Digital X-Ray Devices; its Conceptual Model and First Implementation
Digital radiography devices are still the gold standard for diagnosis or therapy guidance in medicine. Despite the similarities between all direct digital x-ray systems, researchers and new companies face significant challenges during the development phase of innovative x-ray devices; each... Read more
Published Articles
Convex Representations Using Deep Archetypal Analysis for Predicting Glaucoma
The purpose of this study was to identify clinically relevant patterns of glaucomatous vision loss through convex representation to predict glaucoma several years prior to disease onset. Methods: We developed a deep archetypal analysis to identify patterns of glaucomatous vision... Read more
Published Articles
Accurate Fiducial Point Detection Using Haar Wavelet for Beat-by-Beat Blood Pressure Estimation
Pulse Arrival Time (PAT) derived from Electrocardiogram (ECG) and Photoplethysmogram (PPG) for cuff-less Blood Pressure (BP) measurement has been a contemporary and widely accepted technique. However, the features extracted for it are conventionally from an isolated pulse of ECG and... Read more
Articles, Published Articles
A 12-Lead ECG-Based System With Physiological Parameters and Machine Learning to Identify Right Ventricular Hypertrophy in Young Adults
The presence of right ventricular hypertrophy (RVH) accounts for approximately 5-10% in young adults. The sensitivity estimated by commonly used 12-lead electrocardiographic (ECG) criteria for identifying the presence of RVH is under 20% in the general population. The aim of... Read more
Articles, Published Articles
Determination of clinical parameters sensitive to functional voice disorders applying boosted decision stumps
Various voice assessment tools, such as questionnaires and aerodynamic voice characteristics, can be used to assess vocal function of individuals. However, not much is known about the best combinations of these parameters in identification of functional dysphonia in clinical settings.... Read more
Published Articles
Intubation Containment System for Improved Protection From Aerosolized Particles During Airway Management
Worldwide efforts to protect front line providers performing endotracheal intubation during the COVID-19 pandemic have led to innovative devices. Authors evaluated the aerosol containment effectiveness of a novel intubation aerosol containment system (IACS) compared with a recently promoted intubation box... Read more
Published Articles
Integrated Development Environment for EEG-Driven Cognitive-Neuropsychological Research
EEG-driven research is paramount in cognitive-neuropsychological studies, as it provides a non-invasive window to the underlying neural mechanisms of cognition and behavior. A myriad collection of software and hardware frameworks has been developed to alleviate some of the technical barriers... Read more
Articles, Published Articles
A Data-Driven Simulator for the Strategic Positioning of Aerial Ambulance Drones Reaching Out-Of-Hospital Cardiac Arrests: A Genetic Algorithmic Approach
The Internet of Things provide solutions for many societal challenges including the use of unmanned aerial vehicles to assist in emergency situations that are out of immediate reach for traditional emergency services. Out of hospital cardiac arrest (OHCA) can result... Read more
Articles, Published Articles
An Electrocardiographic System with Anthropometrics via Machine Learning to Screen Left Ventricular Hypertrophy among Young Adults
The prevalence of physiological and pathological left ventricular hypertrophy (LVH) among young adults is about 5%. A use of electrocardiographic (ECG) voltage criteria and machine learning for the ECG parameters to identify the presence of LVH is estimated only 20-30%... Read more
Articles, Published Articles
3D Motion Estimation of Left Ventricular Dynamics Using MRI and Track-to-Track Fusion
This study investigates the estimation of three dimensional (3D) left ventricular (LV) motion using the fusion of different two dimensional (2D) cine magnetic resonance (CMR) sequences acquired during routine imaging sessions. Although standard clinical cine CMR data is inherently 2D,... Read more
Articles, Published Articles
Multi-Source Transfer Learning via Ensemble Approach for Initial Diagnosis of Alzheimer’s Disease
Alzheimer’s disease (AD) is one of the most common progressive neurodegenerative diseases, and the number of AD patients has increased year after year with the global aging trend. The onset of AD has a long preclinical stage. If doctors can... Read more
Articles, Published Articles
Real-time Lung Tumor Tracking Using A CUDA Enabled Nonrigid Registration Algorithm for MRI
This study intends to develop an accurate, real-time tumor tracking algorithm for the automated radiation therapy for cancer treatment using Graphics Processing Unit (GPU) computing. Although a previous moving mesh based tumor tracking approach has been shown to be successful... Read more
Articles, Published Articles
Vibrotactile-feedback Device for Postural Balance among Malocclusion Patients
Multiple studies have suggested that some associations exist between occlusal factors and postural alterations. Objectives: This study aimed to evaluate the effectiveness of a vibrotactile posture trainer device, comprised a wearable device containing an accelerometer sensor to measure the angle... Read more
Articles, Published Articles
Monitoring Wound Healing with Contactless Measurements and Augmented Reality
This work presents a device for non-invasive wound parameters assessment, designed to overcome the drawbacks of traditional methods, which are mostly rough, inaccurate, and painful for the patient. The device estimates the morphological parameters of the wound and provides augmented... Read more
Articles, Published Articles
A Composite Fabric-Based Soft Rehabilitation Glove With Soft Joint for Dementia in Parkinson’s Disease
A kind of wearable exoskeleton soft rehabilitation glove is proposed for the dementia in Parkinson’s disease (PD) patients with loss of hand function, limited range of motion, and insufficient finger muscle strength to carry out rehabilitation exercise training in a... Read more
Articles, Published Articles
Preliminary Comparison of Zero-Gravity Chair with Tilt Table in Relation to Heart Rate Variability Measurements
Heart rate variability (HRV) measurements are performed using a tilt-table (TT) to diagnose dysfunctionality in the autonomic nervous system (ANS) and the cardiovascular system. To maintain homeostasis, the ANS adapts to body position changes through alterations in sympathetic and parasympathetic... Read more
Articles, Published Articles
A Wearable System For Attenuating Essential Tremor Based On Peripheral Nerve Stimulation
Currently available treatments for kinetic tremor can cause intolerable side effects or be highly invasive and expensive. Even though several studies have shown the positive effects of external feedback (i.e., electrical stimulation) for suppressing tremor, such approaches have not been... Read more
Articles, Published Articles
The identification of Alzheimer’s disease using functional connectivity between activity voxels in resting-state fMRI data
Alzheimer’s disease (AD) is a common neurodegenerative disease occurring in the elderly population. The effective and accurate classification of AD symptoms by using functional magnetic resonance imaging (fMRI) has a great significance for the clinical diagnosis and prediction of AD... Read more
Articles, Published Articles
Development Of Low-Cost Point-Of-Care Technologies For Cervical Cancer Prevention Based On A Single-Board Computer
Cervical cancer disproportionally affects women in low- and middle-income countries, in part due to the difficulty of implementing existing cervical cancer screening and diagnostic technologies in low-resource settings. Single-board computers offer a low-cost alternative to provide computational support for automated... Read more
Articles, Published Articles
MyoNet: A Transfer-learning based LRCN for Lower Limb Movement Recognition and Knee Joint Angle Prediction for Remote Monitoring of Rehabilitation Progress from sEMG
The clinical assessment technology such as remote monitoring of rehabilitation progress for lower limb related ailments rely on the automatic evaluation of movement performed along with an estimation of joint angle information. In this paper, we introduce a transfer-learning based... Read more
Articles, Published Articles
Feasibility of using high-contrast grating as a point-of-care sensor for therapeutic drug monitoring of immunosuppressants
Abstract Point-of-care (POC) testing has demonstrated great transformative potential in personalized medicine. In particular, patients undergoing transplantation require POC testing to ensure appropriate serum immunosuppressant levels so as to maintain adequate graft function and survival. However, no suitable POC device... Read more
Articles, Published Articles
Automated Detection of Symptomatic Autonomic Dysreflexia through Multimodal Sensing
Objective: Autonomic Dysreflexia (AD) is a potentially life-threatening syndrome which occurs in individuals with higher level spinal cord injuries (SCI). AD is caused by triggers which can lead to rapid escalation of pathophysiological responses and if the trigger is not... Read more
Articles, Published Articles
Accuracy of the Apple Watch 4 to Measure Heart Rate in Patients with Atrial Fibrillation
Wearable wrist-monitors offer an unobtrusive way to acquire heart rate data in an efficient manner. Previous work in this field has focused on studying healthy subjects during exercise but has yet to assess the efficacy of these devices in patients... Read more
Articles, Published Articles
Intraoperative Localization of STN during DBS Surgery using a Data-driven Model
A new approach is presented for localizing the Subthalamic Nucleus (STN) during Deep Brain Stimulation (DBS) surgery based on microelectrode recordings (MERs). DBS is an accepted treatment for individuals living with Parkinson’s Disease (PD). This surgery involves implantation of a... Read more
Articles, Published Articles
Multiple Linear Discriminant Models for Extracting Salient Characteristic Patterns in Capsule Endoscopy Images for Multi-Disease Detection
Background: Computer-aided disease detection schemes from wireless capsule endoscopy (WCE) videos have received great attention by the researchers for reducing physicians’ burden due to the time-consuming and risky manual review process. While single disease classification schemes are greatly dealt by... Read more
Articles, Published Articles
A Multi-Task Group Bi-LSTM Networks Application on Electrocardiogram Classification
Background: Cardiovascular diseases (CVD) are the leading cause of death globally. Electrocardiogram (ECG) analysis can provide thoroughly assessment for different CVDs efficiently. We propose a multi-task group bidirectional long short-term memory (MTGBi-LSTM) framework to intelligent recognize multiple CVDs based on... Read more
Articles, Published Articles
Towards an Effective Patient Health Engagement System Using Cloud-Based Text Messaging Technology
    Early Access Note: Early Access articles are new content made available in advance of the final electronic or print versions and result from IEEE’s Preprint or Rapid Post processes. Preprint articles are peer-reviewed but not fully edited. Rapid Post articles are... Read more
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An Automated Framework for Large scale Retrospective Analysis of Ultrasound Images
      Early Access Note: Early Access articles are new content made available in advance of the final electronic or print versions and result from IEEE’s Preprint or Rapid Post processes. Preprint articles are peer-reviewed but not fully edited. Rapid Post articles are... Read more
Articles, Published Articles
Predictive Monitoring of Critical Cardiorespiratory Alarms in Neonates under Intensive Care
      Early Access Note: Early Access articles are new content made available in advance of the final electronic or print versions and result from IEEE’s Preprint or Rapid Post processes. Preprint articles are peer-reviewed but not fully edited. Rapid Post articles are... Read more
Articles, Published Articles
Cloud-Based Automated Clinical Decision Support System for Detection and Diagnosis of Lung Cancer in Chest CT
         Early Access Note: Early Access articles are new content made available in advance of the final electronic or print versions and result from IEEE’s Preprint or Rapid Post processes. Preprint articles are peer-reviewed but not fully edited. Rapid Post articles are... Read more
Articles, Published Articles
Subsequent Use of a Pressure Sensor to Record Intra-abdominal Pressure after Maximum Vaginal Closure Force in a Clinical Trial
      Early Access Note: Early Access articles are new content made available in advance of the final electronic or print versions and result from IEEE’s Preprint or Rapid Post processes. Preprint articles are peer-reviewed but not fully edited. Rapid Post articles are... Read more
Articles, Published Articles
High Precision Digitization of Paper-Based ECG Records: A Step Toward Machine Learning
      Early Access Note: Early Access articles are new content made available in advance of the final electronic or print versions and result from IEEE’s Preprint or Rapid Post processes. Preprint articles are peer-reviewed but not fully edited. Rapid Post articles are... Read more
Articles, Published Articles
Small Scale Perception in Medical Body Area Networks
      Early Access Note: Early Access articles are new content made available in advance of the final electronic or print versions and result from IEEE’s Preprint or Rapid Post processes. Preprint articles are peer-reviewed but not fully edited. Rapid Post articles are... Read more
Articles, Published Articles
Recognizing Hemiparetic Ankle Deficits Using Wearable Pressure Sensors
   Objective: To provide proof-of-concept for a novel method to recognize impaired push-off and foot-drop deficits in hemiparetic gait using analog pressure sensors. These data may enhance feedback from a modular ankle exoskeleton (such as Anklebot) for stroke rehabilitation, which now... Read more
Articles, Published Articles
Development of an Implantable Wireless and Batteryless Bladder Pressure Monitor System for Lower Urinary Tract Dysfunction
        Early Access Note: Early Access articles are new content made available in advance of the final electronic or print versions and result from IEEE’s Preprint or Rapid Post processes. Preprint articles are peer-reviewed but not fully edited. Rapid Post articles are... Read more
Articles, Published Articles
Vision-Based Heart and Respiratory Rate Monitoring During Sleep — A Validation Study for the Population at Risk of Sleep Apnea
Early Access Note: Early Access articles are new content made available in advance of the final electronic or print versions and result from IEEE’s Preprint or Rapid Post processes. Preprint articles are peer-reviewed but not fully edited. Rapid Post articles are... Read more
Articles, Published Articles
Fluorescence Imaging of Mitochondrial Redox State to Assess Diabetic Wounds
       Early Access Note: Early Access articles are new content made available in advance of the final electronic or print versions and result from IEEE’s Preprint or Rapid Post processes. Preprint articles are peer-reviewed but not fully edited. Rapid Post articles are... Read more
Articles, Published Articles
Whole Stomach 3D Reconstruction and Frame Localization from Monocular Endoscope Video
      Gastric endoscopy is a common clinical practice that enables medical doctors to diagnose various lesions inside a stomach. In order to identify the location of a gastric lesion such as early cancer and a peptic ulcer within the stomach, this... Read more
Articles, Published Articles
A Practical Electronic Health Record-based Dry Weight Supervision Model for Hemodialysis Patients
       Objective : Dry Weight (DW) is a typical hemodialysis (HD) prescription for End-Stage Renal Disease (ESRD) patients. However, an accurate DW assessment is difficult due to the complication of body components and individual variations. Our objective is to model a... Read more
Articles, Published Articles
A Pilot Study of Facial Nerve Stimulation on Cerebral Artery Vasospasm in Subarachnoid Hemorrhage Patients
        Background: The objective of this pilot study was to assess the safety and efficacy of VitalFlow stimulation in aneurysmal subarachnoid hemorrhage (aSAH) patients with vasospasm for the purpose of guiding the design of larger, controlled studies in vasospasm patients, a... Read more
Articles, Published Articles
Robust Sparse Representation and Multiclass Support Matrix Machines for the Classification of Motor Imagery EEG Signals
   Early Access Note: Early Access articles are new content made available in advance of the final electronic or print versions and result from IEEE’s Preprint or Rapid Post processes. Preprint articles are peer-reviewed but not fully edited. Rapid Post articles are... Read more
Articles, Published Articles
Automated Detection of Parkinson’s Disease Based on Multiple Types of Sustained Phonations using Linear Discriminant Analysis and Genetically Optimized Neural Network
    Early Access Note: Early Access articles are new content made available in advance of the final electronic or print versions and result from IEEE’s Preprint or Rapid Post processes. Preprint articles are peer-reviewed but not fully edited. Rapid Post articles are... Read more
Articles, Published Articles
Near Real-Time Implementation of An Adaptive Seismocardiography — ECG Multimodal Framework for Cardiac Gating
   Early Access Note: Early Access articles are new content made available in advance of the final electronic or print versions and result from IEEE’s Preprint or Rapid Post processes. Preprint articles are peer-reviewed but not fully edited. Rapid Post articles are... Read more
Articles, Published Articles
Non-Invasive Imaging of Normalized Solid Stress in Cancers in vivo
   Early Access Note: Early Access articles are new content made available in advance of the final electronic or print versions and result from IEEE’s Preprint or Rapid Post processes. Preprint articles are peer-reviewed but not fully edited. Rapid Post articles are... Read more
Articles, Published Articles
Machine Learning Approach for Prediction of Hematic Parameters in Hemodialysis Patients
       Early Access Note: Early Access articles are new content made available in advance of the final electronic or print versions and result from IEEE’s Preprint or Rapid Post processes. Preprint articles are peer-reviewed but not fully edited. Rapid Post articles are... Read more
Articles, Published Articles
Feasibility of Early Meal Detection Based on Abdominal Sound
     Early Access Note: Early Access articles are new content made available in advance of the final electronic or print versions and result from IEEE’s Preprint or Rapid Post processes. Preprint articles are peer-reviewed but not fully edited. Rapid Post articles are... Read more
Articles, Published Articles
Smart Lighting Clinical Testbed Pilot Study on Circadian Phase Advancement
         Objective: Lighting is a strong synchronizer for circadian rhythms, which in turn drives a wide range of biological functions. The objective of our work is a) to construct a clinical in-patient testbed with smartİ lighting, and b) evaluate its feasibility... Read more
Articles, Published Articles
A Miniature Dual-biomarker-based Sensing and Conditioning Device for Closed-loop DBS
  In this paper, a dual-biomarker-based neural sensing and conditioning device is proposed for closing the feedback loop in deep brain stimulation devices. The device explores both local field potentials (LFPs) and action potentials (APs) as measured biomarkers. It includes two... Read more
Articles, Published Articles
A Mobile Application for Keyword Search in Real-World Scenes
     Keyword search in a cluttered environment is difficult in general, and even more challenging for people with low vision. While magnification can help in reading for low vision people, it does not facilitate efficient visual search due to the constriction... Read more
Articles, Published Articles
Sex-related Differences in Photoplethysmography Signals Measured from Finger and Toe
  Sex plays an important role in the normal cardiovascular system function including resting heart rate and arterial blood pressure. In addition, it has been reported that men and women are at different levels of risk for cardiovascular diseases. The aim... Read more
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Elastographic Tomosynthesis from X-ray Strain Imaging of Breast Cancer
Noncancerous breast tissue and cancerous breast tissue have different elastic properties. In particular, cancerous breast tumors are stiff when compared to the noncancerous surrounding tissue. This difference in elasticity can be used as a means for detection through the method... Read more
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Locally Linear Embedding and fMRI feature selection in psychiatric classification
Background: Functional magnetic resonance imaging (fMRI) provides non-invasive measures of neuronal activity using an endogenous Blood Oxygenation-Level Dependent (BOLD) contrast. This article introduces a nonlinear dimensionality reduction (Locally Linear Embedding) to extract informative measures of the underlying neuronal activity from... Read more
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Classification of Scalp EEG States Prior to Clinical Seizure Onset
     Objective: To investigate the feasibility of improving the performance of an EEG-based multistate classifier (MSC) previously proposed by our group. Results: Using the random forest (RF) classifiers on the previously reported dataset of patients, but with three improvements to classification... Read more
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Feature Extraction Based Machine Learning for Human Burn Diagnosis From Burn Images
    Burn is one of the serious public health problems. Usually, burn diagnoses are based on expert medical and clinical experience and it is necessary to have a medical or clinical expert to conduct an examination in restorative clinics or at... Read more
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Defining the Relationship Between Compressive Stress and Tissue Trauma During Laparoscopic Surgery Using Human Large Intestine
      Excessive magnitudes of compressive stress exerted on gastrointestinal tissues can lead to pathological scar tissue or adhesion formation, bleeding, inflammation or even death from bowel perforation and sepsis. It is currently unknown however, at exactly what magnitude of compressive stress... Read more
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Prediction of Recovery from Severe Hemorrhagic Shock Using Logistic Regression
   Abstract Objective: This study implements logistic regression models (LRMs) and feature selection for creating a predictive model for recovery form hemorrhagic shock (HS) with resuscitation using blood in multiple experimental rat animal protocols Methods: A total of 61 animals were studied... Read more
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Non-contact Early Warning of Shaking Palsy
        Abstract Objective: Parkinsonian gait is a defining feature of Shaking Palsy (SP) and it has one of the worse impact on human healthy life than other SP symptoms. The objective of this work is to propose a Parkinsonian gait detection system... Read more
Articles, Published Articles
Reduced Rank Least Squares for Real-Time Short Term Estimation of Mean Arterial Blood Pressure in Septic Patients Receiving Norepinephrine
    Abstract Norepinephrine (NE), an endogenous catecholamine, is a mainstay treatment for septic shock, which is a life-threatening manifestation of severe infection. NE counteracts the loss in blood pressure associated with septic shock. However, an NE infusion that is too low fails... Read more
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The Conceptual Design of a Novel Workstation for Seizure Prediction using Machine Learning with Potential eHealth Applications
   Abstract Recent attempts to predict refractory epileptic seizures using machine learning algorithms to process electroencephalograms (EEGs) have shown great promise. However, research in this area requires a specialized workstation. Commercial solutions are unsustainably expensive, can be unavailable in most countries, and... Read more
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Automated Vision-Based High Intraocular Pressure Detection Using Frontal Eye Images
   Abstract INTRODUCTION: Glaucoma, the silent thief of vision, is mostly caused by the gradual increase of pressure in the eye which is known as Intraocular Pressure (IOP). An effective way to prevent the rise in eye pressure is by early detection.... Read more
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Context Dependent Fuzzy Associated Statistical Model for Intensity Inhomogeneity Correction from Magnetic Resonance Images
    Abstract: In this paper, a novel context-dependent fuzzy set associated statistical model-based intensity inhomogeneity correction technique for magnetic resonance image (MRI) is proposed. The observed MRI is considered to be affected by intensity inhomogeneity and it is assumed to be a... Read more
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Deep Learning Based Proarrhythmia Analysis Using Field Potentials Recorded from Human Pluripotent Stem Cells Derived Cardiomyocytes
       Abstract: An early characterization of drug-induced cardiotoxicity may be possible by combining comprehensive in vitro proarrhythmia assay and deep learning techniques. We aimed to develop a method to automatically detect irregular beating rhythm of field potentials recorded from human pluripotent stem... Read more
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Evaluation of Formalin Fixation for Tissue Biopsies Using Shear Wave Laser Speckle Imaging System
   Abstract: Chemical fixation is the slowest and often the most uncontrolled step in the multi-step process of preparing tissue for histopathology. In order to reduce the time from taking a core needle biopsy to making a diagnosis, a new approach is... Read more
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Fracture Healing Monitoring by Impact Tests: Single Case Study of a Fractured Tibia with External Fixator
   Abstract: The correct evaluation of the healing process is important to define proper times of fixator dynamization and removal, avoiding refractures. Unfortunately, a quantitative healing assessment is not yet available in clinical practice. The aim of the paper is to prove... Read more
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Effect of a Soft Robotic Sock Device on Lower Extremity Rehabilitation following Stroke: A Preliminary Clinical Study with Focus on Deep Vein Thrombosis Prevention
    Abstract: Background and objective: Immobility of the lower extremity due to medical conditions such as stroke can lead to medical complications such as deep vein thrombosis or ankle contracture, and thereafter prolonged recovery process of the patients. In this preliminary clinical... Read more
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Nature-Inspired Multiobjective Cancer Subtype Diagnosis
     Abstract Cancer gene expression data is of great importance in cancer subtype diagnosis and drug discovery. Many computational methods have been proposed to classify subtypes using those data. However, most of the previous computational methods suffer from poor interpretability, experimental noises,... Read more
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Cardiac-DeepIED: Automatic Pixel-level Deep Segmentation for Cardiac Bi-ventricle Using Improved End-to-End Encoder-Decoder Network
     Abstract Accurate segmentation of cardiac bi-ventricle (CBV) from magnetic resonance (MR) images has a great significance to analyze and evaluate the function of the cardiovascular system. However, the complex structure of CBV image makes fully automatic segmentation as a well-known challenge.... Read more
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Implementation and Long-Term Evaluation of a Hearing Aid Supported Tinnitus Treatment using Notched Environmental Sounds
       Abstract Recent work has shown that sharp spectral edges in acoustic stimuli might have advantageous effects in the treatment of tonal tinnitus. In the course of this paper, we evaluate the long-term effects of spectrally notched hearing aids on the subjective... Read more
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Transcranial Impedance Changes during Sleep: a Rheoencephalography Study
      Abstract Objective: To demonstrate the utility of rheoencephalography (REG) for measuring cerebral blood flow and fluid dynamics during different stages of sleep. Methods: Anteroposterior cranial electrical impedance was measured with concurrent polysomnography in a group of healthy subjects during sleep. Transcranial... Read more
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Use of Accelerometry for Long Term Monitoring of Stroke Patients
      Abstract Stroke patients are monitored hourly by physicians and nurses in an attempt to better understand their physical state. To quantify the patients’ level of mobility, hourly movement (i.e. motor) assessment scores are performed, which can be taxing and time-consuming for... Read more
Articles, Published Articles
Identification of Developmental Delay in Infants using Wearable Sensors: Full-Day Leg Movement Statistical Feature Analysis
       Abstract This paper examines how features extracted from full-day data recorded by wearable sensors are able to differentiate between infants with typical development and those with or at risk for developmental delays. Wearable sensors were used to collect full-day (8–13 h)... Read more
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Pre-Clinical Translation of Second Harmonic Microscopy of Meniscal and Articular Cartilage Using a Prototype Nonlinear Microendoscope
      Abstract Previous studies using nonlinear microscopy have demonstrated that osteoarthritis (OA) is characterized by the gradual replacement of Type II collagen with Type I collagen. The objective of this study was to develop a prototype nonlinear laser scanning microendoscope capable of... Read more
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EMG Pattern Recognition Control of the DEKA Arm: Impact on User Ratings of Satisfaction and Usability
     Abstract The DEKA Arm has multiple degrees of freedom which historically have been operated primarily by inertial measurement units (IMUs). However, the IMUs are not appropriate for all potential users; new control methods are needed. The purposes of this study were:... Read more
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High Resolution Cervical Auscultation Signal Features Reflect Vertical and Horizontal Displacement of the Hyoid Bone During Swallowing
        Abstract Millions of people across the globe suffer from swallowing difficulties, known as dysphagia, which can lead to malnutrition, pneumonia, and even death. Swallowing cervical auscultation, which has been suggested as a noninvasive screening method for dysphagia, has not been associated... Read more
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Laryngeal Pressure Estimation with a Recurrent Neural Network
    Abstract Quantifying the physical parameters of voice production is essential for understanding the process of phonation and can aid in voice research and diagnosis. As an alternative to invasive measurements, they can be estimated by formulating an inverse problem using a... Read more
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Improving Detection of Rapid Cystic Fibrosis Disease Progression—Early Translation of a Predictive Algorithm into a Point-of-Care Tool
      Abstract The clinical course of cystic fibrosis (CF) lung disease is marked by acute drops of lung function, defined clinically as rapid decline. As such, lung function is monitored routinely through pulmonary function testing, producing hundreds of measurements over the lifespan... Read more
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Patient Centered Communication and e-health information exchange patterns: Findings from a National Cross-Sectional Survey
Abstract This paper aimed to determine whether there was a connection between patient’s perception of communication with their doctors in the visit and their use of online health information exchange using a nationally representative survey. We used the data from the... Read more
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An Initial Investigation of Unmanned Aircraft Systems (UAS) and Real-Time Organ Status Measurement for Transporting Human Organs
      Organ transportation has yet to be substantially innovated. If organs could be moved by drone, instead of ill-timed commercial aircraft or expensive charter flights, lifesaving organs could be transplanted more quickly. A modified, six-rotor UAS was used to model situations... Read more
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Intuitive Clinician Control Interface for a Powered Knee-Ankle Prosthesis: A Case Study
      This paper presents a potential solution to the challenge of configuring powered knee-ankle prostheses in a clinical setting. Typically, powered prostheses use impedance-based control schemes that contain several independent controllers which correspond to consecutive periods along the gait cycle. This... Read more
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An Open-Source Feature Extraction Tool for the Analysis of Peripheral Physiological Data
      Electrocardiogram, electrodermal activity, electromyogram, continuous blood pressure, and impedance cardiography are among the most commonly used peripheral physiological signals (biosignals) in psychological studies and healthcare applications, including health tracking, sleep quality assessment, disease early-detection/diagnosis, and understanding human emotional and affective... Read more
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Sleep Apnea Syndrome Sensing at C-Band
         A non-intrusive sleep apnea detection system using a C-Band channel sensing technique is proposed to monitor sleep apnea syndrome in real time. The system utilizes perturbations of RF signals to differentiate between patient’s breathing under normal and sleep apnea conditions.... Read more
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An AI-based Heart Failure Treatment Adviser System
        Management of heart failure is a major health care challenge. Healthcare providers are expected to use best practices described in clinical practice guidelines, which typically consist of a long series of complex rules. For heart failure management, the relevant guidelines... Read more
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Virtual Neonatal Echocardiographic Training System (VNETS): An Echocardiographic Simulator for Training Basic Transthoracic Echocardiography Skills in Neonates and Infants
      There is a great need for training in pediatric echocardiography. In addition to physicians being trained in pediatric cardiology and echocardiography technologists, neonatologist, pediatric intensivists, and other health care professionals may be interested in such training. Since, there is limited... Read more
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Reaction Time Predicts Brain-Computer Interface Aptitude
     There is evidence that 15–30% of the general population cannot effectively operate brain–computer interfaces (BCIs). Thus the BCI performance predictors are critically required to pre-screen participants. Current neurophysiological and psychological tests either require complicated equipment or suffer from subjectivity. Thus,... Read more
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Improving Detection of Rapid Cystic Fibrosis Disease Progression—Early Translation of a Predictive Algorithm into a Point-of-Care Tool
      Early Access Note: Early Access articles are new content made available in advance of the final electronic or print versions and result from IEEE’s Preprint or Rapid Post processes. Preprint articles are peer-reviewed but not fully edited. Rapid Post articles are... Read more
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Closed Loop Intravenous Drug Administration Using Photoplethysmography
     An optically-based injection control system has been developed for preclinical use for an intravenous drug delivery application. Current clinical drug delivery for oncology typically provides for intravenous administration without an awareness of achieved plasma concentration, yet interpatient variability produces consequences... Read more
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Patient-Specific Pose Estimation in Clinical Environments
              Abstract Reliable posture labels in hospital environments can augment research studies on neural correlates to natural behaviors and clinical applications that monitor patient activity. However, many existing pose estimation frameworks are not calibrated for these unpredictable settings. In this paper, we... Read more
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A Ballistographic Approach for Continuous and Non-Obtrusive Monitoring of Movement in Neonates
       Continuously monitoring body movement in preterm infants can have important clinical applications since changes in movement-patterns can be a significant marker for clinical deteriorations including the onset of sepsis, seizures, and apneas. This paper proposes a system and method to... Read more
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Kinect-Based In-Home Exercise System for Lymphatic Health and Lymphedema intervention
    Using Kinect sensors to monitor and provide feedback to patients performing intervention or rehabilitation exercises is an upcoming trend in healthcare. However, the joint positions measured by the Kinect sensor are often unreliable, especially for joints that are occluded by... Read more
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Classification of Alzheimer’s Disease, Mild Cognitive Impairment and Normal Control Subjects Using Resting-State fMRI Based Network Connectivity Analysis
     This paper proposes a robust method for the Alzheimer’s disease (AD), mild cognitive impairment (MCI), and normal control subject classification under size limited fMRI data samples by exploiting the brain network connectivity pattern analysis. First, we select the regions of... Read more
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Stroke Patients’ Acceptance of a Smart Garment for Supporting Upper Extremity Rehabilitation
        The objective is to evaluate to which extent that Zishi a garment equipped with sensors that can support posture monitoring can be used in upper extremity rehabilitation training of stroke patients. Seventeen stroke survivors (mean age: 55 years old, SD... Read more
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Robust and Accurate Capture of Human Joint Pose Using an Inertial Sensor
     Wearable inertial measurement units (IMU) measuring acceleration, earth magnetic field, and gyroscopic measurements can be considered for capturing human skeletal postures in real time. Number of movement disorders require accurate and robust estimation of the human joint pose. Though these... Read more
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An Adaptive Seismocardiography (SCG)-ECG Multimodal Framework for Cardiac Gating Using Artificial Neural Networks
To more accurately trigger data acquisition and reduce radiation exposure of coronary computed tomography angiography (CCTA), a multimodal framework utilizing both electrocardiography (ECG) and seismocardiography (SCG) for CCTA prospective gating is presented. Relying upon a three-layer artificial neural network that... Read more
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Passive Self Resonant Skin Patch Sensor to Monitor Intraventricular Volume using Electromagnetic Properties of Fluid Volume Changes
This paper focuses on the development of a passive, lightweight skin patch sensor that can measure fluid volume changes in the heart in a non-invasive, point-of-care setting. The wearable sensor is an electromagnetic, self-resonant sensor configured into a specific pattern... Read more
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Screening for Atrial Fibrillation during Automatic Blood Pressure Measurements
Atrial fibrillation (Afib) contributes significantly to overall cardiovascular risk. Widespread screening for Afib in primary care is sometimes performed by palpation, but suffers from low accuracy and is dependent on clinician experience. Algorithms implemented on oscillometric blood pressure devices can... Read more
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Unobtrusive Detection of Simulated Orthostatic Hypotension and Supine Hypertension using Ballistocardiogram and Electrocardiogram of Healthy Adults
Effective management of neurogenic orthostatic hypotension and supine hypertension (SH-OH) due autonomic failure requires a frequent and timely adjustment of medication throughout the day to maintain the blood pressure (BP) within the normal range, i.e., an accurate depiction of BP... Read more
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Integrating Brain Implants with Local and Distributed Computing Devices: A Next Generation Epilepsy Management System
                          Brain stimulation has emerged as an effective treatment for a wide range of neurological and psychiatric diseases. Parkinson’s disease, epilepsy, and essential tremor have FDA indications for electrical brain stimulation using intracranially implanted electrodes. Interfacing implantable brain devices with local... Read more
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Radial Pulse Spectrum Analysis as Risk Markers to Improve the Risk Stratification of Silent Myocardial Ischemia in Type 2 Diabetic Patients
      Diabetic patients with silent myocardial ischemia (SMI) have elevated rates of morbidity and mortality and need intensive care and monitoring. An early predictor of SMI may lead to early diagnosis and medical treatment to prevent progression and adverse clinical events.... Read more
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Healthcare Event and Activity Logging
   Part of the Special Issue on Advanced Internet of Things in Personalized Healthcare Systems: Validation, Analysis and Utilization The health of patients in the intensive care unit (ICU) can change frequently and inexplicably. Crucial events and activities responsible for these changes... Read more
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Accelerometer Based Assessment of Intestinal Peristalsis: Towards Miniaturized Low Power Solutions for Intestinal Implants
    Intestinal electrical stimulation via implants is already used to treat several disorders like constipation or incontinence. Stimulation parameters are most often empiric and not based on systematic studies. One prerequisite to evaluate effects of intestinal electrical stimulation is a direct... Read more
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Low-Power and Low-Cost Dedicated Bit-Serial Hardware Neural Network for Epileptic Seizure Prediction System
  This paper presents results of using a simple bit-serial architecture as a method of designing an extremely low-power and low-cost neural network processor for epilepsy seizure prediction. The proposed concept is based on a novel bit-serial data processing unit (DPU)... Read more
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Chest Compression Quality in a Newborn Manikin. A Randomized Crossover Trial
        Abstract The objective of this study was to examine changes in applied force and rate of chest compression (CC) during 5 min of CC with a target CC rate of 90/min (CC90) or 120/min (CC120) with and without metronome guidance during... Read more
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Design and Study of a Smart Cup for Monitoring the Arm and Hand Activity of Stroke Patients
  This paper presents a new platform to monitor the arm and hand activity of stroke patients during rehabilitation exercises in the hospital and at home during their daily living activities. The platform provides relevant data to the therapist in order... Read more
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Optimize Transfer Learning for Lung Diseases in Bronchoscopy Using a New Concept: Sequential Fine-Tuning
        Bronchoscopy inspection, as a follow-up procedure next to the radiological imaging, plays a key role in the diagnosis and treatment design for lung disease patients. When performing bronchoscopy, doctors have to make a decision immediately whether to perform a biopsy.... Read more
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An Ultra Low Power Smart Headband for Real-time Epileptic Seizure Detection
     Abstract In this paper, the design of a smart headband for epileptic seizure detection is presented. The proposed headband consists of four key components: 1) an analog front-end circuitry, 2) an epileptic seizure detection tag (ESDT), 3) a Bluetooth Low Power... Read more
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Design and Integration of an Inexpensive Wearable Mechanotactile Feedback System for Myoelectric Prostheses
     Abstract The aim of this study was to demonstrate the functionality of an inexpensive mechanotactile sensory feedback system for transhumeral myoelectric prostheses. We summarize the development of a tactile-integrated prosthesis including (i) evaluation of sensors that were retrofit onto existing commercial... Read more
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Improved Detection of Lung Fluid with Standardized Acoustic Stimulation of the Chest
     Accumulation of excess air and water in the lungs leads to breakdown of respiratory function and is a common cause of patient hospitalization. Compact and non-invasive methods to detect the changes in lung fluid accumulation can allow physicians to assess... Read more
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Image Quality Evaluation in Clinical Research: A Case Study on Brain and Cardiac MRI Images in Multi-Center Clinical Trials
    Abstract MRI system images are important components in the development of drugs because it can reveal the underlying pathology in diseases. Unfortunately the processes of image acquisition, storage, transmission, processing and analysis can influence image quality with the risk of compromising... Read more
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A Novel Antibacterial Membrane Electrode Based on Bacterial Cellulose/Polaniline/AgNO3 Composite for Bio-Potential Signal Monitoring
          Part of the NIH-IEEE POCT 2017 Special Issue Abstract: Objective: We propose a flexible, dry and antibacterial electrode with low and stable skin electrode contact impedance for bio-potential signal monitoring. Methods: We fabricated bacterial cellulose/polyaniline/AgNO3 nanocomposite membrane (BC/PANI/AgNO3) and used it for... Read more
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Precise Dispensing Technology Using Electroformed Tubes for Micro-Volume Blood Diagnosis
Part of the NIH-IEEE POCT 2017 Special Issue     Precise dispensing of droplets is a crucial step for acquiring reliable blood diagnostic results. When the source sample volume is limited, the need for precise dispensing of submicroliter and nanoliter quantities is especially... Read more
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A Handheld, Colorimetric Optoelectronic Dynamics Analyzer (CODA) for Measuring Total Ammonia of Biological Samples
       Abstract: This work introduces a wireless, solid-state, portable, and automated device capable of semi-continuously measuring the total ammonia (ammonia (NH3) and ammonium (NH4 + )) levels of fluids, including biological samples. This device reliably measures the total ammonia of biological samples... Read more
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Correlated Regression Feature Learning for Automated Right Ventricle Segmentation
      Abstract: Accurate segmentation of right ventricle (RV) from cardiac magnetic resonance (MR) images can help doctor to robustly quantify the clinical indices including ejection fraction. In this paper, we develop one regression convolutional neural network (RegressionCNN) that a holistic regression model... Read more
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Design of a Precision Medication Dispenser: preventing overdose by increasing accuracy and precision of dosage
       Liquid medication overdose in pediatric patients results in over 70000 visits to the emergency room yearly in the USA. Various studies have demonstrated that the root cause of this high incidence is due to user and device error in dose... Read more
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Reduction of Prolonged Excessive Pressure in Seated Persons with Paraplegia Using Wireless Lingual Tactile Feedback: A Randomized Controlled Trial
            Pressure ulcers (PU) are known to be a high-cost disease with a risk of severe morbidity. This paper evaluates a new clinical strategy based on an innovative medical device [Tongue Display Unit (TDU)] that implements perceptive supplementation in order to... Read more
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A Novel Cardiac Auscultation Monitoring System Based on Wireless Sensing for Healthcare
     Part of the Special Issue on Advanced Internet of Things in Personalized Healthcare Systems: Validation, Analysis and Utilization Heart sounds deliver vital physiological and pathological evidence about health. Wireless cardiac auscultation offers continuous cardiac monitoring of an individual without 24*7 manual... Read more
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QRS Complex Detection and Measurement Algorithms for Multichannel ECGs in Cardiac Resynchronization Therapy Patients
    Abstract We developed an automated approach for QRS complex detection and QRS duration (QRSd) measurement that can effectively analyze multichannel electrocardiograms (MECGs) acquired during abnormal conduction and pacing in heart failure and cardiac resynchronization therapy (CRT) patients to enable the use... Read more
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A Locomotion Control Platform with Dynamic Electromagnetic Field for Active Capsule Endoscopy
   Abstract Conventional radiological and endoscopic techniques utilizing long tubes were ineffective in visualizing the small bowel mucosa until the development of Wireless Capsule Endoscopy (WCE). WCE is a revolutionary endoscopic technology that can diagnose the complete gastrointestinal (GI) tract. However, the... Read more
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A Novel System to Measure Infants’ Nutritive Sucking During Breastfeeding: the Breastfeeding Diagnostic Device (BDD)
   Abstract Sucking microstructure is defined as an array of metrics that comprehensively capture infants’ ability to create a sealed latch onto mother’s nipple and regulate feeding, including number of sucks, sucks per burst, number of bursts, intra suck interval, and maximal... Read more
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Automatic Lung Segmentation with Juxta-Pleural Nodule Identification using Active Contour Model and Bayesian Approach
     Objective: Chest computed tomography (CT) images and their quantitative analyses have become increasingly important for a variety of purposes, including lung parenchyma density analysis, airway analysis, diaphragm mechanics analysis, and nodule detection for cancer screening. Lung segmentation is an important... Read more
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A Multi-Anatomical Retinal Structure Segmentation System for Automatic Eye Screening Using Morphological Adaptive Fuzzy Thresholding
   Abstract Eye exams can be as efficacious as physical ones in determining health concerns. Retina screening can be the very first clue to detecting a variety of hidden health issues including pre-diabetes and diabetes. Through the process of clinical diagnosis and... Read more
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An IoT-Enabled Stroke Rehabilitation System Based On Smart Wearable Armband And Machine Learning
            Part of the Special Issue on Advanced Internet of Things in Personalized Healthcare Systems: Validation, Analysis and Utilization Abstract Surface electromyography signal plays an important role in hand function recovery training. In this paper, an IoT-enabled stroke rehabilitation system was introduced which... Read more
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A Community-based IoT Personalized Wireless Healthcare Solution Trial
     Part of the Special Issue on Advanced Internet of Things in Personalized Healthcare Systems: Validation, Analysis and Utilization This paper presents an advanced Internet of Things point-of-care bio-fluid analyzer; a LoRa/Bluetooth-enabled electronic reader for biomedical strip-based diagnostics system for personalized monitoring.... Read more
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Developing a Policy Flight Simulator to Facilitate the Adoption of an Evidence-based Intervention
       Abstract While the use of evidence-based interventions (EBIs) has been advocated by the medical research community for quite some time, uptake of these interventions by healthcare providers has been slow. One possible explanation is that it is challenging for providers to... Read more
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Enabling Stroke Rehabilitation in Home and Community Settings: A Wearable Sensor-Based Approach for Upper-Limb Motor Training
        Abstract High-dosage motor practice can significantly contribute to achieving functional recovery after a stroke. Performing rehabilitation exercises at home and using, or attempting to use, the stroke-affected upper limb during Activities of Daily Living (ADL) are effective ways to achieve high-dosage... Read more
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Algorithms for monitoring heart rate and respiratory rate from the video of a user’s face
  Abstract Smartphone cameras can measure heart rate (HR) by detecting pulsatile photoplethysmographic (iPPG) signals from post-processing the video of a subject’s face. The iPPG signal is often derived from variations in the intensity of the green channel as shown by Poh... Read more
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Precision of EM Simulation based Wireless Location Estimation in Multi-Sensor Capsule Endoscopy
     Abstract In this paper, we compute and examine two-way localization limits for an RF endoscopy pill as it passes through an individuals gastrointestinal (GI) tract. We obtain finite-difference time-domain and finite element method-based simulation results position assessment employing time of arrival... Read more
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Histogram-Based Features Selection and Volume Of Interest Ranking For Brain PET Image Classification
    Abstract Positron emission tomography (PET) is a molecular medical imaging modality which is commonly used for neurodegenerative diseases diagnosis. Computer-aided diagnosis, based on medical image analysis, could help quantitative evaluation of brain diseases such as Alzheimer’s disease (AD). A novel method... Read more
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An Alternative Myoelectric Pattern Recognition Approach for the Control of Hand Prostheses: A Case Study of Use in Daily Life by a dysmelia subject
      Abstract The functionality of upper limb prostheses can be improved by intuitive control strategies that use bioelectric signals measured at the stump level. One such strategy is the decoding of motor volition via myoelectric pattern recognition (MPR), which has shown promising... Read more
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Clinician-Driven Design of VitalPAD – Intelligent Monitoring & Communication Device to Improve Patient Safety in the Intensive Care Unit
          The pediatric intensive care unit (ICU) is a complex environment, in which a multidisciplinary team of clinicians (registered nurses, respiratory therapists, and physicians) continually observe and evaluate patient information. Data are provided by multiple, and often physically separated sources, cognitive... Read more
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Physiological Recording in the MRI Environment (PRiME): MRI-Compatible Hemodynamic Recording System
          Hemodynamic recording during interventional cardiovascular procedures is essential for procedural guidance, monitoring patient status, and collection of diagnostic information. Recent advances have made interventions guided by magnetic resonance imaging (MRI) possible and attractive in certain clinical scenarios. However, in the... Read more
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Mastication Evaluation with Unsupervised Learning: Using an Inertial Sensor-Based System
     Abstract There is a direct relationship between the prevalence of musculoskeletal disorders of the temporomandibular joint and orofacial disorders. A well-elaborated analysis of the jaw movements provides relevant information for healthcare professionals to conclude their diagnosis. Different approaches have been explored... Read more
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Evaluation of Ventilation-Induced Lung Inflammation through Multiscale Simulations
   Ventilation-induced lung injury is a common problem faced by patients with respiratory problems who require mechanical ventilation (MV). This injury may lead to a greater chance of developing or exacerbating the acute respiratory distress syndrome which further complicates the therapeutic... Read more
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Detection of Essential Tremor at the S-Band
           Essential tremor (ET) is a neurological disorder characterized by rhythmic, involuntary shaking of a part or parts of the body. The most common tremor is seen in the hands/arms and fingers. This paper presents an evaluation of ETs monitoring based... Read more
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Effectively Measuring Respiratory Flow with Portable Pressure Data using Back Propagation Neural Network
       Abstract Continuous respiratory monitoring is an important tool for clinical monitoring. The most widely used flow measure device is nasal cannulae connected to a pressure transducer. However, most of these devices are not easy to carry and continue working in uncontrolled... Read more
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Passive Radar for Opportunistic Monitoring in e-Health Applications
   This paper proposes a passive Doppler radar as a non-contact sensing method to capture human body movements, recognize respiration, and physical activities in e-Health applications. The system uses existing in-home wireless signal as the source to interpret human activity. This... Read more
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CHOBS: Color Histogram of Block Statistics for Automatic Bleeding Detection in Wireless Capsule Endoscopy Video
   Wireless capsule endoscopy (WCE) is the most advanced technology to visualize whole gastrointestinal (GI) tract in a non-invasive way. But the major disadvantage here, it takes long reviewing time, which is very laborious as continuous manual intervention is necessary. In... Read more
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A Meshfree Representation for Cardiac Medical Image Computing
        The prominent advantage of meshfree method, is the way to build the representation of computational domain, based on the nodal points without any explicit meshing connectivity. Therefore, meshfree method can conveniently process the numerical computation inside interested domains with large... Read more
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Design of a Continuous Blood Pressure Measurement System Based on Pulse Wave and ECG Signals
        Part of the Special Issue on Advanced Internet of Things in Personalized Healthcare Systems: Validation, Analysis and Utilization Abstract With increasingly fierce competition for jobs, the pressures on people have risen in recent years, leading to lifestyle and diet disorders that result... Read more
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A Knowledge-Based Approach to Automatic Detection of Equipment Alarm Sounds in a Neonatal Intensive Care Unit Environment
       A large number of alarm sounds triggered by biomedical equipment occur frequently in the noisy environment of a neonatal intensive care unit (NICU) and play a key role in providing healthcare. In this paper, our work on the development of... Read more
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Automatic Detection of Compensation during Robotic Stroke Rehabilitation Therapy
      Robotic stroke rehabilitation therapy can greatly increase the efficiency of therapy delivery. However, when left unsupervised, users often compensate for limitations in affected muscles and joints by recruiting unaffected muscles and joints, leading to undesirable rehabilitation outcomes. This paper aims... Read more
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Smartphone Based Point-of-Care Urinalysis Under Variable Illumination
     Urine tests are performed by using an off-the-shelf reference sheet to compare the color of test strips. However, the tabular representation is difficult to use and more prone to visual errors, especially when the reference color-swatches to be compared are... Read more
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Development of a Non-Invasive Blink Reflexometer
       Qualitative assessments of the blink reflex are used clinically to assess neurological status in critical care, operating room, and rehabilitative settings. Despite decades of literature supporting the use of quantitative measurements of the blink reflex in the evaluation of multiple... Read more
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Electromechanically Actuated Multifunctional Wireless Auxetic Device for Wound Management
     The design and fabrication of a wound healing device for chronic wounds, with multiple functions for controlled drug delivery and exudate removal, has been described in this paper. The structural features have been machined and modified through laser cutting in... Read more
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Spectro-Temporal Electrocardiogram Analysis for Noise-Robust Heart Rate and Heart Rate Variability Measurement
   The last few years has seen a proliferation of wearable electrocardiogram (ECG) devices in the market with applications in fitness tracking, patient monitoring, athletic performance assessment, stress and fatigue detection, and biometrics, to name a few. The majority of these... Read more
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Evaluation of Computer-Based Target Achievement Tests for Myoelectric Control
   Real-time evaluation of novel prosthetic control schemes is critical for translational research on artificial limbs. Recently, two computer-based, real-time evaluation tools, the target achievement control (TAC) test and the Fitts’ law test (FLT), have been proposed to assess real-time controllability.... Read more
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Efficient Cancer Detection Using Multiple Neural Networks
  We introduce a multi-tiered neural network architecture that accurately classifies malignant breast tissue from benign breast tissue The inspection of live excised tissue specimens to ascertain malignancy is a challenging task in dermatopathology and generally in histopathology. We introduce a portable... Read more
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The Role of Affordable, Point-of-Care Technologies for Cancer Care in Low-and Middle-Income Countries: A Review & Commentary
      As the burden of non-communicable diseases such as cancer continues to rise in low- and middle-income countries (LMICs), it is essential to identify and invest in promising solutions for cancer control and treatment. Point-of-care technologies (POCTs) have played critical roles... Read more
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Automated Assessment of Dynamic Knee Valgus and Risk of Knee Injury During the Single Leg Squat
    Many clinical assessment protocols of the lower limb rely on the evaluation of functional movement tests such as the single leg squat (SLS), which are often assessed visually. Visual assessment is subjective and depends on the experience of the clinician.... Read more
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The Inspired Sinewave Technique: A Comparison Study with Body Plethysmography in Healthy Volunteers
      The inspired sinewave technique is a noninvasive method to measure airway dead space, functional residual capacity, pulmonary blood flow, and lung inhomogeneity simultaneously. The purpose of this paper was to assess the repeatability and accuracy of the current device prototype... Read more
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Developing a Wireless, High Precision and Processing Speed Pulse Monitoring Headset Using Photoplethysmography
    In this paper, thorough improvement of pulse monitoring and analysis equipment with a headset structure is presented. In order to study the most suitable infrared wavelength for the acquisition of the pulse wave at the earlobe, Monte Carlo simulation was... Read more
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Simultaneous Tracking of Cardiorespiratory Signals for Multiple Persons Using a Machine Vision System with Noise Artifact Removal
  Most existing non-contact monitoring systems are limited to detecting physiological signs from a single subject at a time. Still, another challenge facing these systems is that they are prone to noise artifacts resulting from motion of subjects, facial expressions, talking,... Read more
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Texture Feature Variability in Ultrasound Video of the Atherosclerotic Carotid Plaque
     The objective of this paper was to investigate texture feature variability in ultrasound video of the carotid artery during the cardiac cycle in an attempt to define new discriminatory biomarkers of the vulnerable plaque. More specifically, in this paper, 120... Read more
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Detecting Dementia through Interactive Computer Avatars
       This paper proposes a new approach to automatically detect dementia. Even though some works have detected dementia from speech and language attributes, most have applied detection using picture descriptions, narratives, and cognitive tasks. In this paper, we propose a new... Read more
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Pain Prediction from ECG in Vascular Surgery
      This Article is Featured in the Special Issue NIH-IEEE POCT 2016 Varicose vein surgeries are routine outpatient procedures, which are often performed under local anaesthesia. The use of local anaesthesia both minimises the risk to patients and is cost effective, however,... Read more
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Towards a Personalized Real-Time Diagnosis in Neonatal Seizure Detection
      The problem of creating a personalized seizure detection algorithm for newborns is tackled in this paper. A probabilistic framework for semi-supervised adaptation of a generic patient-independent neonatal seizure detector is proposed. A system that is based on a combination of... Read more
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Managing Heart Failure at Home with Point-of-Care Diagnostics
      This Article is Featured in the Special Issue NIH-IEEE POCT 2016 The objective of this paper is development of an inexpensive point-of-care sensor for detecting the primary heart failure marker peptide, NT-proBNP. The device technology is based on an antibody sandwich... Read more
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A Software Tool for Heart AVJ Motion Tracking Using Cine Cardiovascular Magnetic Resonance (CMR) Images
      One important index to assess left ventricular diastolic function is the quantitative measurement of atrioventricular junction (AVJ) motion in one cardiac cycle including systole and diastole. The best way to perform the measurement is to use a software tool that... Read more
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Tissue Variability and Antennas for Power Transfer to Wireless Implantable Medical Devices
   The design of effective transcutaneous systems demands the consideration of inevitable variations in tissue characteristics, which vary across body areas, among individuals, and over time. The purpose of this paper was to design and evaluate several printed antenna topologies for... Read more
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Predicting Drug Recalls from Internet Search Engine Queries
Batches of pharmaceuticals are sometimes recalled from the market when a safety issue or a defect is detected in specific production runs of a drug. Such problems are usually detected when patients or healthcare providers report abnormalities to medical authorities.... Read more
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Seismocardiography-Based Cardiac Computed Tomography Gating Using Patient-Specific Template Identification and Detection
    To more accurately trigger cardiac computed tomography angiography (CTA) than electrocardiography (ECG) alone, a sub-system is proposed as an intermediate step toward fusing ECG with seismocardiography (SCG). Accurate prediction of quiescent phases is crucial to prospectively gating CTA, which is... Read more
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A New Wavelet-Based ECG Delineator for the Evaluation of the Ventricular Innervation
      T-wave amplitude (TWA) has been proposed as a marker of the innervation of the myocardium. Until now, TWA has been calculated manually or with poor algorithms, thus making its use not efficient in a clinical environment. We introduce a new... Read more
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Automatic Sleep Monitoring Using Ear-EEG
  The monitoring of sleep patterns without patient’s inconvenience or involvement of a medical specialist is a clinical question of significant importance. To this end, we propose an automatic sleep stage monitoring system based on an affordable, unobtrusive, discreet, and long-term... Read more
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Multi-Parameter Ensemble Learning for Automated Vertebral Body Segmentation in Heterogeneously Acquired Clinical MR Images
The development of quantitative imaging biomarkers in medicine requires automatic delineation of relevant anatomical structures using available imaging data. However, this task is complicated in clinical medicine due to the variation in scanning parameters and protocols, even within a single... Read more
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Wearable Improved Vision System for Color Vision Deficiency Correction
Color vision deficiency (CVD) is an extremely frequent vision impairment that compromises the ability to recognize colors. In order to improve color vision in a subject with CVD, we designed and developed a wearable improved vision system based on an... Read more
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A Multi-Classifier System for Automatic Mitosis Detection in Breast Histopathology Images using Deep Belief Networks
Mitotic count is an important diagnostic factor in breast cancer grading and prognosis. Detection of mitosis in breast histopathology images is very challenging mainly due to diffused intensities along object boundary and shape variation in different stages of mitosis. This... Read more
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Efficacy Evaluation of SAVE for the Diagnosis of Superficial Neoplastic Lesion
The detection of non-polypoid superficial neoplastic lesions using current standard of white light endoscopy surveillance and random biopsy is associated with high miss rate. The subtle changes in mucosa caused by the flat and depressed neoplasms often go undetected and... Read more
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Near-Infrared Imaging for Detecting Caries and Structural Deformities in Teeth
2-D radiographs, while commonly used for evaluating sub-surface hard structures of teeth, have low sensitivity for early caries lesions, particularly those on tooth occlusal surfaces. Radiographs are also frequently refused by patients over safety concerns. Translucency of teeth in the... Read more
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Non-invasive Radiofrequency Field Treatment to Produce Hepatic Hyperthermia: Efficacy and Safety in Swine
  The Kanzius non-invasive radiofrequency hyperthermia system (KNiRFH) has been investigated as a treatment option for hepatic hyperthermia cancer therapy. The treatment involves exposing the patient to an external high-power RF (13.56 MHz) electric field whereby the propagating waves penetrate deep... Read more
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Spatiotemporal Strategies for Joint Segmentation & Motion Tracking from Cardiac Image Sequences
Although accurate and robust estimations of the deforming cardiac geometry and kinematics from cine tomographic medical image sequences remain a technical challenge, they have significant clinical value. Traditionally, boundary or volumetric segmentation and motion estimation problems are considered as two... Read more
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A Versatile Ultrasound Simulation System for Education and Training in High-Fidelity Emergency Scenarios
Point of care ultrasonography and the related focused assessment with sonography for trauma protocol, if performed by experienced physicians, is a highly sensitive examination, and specific for the detection of free fluids. Different systems and methods have been proposed for... Read more
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Melanoma Is Skin Deep: A 3D Reconstruction Technique for Computerized Dermoscopic Skin Lesion Classification
This Article is Featured in the Special Issue NIH-IEEE POCT 2015 Melanoma mortality rates are the highest amongst skin cancer patients. Melanoma is life-threating when it grows beyond the dermis of the skin. Hence, depth is an important factor to diagnose... Read more
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Detection of Paroxysms in Long-Term, Single Channel EEG-Monitoring of Patients with Typical Absence Seizures
  Absence seizures are associated with generalized 2.5-5 Hz spike-wave discharges in the electroencephalogram (EEG). Rarely are patients, parents, or physicians aware of the duration or incidence of seizures. Six patients were monitored with a portable EEG-device over four times 24... Read more
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Patient-Specific Oscillometric Blood Pressure Measurement: Validation for Accuracy and Repeatability
Oscillometric devices are widely used for automatic cuff blood pressure (BP) measurement. These devices estimate BP from the oscillometric cuff pressure waveform using population average methods. Hence, the devices may only be accurate over a limited BP range. The objective... Read more
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Quantitative Analysis of Electro-Anatomical Maps: Application to an Experimental Model of LBBB/CRT
  Electro-anatomical maps (EAMs) are commonly acquired in clinical routine for guiding ablation therapies. They provide voltage and activation time information on a 3D anatomical mesh representation, making them useful for analyzing the electrical activation patterns in specific pathologies. However, the... Read more
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Low-Cost Sensor System Design for In-Home Physical Activity Tracking
An aging and more sedentary population requires interventions aimed at monitoring physical activity, particularly within the home. This research uses simulation, optimization, and regression analyses to assess the feasibility of using a small number of sensors to track movement and... Read more
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Sit-to-Stand Transition Reveals Acute Fall Risk in Activities of Daily Living
The focus of this paper was on finding wrist sensor-derived features for detecting highly acute fall risk from the sit-to-stand transitions performed in a non-ambulatory environment. Furthermore, the influence of the dominant and non-dominant hand on these features was investigated.... Read more
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Collaborative Paradigm of Preventive, Personalized and Precision Medicine with Point-of-Care Technologies
This Article is Featured in the Special Issue NIH-IEEE POCT 2015 Recent advances in biosensors, medical instrumentation, and information processing and communication technologies (ICT) have enabled significant improvements in healthcare. However, these technologies have been mainly applied in clinical environments, such... Read more
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A Comparison of Pattern Recognition Control and Direct Control of a Multiple Degree-of-Freedom Transradial Prosthesis
With existing conventional prosthesis control (direct control), individuals with a transradial amputation use two opposing muscle groups to control each prosthesis motor. As component complexity increases, subjects must switch the prosthesis into different modes to control each component in sequence.... Read more
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Effects of Real-World Versus Virtual Environments on Joint Excursions in Full-Body Reaching Tasks
Abstract Objective: Starting from an upright standing posture and reaching for a target that requires some forward bending of the trunk can involve many different configurations of the trunk and limb segments. We sought to determine if configurations of the limb... Read more
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Smart Helmet: Wearable Multichannel ECG & EEG
Modern wearable technologies have enabled continuous recording of vital signs, however, for activities such as cycling, motor-racing, or military engagement, a helmet with embedded sensors would provide maximum convenience and the opportunity to monitor simultaneously both the vital signs and... Read more
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Healthcare Commercialization Programs: Improving the Efficiency of Translating Healthcare Innovations From Academia Into Practice
Academic investigators are generating a plethora of insights and technologies that have the potential to significantly improve patient care. However, to address the imperative to improve the quality, cost and access to care with ever more constrained funding, the efficiency and the... Read more
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The Assessment of Stent Effectiveness Using a Wearable Beamforming MEMS Microphone Array System
Studies involving turbulent flow have been carried out in many parts of the cardiovascular system, and it has been widely reported that turbulence related to stenosis (narrowing) of arteries creates audible sounds, which may be analyzed to yield information about... Read more
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Inferior Breast-Chest Contour Detection in 3D Images of the Female Torso
Stereophotogrammetry is finding increased use in clinical breast surgery, both for breast reconstruction after oncological procedures and cosmetic augmentation and reduction. The ability to visualize and quantify morphological features of the breast facilitates pre-operative planning and post-operative outcome assessment. The... Read more
Articles
Non-Invasive Neuromodulation using Time-Varying Caloric Vestibular Stimulation
Caloric vestibular stimulation (CVS) to elicit the vestibulo-ocular reflex has long been used in clinical settings to aid in the diagnosis of balance disorders and to confirm the absence of brainstem function. While a number of studies have hinted at... Read more
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The National Institutes of Health Affordable Cancer Technologies Program: Improving Access to Resource-Appropriate Technologies for Cancer Detection, Diagnosis, Monitoring and Treatment in Low- and Middle-Income Countries
This Article is Featured in the Special Issue NIH-IEEE POCT 2015 Point-of-care (POC) technologies have proved valuable in cancer detection, diagnosis, monitoring, and treatment in the developed world, and have shown promise in low-and-middle-income countries (LMIC) as well. Despite this promise,... Read more
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Image-guided High Intensity Focused Ultrasound (HIFU) System for Large Animal Nerve Ablation Studies
High intensity focused ultrasound (HIFU) is a form of thermal ablation technique, which can treat a variety of medical afflictions. One promising therapeutic use is the permanent destruction of nerves non-invasively in patients with severe spasticity or certain types of... Read more
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A System for Simple Real-Time Anastomotic Failure Detection and Wireless Blood Flow Monitoring in the Lower Limbs
Current totally implantable wireless blood flow monitors are large and cannot operate alongside nearby monitors. To alleviate the problems with the current monitors, we developed a system to monitor blood flow wirelessly, with a simple and easily interpretable real-time output.... Read more
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Summary of Human Ankle Mechanical Impedance During Walking
The human ankle joint plays a critical role during walking and understanding the biomechanical factors that govern ankle behavior and provides fundamental insight into normal and pathologically altered gait. Previous researchers have comprehensively studied ankle joint kinetics and kinematics during... Read more
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The Utility of Cloud Computing in Analyzing GPU-Accelerated Deformable Image Registration of CT and CBCT Images in Head and Neck Cancer Radiation Therapy
Abstract: The images generated during radiation oncology treatments provide a valuable resource to conduct analysis for personalized therapy, outcomes prediction, and treatment margin optimization. Deformable image registration (DIR) is an essential tool in analyzing these images. We are enhancing and examining... Read more
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National Institute of Biomedical Imaging and Bioengineering Point-of-Care Technology Research Network: Advancing Precision Medicine
This Article is Featured in the Special Issue NIH-IEEE POCT 2015 To advance the development of point-of-care technology (POCT), the National Institute of Biomedical Imaging and Bioengineering established the POCT Research Network (POCTRN), comprised of Centers that emphasize multidisciplinary partnerships and... Read more
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The Importance of State and Context in Safe Interoperable Medical Systems
This Article is Featured in the Special Issue NIH-IEEE POCT 2015 This paper describes why “device state” and “patient context” information are necessary components of device models for safe interoperability. This paper includes a discussion of the importance of describing the... Read more
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Analysis of Difference in Center-of-Pressure Positions Between Experts and Novices During Asymmetric Lifting
Although numerous studies have analyzed the relationship between manual material handling (MMH) and the forces acting on the lumbar spine, the difference in the MMH between experts and novices through the analysis of measured data has not been well studied.... Read more
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Point-of-Care Technologies for the Advancement of Precision Medicine in Heart, Lung, Blood, and Sleep Disorders
A discussion of the importance of point-of-care (POC) technologies in facilitating precision medicine for heart, lung, blood, and sleep disorders, including three such technologies currently undergoing commercialization. The commercialization of new point of care technologies holds great potential in facilitating and... Read more
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Guiding Empiric Treatment for Serious Bacterial Infections via Point of Care B-Lactamase Characterization
For suspected serious bacterial infection in infants, ampicillin administration is a standard treatment (left panel). However, patients with a β-lactamase positive infection may be resistant to this treatment. As delays in effective treatment are correlated with poor patient outcome, rapid... Read more
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Optical Cryoimaging Reveals a Heterogeneous Distribution of Mitochondrial Redox State in ex vivo Guinea Pig Hearts and its Alteration during Ischemia and Reperfusion
Objective: Oxidation of substrates to generate ATP in mitochondria is mediated by redox reactions of NADH and FADH2. Cardiac ischemia and reperfusion (IR) injury compromises mitochondrial oxidative phosphorylation. We hypothesize that IR alters the metabolic heterogeneity of mitochondrial redox state... Read more
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Spatial Heterogeneity Analysis in Evaluation of Cell Viability and Apoptosis for Colorectal Cancer Cells
In evaluation of cell viability and apoptosis, spatial heterogeneity is quantified for cancerous cells cultured in 3D in-vitro cell-based assays under the impact of anti-cancer agents. In 48-hour experiments using human colorectal cancer cell lines of HCT-116, SW-620 and SW-480,... Read more
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A Smart-home System to Unobtrusively and Continuously Assess Loneliness in Older Adults
Loneliness is a common condition in older adults and is associated with increased morbidity and mortality, decreased sleep quality, and increased risk of cognitive decline. Assessing loneliness in older adults is challenging due to the negative desirability biases associated with... Read more
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More Than Just Accuracy: A Novel Method to Incorporate Multiple Test Attributes in Evaluating Diagnostic Tests Including Point of Care Tests
Current frameworks for evaluating diagnostic tests are constrained by a focus on diagnostic accuracy, and assume that all aspects of the testing process and test attributes are discrete and equally important. Determining the balance between the benefits and harms associated... Read more
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Assessment of Carbon/Salt/Adhesive Electrodes for Surface Electromyography Measurements
This work presents the evaluation of novel electrodes for surface electromyography (sEMG) measurements. The electrodes are based on a mixture of carbon powder, quaternary salt and viscoelastic polymeric adhesive (carbon/salt/adhesive or simply CSA), which when combined, provide the unique advantages... Read more
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Design and Application of a New Automated Fluidic Visceral Stimulation Device for Human fMRI Studies of Interoception
Mapping the brain centers that mediate the sensory-perceptual processing of visceral afferent signals arising from the body (i.e., interoception) is useful both for characterizing normal brain activity and for understanding clinical disorders related to abnormal processing of visceral sensation such... Read more
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Comparative Study of Wavelet Based Unsupervised Ocular Artifact Removal Techniques for Single Channel EEG Data
Electroencephalogram (EEG) is a technique for recording asynchronous activation of neuronal firing inside the brain with non-invasive scalp electrodes. Artifacts such as eye blink activities can corrupt these neuronal signals. While ocular artifact (OA) removal is well investigated for multiple... Read more
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Elucidating the Hemodynamic Origin of Ballistocardiographic Forces: Towards Improved Monitoring of Cardiovascular Health at Home
The ballistocardiogram (BCG), a signal describing the reaction forces of the body to cardiac ejection of blood, has recently gained interest in the research community as a potential tool for monitoring the mechanical aspects of cardiovascular health for patients at... Read more
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OB CITY – Definition of a Family-Based Intervention for Childhood Obesity Supported by Information and Communication Technologies
Childhood obesity is becoming one of the 21st century’s most important public health problems. Nowadays, the main treatment of childhood obesity is behavior intervention that aims at improve children’s lifestyle to arrest the disease. Information and communication technologies (ICTs) have... Read more
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I-maculaweb: A Tool to Support Data Reuse in Ophthalmology
The paper intends to present a web-based application to collect and manage clinical data and clinical trials together in a unique tool. I-maculaweb is a user-friendly web-application designed to manage, share, and analyze clinical data from patients affected by degenerative... Read more
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Intra- and Inter-Fractional Variation Prediction of Lung Tumors using Fuzzy Deep Learning
Tumor movements should be accurately predicted to improve delivery accuracy and reduce unnecessary radiation exposure to healthy tissue during radiotherapy. The tumor movements pertaining to respiration are divided into intra-fractional variation occurring in a single treatment session and inter-fractional variation... Read more
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The Effects of Radiofrequency or Cryothermal Ablation on Biomechanical Properties of Isolated Human or Swine Cardiac Tissues
Changes in cardiac tissue properties following the application of various ablation modalities may lead to the development of an array of associated complications. The application of either radiofrequency (RF) or cryothermal ablations will alter the biomechanical properties of various cardiac... Read more
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Extraction of Stride Events from Gait Accelerometry During Treadmill Walking
Objective: Evaluating stride events can be valuable for understanding the changes in walking due to aging and neurological diseases. However, creating the time series necessary for this analysis can be cumbersome. In particular, finding heel contact and toe-off events which... Read more
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Smartphone based realtime assessment of swallowing ability from the swallowing sound
Dysphagia can cause serious challenges to both physical and mental health. Aspiration due to dysphagia is a major health risk that could cause pneumonia and even death. The videofluoroscopic swallow study or VFSS, which is considered the gold standard for... Read more
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A Transform-Based Feature Extraction Approach for Motor Imagery Tasks Classification
In this paper, we present a new motor imagery classification method in the context of electroencephalography (EEG)-based brain–computer interface (BCI). This method uses a signal-dependent orthogonal transform, referred to as linear prediction singular value decomposition (LP-SVD), for feature extraction. The... Read more
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Development of a Standard Protocol for the Harmonic Analysis of Radial Pulse Wave and Assessing its Reliability in Healthy Humans
This study was aimed to establish a standard protocol and to quantitatively assess the reliability of harmonics analysis of the radial pulse wave measured by Harmonic wave analyzer-TD01C system. Both intra-observer and inter-observer assessments was conducted to investigate whether the... Read more
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Health Informatics for Neonatal Intensive Care Units: An Analytical Modeling Perspective
The effective use of data within intensive care units (ICUs) has great potential to create new cloud-based health analytics solutions for disease prevention or earlier condition onset detection. The Artemis project aims to achieve the above goals in the area... Read more
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Using Smartphone Sensors for Improving Energy Expenditure Estimation
Energy Expenditure (EE) estimation is an important factor in tracking personal activity and preventing chronic diseases such as obesity and diabetes. Accurate and real-time EE estimation utilizing small wearable sensors is a difficult task, primarily because most existing schemes work... Read more
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Assessing the relative integrity of formed cardiac linear lesions by recording both focal monophasic action potentials and contact forces: a technical brief
The use of therapeutic ablation in patients with atrial fibrillation has become a mainstay in the treatment of this disease, yet often these individuals require multiple procedures. In other words, successful first time treatments are impacted by challenges including the... Read more
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Analyzing Systolic–Diastolic Interval Interaction Characteristics in Diabetic Cardiac Autonomic Neuropathy Progression
This paper proposes an ECG based measure for analysing Cardiac autonomic Neuropathy (CAN) related alteration in the temporal synchronization of left ventricle function (i.e. Systolic-diastolic interval interaction (SDI)). The measure was validated in diabetic CAN progression using three subject groups... Read more
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An Ontology for Telemedicine Systems Resiliency to Technological Context Variations in Pervasive Healthcare
Part of the JTEHM BHI 2014 Special Issue. This paper presents an ontology for a quality of data (QoD) framework that enables the development of QoD-aware telemedicine systems in pervasive healthcare, where quality control entities are missing. The resulting system is... Read more
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neuroBi: A Highly Configurable Neurostimulator for a Retinal Prosthesis and Other Applications
This paper presents an innovative neurostimulator for use with a suprachoroidal retinal prosthesis. Clinical test results are described which show it to be effective in eliciting visual percepts in a profoundly vision-impaired subject with approximately 20 years of light perception... Read more
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A Comparison of Ultrasound Intima-media Thickness Measurements of the Left and Right Common Carotid Artery
The intima-media (IMT) thickness of the common carotid artery is an established indicator of cardiovascular disease, and the difference between the left and the right sides of the CCA IMT may have important implications for cardiovascular disease diagnosis and management.... Read more
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Computer Vision Techniques for Transcatheter Intervention
This paper provides a comprehensive review for researchers of computer vision techniques and methodologies in transcatheter intervention. Minimally invasive transcatheter technologies have demonstrated substantial promise for the diagnosis and the treatment of cardiovascular diseases. For example, transcatheter aortic valve implantation is... Read more
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Technical validation of ARTSENS – An image free device for evaluation of vascular stiffness
Vascular stiffness is an indicator of cardiovascular health, with carotid artery stiffness having established correlation to coronary heart disease and utility in cardiovascular diagnosis and screening. State of art equipment for stiffness evaluation are expensive, require expertise to operate and... Read more
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Integration of New Technology for Research in the Emergency Department: Feasibility of Deploying a Robotic Assessment Tool for Mild Traumatic Brain Injury Evaluation
This paper demonstrates the effective deployment of a robotic assessment tool for evaluation of mild Traumatic Brain Injury patients in a busy, resource-constrained, urban Emergency Department (ED). Over 14 months, 1423 patients were screened and 42 of them completed both... Read more
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Brain Cooling With Ventilation of Cold Air Over Respiratory Tract in Newborn Piglets: an Experimental and Numerical study
This paper investigates thermal effects of pulmonary cooling which was induced by cold air through an endotracheal tube via a ventilator on newborn piglets. We demonstrated that pulmonary cooling by cooling of inhalation gases immediately before they enter the trachea... Read more
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Automated Health Alerts Using In-Home Sensor Data for Embedded Health Assessment
This paper proposes a model for early detection of health decline in seniors using personalized normals and continuous in-home monitoring with embedded sensors. Sensors embedded in senior housing apartments unobtrusively capture behavior and activity patterns. Changes in patterns are detected... Read more
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Noninvasive Real-Time Automated Skin Lesion Analysis System for Melanoma Early Detection and Prevention
This figure shows a few steps of the proposed dermoscopy image analysis system (a) iPhone dermotoscope, up to 20x magnification. (b) Sample of skin lesion, including normal lesion (first column), melanoma lesion (second column) and atypical lesion (third column). (c)... Read more
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Automatic Real-time Embedded QRS Complex Detection for a Novel Patch-Type Electrocardiogram Recorder
The design and optimization of our novel automatic QRS complex detection algorithm was performed on two different databases: The MIT-BIH Arrhythmia Database (Se=99.90%, P+=99.87) and a private ePatch Training Database (Se=99.88%, P+=99.37%). The algorithm is based on a novel cascade of computationally efficient... Read more
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Current and Future Challenges in Point-of-Care Technologies: A Paradigm-Shift in Affordable Global Healthcare With Personalized and Preventive Medicine
This paper summarizes the panel discussion at the IEEE Engineering in Medicine and Biology Point-of-Care Healthcare Technology Conference (POCHT 2013) held in Bangalore India from Jan 16–18, 2013. Modern medicine has witnessed interdisciplinary technology innovations in healthcare with a continuous... Read more
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Engineering a High-Throughput 3D in vitro Glioblastoma Model
Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumor in adults. The existing treatment for GBM, which involves a combination of resection, chemotherapy and radiotherapy, has a very limited success rate with a median survival rate of... Read more
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An Optokinetic Nystagmus Detection Method for Use with Young Children
, , The detection of vision problems in early childhood can prevent neuro-developmental disorders such as amblyopia. However, accurate clinical assessment of visual function in young children is challenging. Optokinetic Nystagmus (OKN) is a reflexive sawtooth motion of the eye... Read more
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An Integrated Model of Patient and Staff Satisfaction Using Queuing Theory
This paper investigates the connection between patient satisfaction, waiting time, staff satisfaction and service time. It uses a variety of models to enable improvement against experiential and operational health service goals. Patient satisfaction levels are estimated using a model based... Read more
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Principal Dynamic Mode Analysis of EEG Data for Assisting the Diagnosis of Alzheimer’s Disease
We examine whether modeling of the causal dynamic relationships between frontal and occipital electroencephalogram (EEG) time-series recordings reveal reliable differentiating characteristics of Alzheimer’s patients versus control subjects in a manner that may assist clinical diagnosis of Alzheimer’s disease (AD). The... Read more
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Development of Point of Care Testing Device for Neurovascular Coupling from Simultaneous Recording of EEG and NIRS During Anodal Transcranial Direct Current Stimulation
This paper presents a point-of-care testing device for bedside measurement of cerebral blood flow and cerebrovascular reserve. The device detects neurovascular coupling (NVC) from simultaneous recording of electroencephalogram and near infra red spectroscopy during anodal transcranial direct current stimulation (tDCS).... Read more
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Automated Lung Segmentation and Image Quality Assessment for Clinical 3-D/4-D-Computed Tomography
4-dimensional computed tomography (4DCT) provides not only a new dimension of patient-specific information for radiation therapy planning and treatment but also a challenging scale of data volume to process and analyze. Manual analysis using existing 3D tools is unable to... Read more
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Identifying Cancer Biomarkers From Microarray Data Using Feature Selection and Semisupervised Learning
Microarrays have now gone from obscurity to being almost ubiquitous in biological research. At the same time, the statistical methodology for microarray analysis has progressed from simple visual assessments of results to novel algorithms for analyzing changes in expression profiles.... Read more
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Design, Fabrication and Experimental Validation of Novel Flexible Silicon-based Dry Sensors for Electroencephalography Signal Measurements
(A) Length and width of the forehead-SBDS electrode are 15 mm in each dimension. Five electrodes are embedded in the forehead-SBDS substrate. (B) Thickness of the forehead-SBDS substrate is approximately 0.8~1 mm. (C) Dimensions of the acicular-SBDS. Many electroencephalography (EEG) sensors,... Read more
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Monitoring and Analysis of Respiratory Patterns Using Microwave Doppler Radar
Non-contact detection characteristic of Doppler radar provides an unobtrusive means of respiration detection and monitoring. This avoids additional preparations such as physical sensor attachment or special clothing which can be useful for certain healthcare applications. Furthermore, robustness of Doppler radar... Read more
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Automatic Detection and Classification of Unsafe Events during Power Wheelchair Use
Using a powered wheelchair (PW) is a complex task requiring advanced perceptual and motor control skills. We develop technological tools that can be used to characterize a PW user’s driving behavior using recordings from a datalogging platform that records, in... Read more
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The Effect of Light Conditions on Photoplethysmographic Image Acquisition Using a Commercial Camera
The waveform of the photoplethysmographic image (PPGi) signals may be significantly affected by the light spectra and intensity. The purpose of this study is to evaluate the performance of PPGi aveform acquisition in the red, green and blue channels using... Read more
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A Bayesian Algorithm for Anxiety Index Prediction Based on Cerebral Blood Oxygenation in the Prefrontal Cortex Measured by Near Infrared Spectroscopy
Stress-induced psychological and somatic diseases are virtually endemic nowadays. Written self-report anxiety measures are available; however, these indices tend to be time consuming to acquire. For medical patients, completing written reports can be burdensome if they are weak, in pain,... Read more
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Pre to Intraoperative Data Fusion Framework for Multimodal Characterization of Myocardial Scar Tissue
Merging multimodal information about myocardial scar tissue can help electrophysiologists to find the most appropriate target during catheter ablation of ventricular arrhythmias. A framework is presented to analyze and combine information from delayed enhancement magnetic resonance imaging (DE-MRI) and electro-anatomical... Read more
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Controlling knee swing initiation and ankle plantarflexion with an active prosthesis on level and inclined surfaces at variable walking speeds
Improving lower-limb prostheses is important to enhance the mobility of amputees. The purpose of this study was to introduce an impedance-based control strategy (consisting of four novel algorithms) for an active knee and ankle prosthesis and test its generalizability across... Read more
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Experimental Procedure for Determination of the Dielectric Properties of Biological Samples in the 2-50 GHz Range
This study evaluated an experimental procedure for providing data on the complex permittivity of different cell lines in the 2-50 GHz range at room temperature, for the purpose of future dosimetric studies. The complex permittivity measurements were performed on cells... Read more
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High-Frequency Oscillations Recorded on the Scalp of Patients with Epilepsy Using Tripolar Concentric Ring Electrodes
Panel B shows 12 minutes of bipolar EEG from Fp2-F4 (1-70 Hz, 200 S/s). Panel A is the corresponding spectrogram. Panel E shows 30 seconds of EEGfrom Panel B at the onset of the generalized seizure (dashed line). Panels C,... Read more
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Effective CPR Procedure with Real Time Evaluation and Feedback Using Smartphones
Timely CPR can mean the difference between life and death. A trained person may not be available at emergency sites to give CPR. Normally, a 9-1-1 operator gives verbal instructions over the phone to a person giving CPR. In this... Read more
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μ-Foil Polymer Electrode Array for Intracortical Neural Recordings
We have developed a multichannel electrode array, termed μ-foil, that comprises ultrathin and flexible electrodes protruding from a thin foil at fixed distances. This study is an early evaluation of technical aspects and performance of this electrode array in acute... Read more
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A Remote-Controlled Airbag Device Can Improve Upper Airway Collapsibility by Producing Head Elevation with Jaw Closure in Normal Subjects Under Propofol Anesthesia
The photograph in one sample of sniffing position given by an airbag device. Objective: Continuous maintenance of an appropriate position of the mandible and head purely by manual manipulation is difficult, although the maneuver can restore airway patency during sleep and... Read more
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Urine Flow Dynamics Through Prostatic Urethra With Tubular Organ Modeling Using Endoscopic Imagery
Voiding dysfunction is common in the aged male population. However, the obstruction mechanism in the lower urinary tract and critical points for obstruction remains uncertain. The aim of this paper was to develop a system to investigate the relationship between... Read more
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A Method to Standardize Quantification of Left Atrial Scar From Delayed-Enhancement MR Images
Figure shows a heat map of the left atrium, generated from the algorithm, showing likely areas of scar. Purple stylized dots represent potential sites of ablation based on the scar distribution. Standardization of quantification for left-atrial scar will allow the selection... Read more
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An Adaptive Home-Use Robotic Rehabilitation System for the Upper Body
Robotic rehabilitation systems have been developed to treat these musculoskeletal conditions, but limited availability prevents most patients from using them. The objective of this research was to create a home-use robotic rehabilitation system. Data was obtained in real-time from a Microsoft... Read more
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Development of a Compact Rectenna for Wireless Powering of a Head-mountable Deep Brain Stimulation Device
Design of a rectangular spiral planar inverted-F antenna (PIFA) at 915 MHz for wireless power transmission applications is proposed. The antenna and the rectifying circuitry form a rectenna which can produce DC power from a distant radio frequency energy transmitter.... Read more
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Acoustic Analysis of Inhaler Sounds from Community-Dwelling Asthmatic Patients for Automatic Assessment of Adherence
Audio signal (a) and corresponding spectrogram (b) of Diskus™ inhaler use showing the blister, exhalation and inhalation events. Inhalers are devices which deliver medication to the airways in the treatment of chronic respiratory diseases. When used correctly inhalers relieve and improve... Read more
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FingerSight: Fingertip Haptic Sensing of the Visual Environment
The FingerSight device We present a novel device mounted on the fingertip for acquiring and transmitting visual information through haptic channels. In contrast to previous systems in which the user interrogates an intermediate representation of visual information, such as a tactile... Read more
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In Vivo Brain Magnetic Resonance Spectroscopy: A Measurement of Biomarker Sensitivity to Post-Processing Algorithms
MR brain spectroscopy biomarkers are diagnostic for a wide variety of neurological disorders. Although rarely discussed in detail in the literature, reported biomarkers depend upon parameters for several algorithms that serially mitigate distortions and allow biomarkers to demonstrate statistical significance.... Read more
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RFID Tag Helix Antenna Sensors for Wireless Drug Dosage Monitoring
Illustration of the proposed real time drug delivery monitoring system. Utilizing the antenna drug dosage sensors, a smart phone can track the drug volume in multiple drug delivery devices. Miniaturized helix antennas are integrated with drug reservoirs to function as RFID... Read more
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Novel System for Real-Time Integration of 3-D Echocardiography and Fluoroscopy for Image-Guided Cardiac Interventions: Preclinical Validation and Clinical Feasibility Evaluation
A novel, validated image fusion system that allows real-time integration of three-dimensional echocardiography and X-ray fluoroscopy for guidance of cardiac cacheterization. The system was validated in two stages: pre-clinical to determine function and validate accuracy, and in the clinical setting... Read more
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Hardware Development and Locomotion Control Strategy for an Over-Ground Gait Trainer: NaTUre-Gaits
Design and validation of an over-ground gait rehabilitation system, NaTUre-gaits, that predicts individual-specific gait patterns for a more natural walking rhythm. Preliminary tests show that NaTUre-gaits provides reduction in manpower, successful task-specific repetitive training and natural walking gait patterns. Therapist-assisted body... Read more
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Quantitative Assessment of Single-Image Super-Resolution in Myocardial Scar Imaging
A novel, validated image fusion system that allows real-time integration of three-dimensional echocardiography and X-ray fluoroscopy for guidance of cardiac cacheterization. The system was validated in two stages: pre-clinical to determine function and validate accuracy, and in the clinical setting... Read more
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Constrained TpV-minimization for Enhanced Exploitation of Gradient Sparsity: Application to CT Image Reconstruction
Exploiting sparsity in the image gradient magnitude has proved to be an effective means for reducing the sampling rate in the projection view angle in computed tomography (CT). Most of the image reconstruction algorithms developed for this purpose solve a... Read more
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Spatial Mutual Information as Similarity Measure for 3D Brain Image Registration
Information theoretic-based similarity measures, in particular mutual information, are widely used for intermodal/intersubject 3D brain image registration. However, conventional mutual information does not take into account spatial dependency between adjacent voxels in images thus reducing its efficacy as a similarity... Read more
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Accurate and Fully Automatic Hippocampus Segmentation Using Subject-specific 3D Optimal Local Maps into a Hybrid ActiveContour Model
Assessing the structural integrity of the hippocampus (HC) is an essential step towards prevention, diagnosis and follow-up of various brain disorders due to the implication of the structural changes of HC in those disorders. In this respect, the development of... Read more
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A Device for Local or Remote Monitoring of Hand Rehabilitation Sessions for Rheumatic Patients
Current clinical practice suggests that recovering the hand functionality lost or reduced by injuries, interventions and chronic diseases requires, beyond pharmacological treatments, a kinesiotherapic intervention. This form of rehabilitation consists of physical exercises adapted to the specific pathology. Its effectiveness... Read more
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Gastric Contraction Imaging System Using a Three-Dimensional Endoscope
This paper presents a gastric contraction imaging system for assessment of gastric motility using a three-dimensional endoscope. Gastrointestinal diseases are mainly based on morphological abnormalities. However, gastrointestinal symptoms are sometimes apparent without visible abnormalities. One of the major factors for... Read more
Articles, Published Articles
Detection of Cardiac Quiescence from B-Mode Echocardiography using a Correlation-Based Frame-to-Frame Deviation Measure
Two novel methods for detecting cardiac quiescent phases from B-mode echocardiography using a correlation-based frame-to-frame deviation measure were developed. Accurate knowledge of cardiac quiescence is crucial to the performance of many imaging modalities, including computed tomography coronary angiography (CTCA). Methods:... Read more
Articles, Published Articles
icuARM – An ICU Clinical Decision Support System Using Association Rule Mining
The rapid development of biomedical monitoring technologies has enabled modern intensive care units (ICUs) to gather vast amounts of multimodal measurement data about their patients. However, processing large volumes of complex data in real-time has become a big challenge. Together... Read more
Articles, Published Articles
Eye Tracking and Head Movement Detection: A State-of-Art Survey
This paper presents a state-of-art survey of eye tracking and head movement detection methods proposed in the literature. Eye-gaze detection and tracking have been an active research field in the past years as it adds convenience to a variety of applications.... Read more
Articles, Published Articles
Novel Flurometric Tool to Assess Mitochondrial Redox State of Isolated Perfused Rat Lungs after Exposure to Hyperoxia
Recently we demonstrated the utility of optical fluorometry to detect a change in the redox status of mitochondrial autofluorescent coenzymes NADH (Nicotinamide Adenine Dinucleotide) and FAD (oxidized form of Flavin Adenine Dinucleotide (FADH2,)) as a measure of mitochondrial function in... Read more
Articles, Published Articles
Rapid, Affordable, and Point-of-Care Water Monitoring Via a Microfluidic DNA Sensor and a Mobile Interface for Global Health
Contaminated water is a serious concern in many developing countries with severe health consequences particularly for children. Current methods for monitoring waterborne pathogens are often time consuming, expensive, and labor intensive, making them not suitable for these regions. Electrochemical detection... Read more
Articles, Published Articles
Design and Characterization of an Osmotic Sensor for the Detection of Events Associated with Dehydration and Overhydration
The level of hydration in the human body is carefully adjusted to control the electrolyte balance that governs the biochemical processes that sustain life. An electrolyte deficiency caused by de- or overhydration will not only limit human performance, but can... Read more
Articles, Published Articles
Evaluating Innovative In-ear Pulse Oximetry for Unobtrusive Cardiovascular and Pulmonary Monitoring during Sleep
Homecare is healthcare based on the principle “outpatient before inpatient,” with the aim of moving at least some care-delivery to the home. But reliable determination of vital signs at home requires new, smart sensors, which can be used by the... Read more
Articles, Published Articles
Wireless Wearable Multisensory Suite and Real-Time Prediction of Sleep Apnea Episodes
Obstructive sleep apnea (OSA) is a common sleep disorder found in 24% of adult men and 9% of adult women. Although continuous positive airway pressure (CPAP) has emerged as a standard therapy for OSA, a majority of patients are not... Read more
Articles, Published Articles
Classroom to Clinic: Merging Education and Research to Efficiently Prototype Medical Devices
Innovation in patient care requires both clinical and technical skills, and this paper presents the methods and outcomes of a nine-year, clinical-academic collaboration to develop and evaluate new medical device technologies, while teaching mechanical engineering. Together, over the course of... Read more
Articles, Published Articles
Effects of the Alternate Combination of ‘Error-Enhancing’ and ‘Active Assistive’ Robot-Mediated Treatments on Stroke Patients
The present study aimed at investigating the effects of a novel robotic-aided rehabilitation treatment for the recovery of the upper limb related capabilities in chronic post stroke patients. Eighteen post-stroke patients were enrolled in a six weeks therapy program and... Read more
Articles, Published Articles
Refinement of the Facility-Level Medical Technology Score to Reflect Key Disease Response Capacity and Personnel Availability
This paper presents a second look at the computation of the Medical Technology Score (MTS), a metric designed to convey the relative technical competence of a health facility. Modification of the score to reflect local disease burden is discussed, as... Read more
Articles, Published Articles
A Non-Invasive Method for Estimating Cardiopulmonary Variables Using Breath-by-Breath Injection of Two Tracer Gases
Conventional methods for estimating cardiopulmonary variables usually require complex gas analysers and the active co-operation of the patient. Therefore, they are not compatible with the crowded environment of the Intensive Care Unit (ICU) or operating theatre, where patient co-operation is... Read more
Articles, Published Articles
Non-linear Dynamic Analysis of Inter-word Time Intervals in Psychotic Speech
“Language is a form and not a substance” Ferdinand de Saussure Objective: Analyses of speech processes in schizophrenia have been invariably focused on words as vocal signals. However, the results of such analyses are strongly related to content, and may be... Read more
Articles, Published Articles
Novel Tool for Complete Digitization of Paper Electrocardiography Data
Objective: We present a MATLAB-based tool to convert electrocardiography (ECG) information from paper charts into digital ECG signals. The tool can be used for long-term retrospective studies of cardiac patients to study evolving features with prognostic value. Methods and Procedures: To... Read more
Articles, Published Articles
Development of Novel Non-Contact Electrodes for a Mobile Electrocardiogram Monitoring System
Real-time monitoring of cardiac health is helpful for patients with cardiovascular disease. Many telemedicine systems based on ubiquitous computing and communication techniques have been proposed for monitoring the user’s electrocardiogram (ECG) anywhere and anytime. Usually, wet electrodes are used in... Read more
Articles, Published Articles
A Low Power Micro Deep Brain Stimulation Device for Murine Preclinical Research
Deep brain stimulation has emerged as an effective medical procedure that has therapeutic efficacy in a number of neuropsychiatric disorders. Preclinical research involving laboratory animals is being conducted to study the principles, mechanisms, and therapeutic effects of deep brain stimulation.... Read more
Articles, Published Articles
Vigorous Appraisal of Fluoride on Industrial Proponent in Thermal Power Plant over Anthropoid Biosphere Using F− Ion-Selective Electrode
This study was conducted to analyze the impact of fluoride in the anthropogenic condition in an industrial region promoting and affecting the health of the workers. Fluoride is toxic to humans in high concentrations, such as can occur in persons... Read more