BNM presents

Members

Chair

Thomas (Kin Fong) Lei, PhD
Professor, Graduate Institute of Biomedical Engineering Chang Gung University, Taoyuan, Taiwan

Laboratory: Bio-MEMS Lab
Email: kflei@mail.cgu.edu.tw
Tel: +886-3-2118800 ext. 5345 (Office), 5718 (Lab)

Research areas: Bio-microfluidics; MEMS; Bio-sensing; Cancer biology
His research interest is to develop Micro-ElectroMechanical Systems (MEMS) for bio-medical applications. They highlight the spirit of innovation and high quality up-stream research. Currently, they focus on three research topics: (a) Impedimetric monitoring of biological substances, i.e., cell, DNA, and protein, in microfluidic systems; (b) Paper-based microfluidics for cell-based assays; (c) Inhibition of cancer cell proliferation under electrical stimulation.

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Co-Chairs

Levent Yobas, PhD
Associate Professor, Department of Electronic and Computer Engineering, Department of Chemical and Biological Engineering, Hong Kong University of Science and Technology, Hong Kong

Email: eelyobas@ust.hk
Tel: +852-2358-7068

My research is mainly focused on silicon-based micro/nanofabrication and lab-on-a-chip micro/nanofluidic technologies for life sciences, drug discovery and point-of-care diagnostics. These technologies often use electrokinetic principles such as electrophoresis, dielectrophoresis, and electrohydrodynamics along with micro/nanostructures such as integrated nanocapillaries and non-planar microelectrodes. Current thrust areas of my research include biomedical microdevices for (a) cell manipulation, sorting, and treatment for the isolation and analysis of rare cells such as circulating tumor cells and (b) rapid biomacromolecule separation for on-chip analysis of proteins and nucleic acids.

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Hung-Wei Wu, PhD
Dean, College of CreaKve Media Director, InnovaKon Startup and IncubaKon Center Professor, Department of InformaKon and CommunicaKon Kun Shan University

Email: hwwu@mail.ksu.edu.tw

My research is including semiconductor, bioelectronics, and microwave engineering. In the field of bioelectronics, we proposed a high-efficiency circulating tumor cells screening biochip using the nanocrystalline silicon (nc-Si:H) thin film prepared by 40.68-MHz very high-frequency plasma-enhanced
chemical vapor deposition (VHFPECVD) and the very high-frequency atomic layer
deposition (VHFALD). The quality, uniformity, interface, and electrical properties of the
prepared nc-Si:H thin films affect the performance parameters of the biochip, such as
its recovery rate, purity, and survival rate, for screening circulating tumor cells. The
screening performance of the biochip is highly associated with the quality of the
deposited nc-Si:H thin films; therefore, an appropriate deposition technique is crucial for
applications in a clinical trial.

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Jie Chen, PhD
Professor of Electrical and Computer Engineering Department, Adjunct Professor of Biomedical Engineering Department, University of Alberta, Canada

Email: jc65@ualberta.ca
Tel: (780) 492-9820

Dr. Chen’s interdisciplinary research areas include: (a) MEMS/NMES-based Microfluidic Biosensors: Designing portable impedance-based and colorimetric point-of-care biosensors for detecting genomic/proteomic/metabolic biomarkers in bodily fluids (urine, blood, etc.). (b) Biomedical and Healthcare Devices: Developing a low-intensity pulsed-ultrasound technology platform to stimulate cell growth (with applications in cell therapy, tissue engineering, mental health, and antibody production), as well as microorganism growth (with applications in enhancing sludge activities for wastewater treatment, increasing renewable biofuel/algal oil, antibiotics, omega-3, and wine/beverage production). (c) VLSI and Low-Power Circuits: Designing low-power fault-tolerant nanoscale devices and circuits based on probabilistic Markov Random Field theory.

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Advisory Board

Colin Brenan, PhD
Founder and Chief Commercial Officer of HiFiBiO Ltd

colin.j.brenan@ieee.org

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Elsa Angelini, PhD
Faculty of Medicine, Department of Metabolism, Digestion and Reproduction Senior Data Scientist Imperial College London

e.angelini@imperial.ac.uk

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Members

Abhishek Dutta
Assistant Professor University of Connecticut, USA

Office: ITE 347
Phone: (860) 486-2210
Email: abhishek.dutta@uconn.edu

Dr. Dutta is an Assistant Professor at University of Connecticut with sustained international recognition in cybernetics, control and robotics, neural and biomedical engineering. Dr. Dutta has concurrent appointments in Electrical and Computer Engineering, the United Technologies Corporation - Institute for Advanced Systems Engineering, Biomedical Engineering in the School of Engineering and the Connecticut Institute for the Brain and Cognitive Sciences.

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Ali Khademhosseini
Harvard University, USA
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Amy Herr
UC Berkeley, USA
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Bonggeun Chung
Sogang University, South Korea
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Carmelina Ruggiero
University of Genova, Italy
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Catherine Picart
l’INP-PHELMA de Grenoble, France
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Christopher J. Bettinger
Professor, Biomedical Engineering, Materials Science and Engineering Carnegie Mellon University

The mission of the Bettinger Group at CMU is to design, synthesize, and process synthetic polymers into medical devices for use in neurotechnology. We leverage expertise in polymeric biomaterials and flexible electronics for use in next-generation medical devices that can integrate seamlessly with excitable tissue in the human body.

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Dean Ho
UCLA, USA
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Deok-Ho Kim
Associate Professor Departments of Biomedical Engineering and Medicine The Johns Hopkins University School of Medicine

Rm. 724B, Ross Research Building
720 Rutland Avenue
Baltimore, MD 21205
(410) 502-9773
Email: dhkim@jhu.edu

Dr. Kim’s research focuses on development of micro/nano-fabricated platforms for drug efficacy/toxicity screening and microphysiological models of inherited cardiomyopathy and peripheral neuropathy. Using micro/nano-fabricated tools in combination with human pluripotent stem cell technologies, his laboratory also seeks to gain a better understanding of disease biology and contribute to biotherapeutic development.

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Dino DiCarlo
PROFESSOR/VICE CHAIR GRADEDUCATION BIOENGINEERING MECHANICAL AND AEROSPACE ENGINEERING BE Department Vice Chair of Graduate Studies 5121E Engineering V

Email: dicarlo@seas.ucla.edu
Phone: (310) 983-3235
Fax: (310) 794-5956

Microfluidics and quantum assays. The Di Carlo Lab leverages microfluidics, microfabrication, and nanotechnologies to develop interfaces with cells and molecules for applications in disease diagnosis, therapeutic discovery, tissue regeneration, and directed evolution. These tools not only excel at the manipulation and analysis of single cells and molecules, but also are cost-effective and easily accessible -- thus democratizing advanced biotechnology capabilities to solve medical problems. Dr. Di Carlo’s innovations have led to further development in a number of startups, often led by students who initially were involved in projects in his lab. These startups are developing diagnostics, therapeutics, and life science research tools, and many are being commercially used.

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Eun Ji Chung
University of Southern California, USA
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Esmaiel Jabbari
Professor, Dept. of Chemical Engineering, Biomedical Engineering College of Engineering and Computing University of South Carolina

Email: jabbari@engr.sc.edu
Tel: 803-777-8022

Prof. Jabbari’s research thrusts include the fundamental and practical aspects in the development of novel medical implants for growth factor and stem cell delivery in regenerative medicine and cancer therapy. His research exploits biomimetic principles and micro/nano-scale technologies to develop multi-cellular tissue models to understand the effect of microenvironment on tissue organization and maintenance.

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Eyad Hamad
German Jordian University, Jordan
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Fariba Dehghani
University of Sydney, Australia
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Franz Baudenbacher
Vanderbilt University, USA
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Helen H. Lu
Columbia University, USA
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Hojae Bae
Konkuk University, South Korea
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Hongkai Wu
Hong Kong University of Science and Technology, Hong Kong
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Hung-Wei Wu
Dean, College of CreaKve Media Director, InnovaKon Startup and IncubaKon Center Professor, Department of InformaKon and CommunicaKon Kun Shan University

Email: hwwu@mail.ksu.edu.tw

My research is including semiconductor, bioelectronics, and microwave engineering. In the field of bioelectronics, we proposed a high-efficiency circulating tumor cells screening biochip using the nanocrystalline silicon (nc-Si:H) thin film prepared by 40.68-MHz very high-frequency plasma-enhanced
chemical vapor deposition (VHFPECVD) and the very high-frequency atomic layer
deposition (VHFALD). The quality, uniformity, interface, and electrical properties of the
prepared nc-Si:H thin films affect the performance parameters of the biochip, such as
its recovery rate, purity, and survival rate, for screening circulating tumor cells. The
screening performance of the biochip is highly associated with the quality of the
deposited nc-Si:H thin films; therefore, an appropriate deposition technique is crucial for
applications in a clinical trial.

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Hyowon (Hugh) Lee
Assistant Professor of Biomedical Engineering, Purdue University, USA

E-mail: hwlee@purdue.edu
Phone: +1 765 49-624444

Group Page
My research interest centers around improving the reliability and functionality of implantable medical devices using micro and nanoscale transducers. Examples of his research topics include implantable magnetic microactuators, neurostimulation electrodes, and various chronically implantable biochemical sensors. He is a recipient of NSF CAREER award and his lab is currently supported by NIH, NSF, Indiana Clinical and Translational Science Institute, Samsung, and Eli Lilly.

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Jeffrey Borenstein
Draper Laboratory

Email: jborenstein@draper.com

Jeffrey T. Borenstein is Group Leader of Synthetic Biology and Bio Instrumentation at Draper, where he leads a research program in the application of microfluidics technologies toward therapeutic devices and tools for drug development. His research focuses on next generation organ assist devices and implantable drug delivery systems for critical care, and on microfluidic organ models for cancer and other diseases.

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Jenny Emneus
DTU, Denmark
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Jianjun Cheng
UIUC, USA
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Jie Chen
Professor of Electrical and Computer Engineering Department, Adjunct Professor of Biomedical Engineering Department, University of Alberta, Canada

Email: jc65@ualberta.ca
Tel: (780) 492-9820

Dr. Chen’s interdisciplinary research areas include: (a) MEMS/NMES-based Microfluidic Biosensors: Designing portable impedance-based and colorimetric point-of-care biosensors for detecting genomic/proteomic/metabolic biomarkers in bodily fluids (urine, blood, etc.). (b) Biomedical and Healthcare Devices: Developing a low-intensity pulsed-ultrasound technology platform to stimulate cell growth (with applications in cell therapy, tissue engineering, mental health, and antibody production), as well as microorganism growth (with applications in enhancing sludge activities for wastewater treatment, increasing renewable biofuel/algal oil, antibiotics, omega-3, and wine/beverage production). (c) VLSI and Low-Power Circuits: Designing low-power fault-tolerant nanoscale devices and circuits based on probabilistic Markov Random Field theory.

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Joel Voldman
Professor & Faculty Head, Electrical Engineering Department of Electrical Engineering and Computer Science MIT, USA

Room 38-435
Cambridge, MA 02139
Ph: 617.253.2094

Prof. Voldman’s research focuses on leveraging microscale phenomena to impact biology and medicine.
His lab has developed a number of different approaches for manipulaPng and culturing cells in
microfluidic environments and measuring molecules using electronic immunoassays. He focuses focus on
systems that provide exquisite control over fluids and cells in order to exert control or make precise and
accurate measurements.

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Junji Fukuda
Division of Materials Science and Engineering, Faculty of Engineering Chemical Engineering and Life Science, Colledge of Engineering Science

Office: Room 517 in N8-5 Building Lab: Room 516, 511 in N8-5 Building
e-mail: fukuda@ynu.ac.jp
Tel: +81-45-339-4008
Contact information
Faculty of Engineering, Yokohama National University 79-5 Tokiwadai, Hodogaya-ku, Yokohama 240-8501 JAPAN

Prof. Junji Fukuda is a professor of the Faculty of Engineering, Yokohama National University, Japan. He is also an Adjunct Project Leader, KISTEC, Japan and an Associate Investigator, University of Wollongong, Australia. He obtained his master and Ph.D in Chemical Engineering from Kyushu University, Japan. His research area has been in the synthesis, processing, and evaluation of biomaterials for tissue engineering and regenerative medicine.

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Kihun Jeong
Kaist, Korea
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Thomas (Kin Fong) Lei
Professor, Graduate Institute of Biomedical Engineering Chang Gung University, Taoyuan, Taiwan

Laboratory: Bio-MEMS Lab
Email: kflei@mail.cgu.edu.tw
Tel: +886-3-2118800 ext. 5345 (Office), 5718 (Lab)

Research areas: Bio-microfluidics; MEMS; Bio-sensing; Cancer biology
His research interest is to develop Micro-ElectroMechanical Systems (MEMS) for bio-medical applications. They highlight the spirit of innovation and high quality up-stream research. Currently, they focus on three research topics: (a) Impedimetric monitoring of biological substances, i.e., cell, DNA, and protein, in microfluidic systems; (b) Paper-based microfluidics for cell-based assays; (c) Inhibition of cancer cell proliferation under electrical stimulation.

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Maryam Tabrizian
Professor Department of Biomedical Engineering Associate Dean Research and Graduate Studies, Faculty of Dentistry McGill University

Email: maryam.tabrizian@mcgill.ca

Maryam Tabrizian’s research aim at developing hybrid and functional biomaterials and biointerfaces for their applications in regenerative medicine, nanomedicine, immunomodulation and diagnostic tools. This implies the development of biomimetic and 3-D hydrogels, nanocoating on both artificial and biological templates, high throughput synthesis of nanoparticles, and microfluidic lab-on-a chip device.

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Manasi Madhav Raje
TL Biolabs, Santa Clara, CA
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Matthias Lutolf
EPFL, Switzerland
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Mehmet Remzi Dokmeci
Associate Adjunct Professor Radiology Department at University of California-Los Angeles

Email: mdokmeci@mednet.ucla.edu

Dr. Dokmeci has a strong background in designing and fabricating micro- and nano sensors, biomaterials, tissue engineering, implantable devices and encapsulation technologies and biomedical microsystems. He is interested in flexible electronics for monitoring and modulation of wound healing, electrical/electrochemical biosensors and microfluidic systems for organs-on-a-chip applications and 3D bioprinting.

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Michael Pycraft Hughes
Professor University of Surrey, UK

Guildford, Surrey GU2 7XH, UK (+44) 1483 686775

Dielectrophoresis of cells and nanoparticles, divided between instrumentation development (such as cell
characterization and separation tools, now spun out and commercially available) and fundamental study of the electrical properties of cells. These are used to develop new approaches to understanding cell behaviour, and diagnosing and treating disease.

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Milica Radisic
Professor (BME, ChemE) Department of Chemical Engineering & Applied Chemistry University of Toronto

Tel.: 416-946-5295
Email: m.radisic@utoronto.ca

Her research is focused on developing heart-on-a-chip based screening technologies using iPSC that can
facilitate a paradigm shiR to a personalized medicine approach with pre-evaluaUon of agents for safety and efficacy ex vivo, using a paUent’s own normal and diseased Ussues. She is also focused on overcome manufacturing challenges fueling adopUon of these devices and understand the mechanisms at play through genomic and proteomic screens.

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Levent Yobas
Associate Professor, Department of Electronic and Computer Engineering, Department of Chemical and Biological Engineering, Hong Kong University of Science and Technology, Hong Kong

Email: eelyobas@ust.hk
Tel: +852-2358-7068

My research is mainly focused on silicon-based micro/nanofabrication and lab-on-a-chip micro/nanofluidic technologies for life sciences, drug discovery and point-of-care diagnostics. These technologies often use electrokinetic principles such as electrophoresis, dielectrophoresis, and electrohydrodynamics along with micro/nanostructures such as integrated nanocapillaries and non-planar microelectrodes. Current thrust areas of my research include biomedical microdevices for (a) cell manipulation, sorting, and treatment for the isolation and analysis of rare cells such as circulating tumor cells and (b) rapid biomacromolecule separation for on-chip analysis of proteins and nucleic acids.

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Michelle Khine
UC Irvine, USA
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Molly M. Stevens
Imperial College, UK
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Pei-Yu (Eric) Chiou
UCLA, USA
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Rashid Bashir
UIUC, USA
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Samuel Sia
University of Columbia, USA
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SangHoon Lee
University of Korea, Korea
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Shaochen Chen
Professor and Chair of NanoEngineering Department Professor of Bioengineering Department Founding Co-Director of Biomaterials and Tissue Engineering Center University of California, San Diego

Tel: (858) 822-7856

Dr. Chen is a pioneer in 3D prinUng and bioprinUng. He has published over 150 journal publicaUons. His research interests include: 3D Printing and Bioprinting, Stem Cells and Tissue Engineering, Biomaterials and Nanomaterials, and Organ/Tissueon-a-Chip.

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Shirley Tang
Waterloo University, Canada
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Shuichi Takayama
University of Michigan, USA
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Steve C. C. Shih
Assistant Professor, Concordia University Dept. of Electrical and Computer Engineering (EV 16.189) Dept. of Biology (cross-appointed) (GE 330.15) Center for Applied Synthetic Biology (CASB)

Tel: 514 848 2424 x7579

The Shih lab is focused on an inter-disciplinary approach of combining engineering, biology, and chemistry to solve novel problems in these fields. Specifically, his group is using droplet-based microfluidic platforms for automating processes in mammalian gene-editing, synthetic biology, directed evolution, and biosensor development. By automating these processes his group can quickly develop novel organisms that can be used to produce renewable sources of fuel and new cellular therapies for eradicating diseases.

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Sumita Pennathur
UC Santa Barbara, USA
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Utkan Demirci
Harvard University, USA
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Xingyu (Justin) Jiang
Chinese Academy of Sciences, China
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Yanan Du
Tsinghua University, China
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Yunzhi Yang
Associate Professor Departments of Orthopedic Surgery, (by courtesy) Materials Science and Engineering, and Bioengineering Co-director of Medical Scholar Program in Bioengineering Scholarly Concentration Member, Bio-X Member, Maternal & Child Health Research Institute Faculty Fellow, Stanford ChEM-H Faculty Fellow, Wu Tsai Neurosciences Institute Stanford University

T: 650-723-0772 (Office)
650-725-8698 (Lab)
F: 650-721-5404
Email: ypyang@stanford.edu

Biomaterials, medical devices, stem cells and bioprinting for musculoskeletal tissue engineering

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