In this paper, the design of a smart headband for epileptic seizure detection is presented. The proposed headband consists of four key components: 1) an analog front-end circuitry, 2) an epileptic seizure detection tag (ESDT), 3) a Bluetooth Low Power (BLE) chip, and 4) customized electrodes. All the above components are integrated into a fabric headband with only 50.3 g. The smart headband system dissipates 55.89 mW. The epileptic seizure detection algorithm inside ESDT is validated by using Boston Children’s Hospital’s CHB-MIT scalp EEG clinical database with the detection rate of 92.68% and the false alarm of 0.527/hour. We develop a service APP connected to the cloud so that the patients’ health condition can be recorded and then referenced by doctors for further diagnosis or research.