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Featured Articles
Temozolomide in Combination With NF-κB Inhibitor Significantly Disrupts the Glioblastoma Multiforme Spheroid Formation
Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor, accounting for 50% of all cases. GBM patients have a five-year survival rate of merely 5.6% and a median overall survival of 14.6 months with the “Stupp” regimen, 20.9... Read more
Featured Articles
Accelerometry-Based Digital Gait Characteristics for Classification of Parkinson’s Disease: What Counts?
Gait may be a useful biomarker that can be objectively measured with wearable technology to classify Parkinson’s disease (PD). This study aims to: (i) comprehensively quantify a battery of commonly utilized gait digital characteristics (spatiotemporal and signal-based), and (ii) identify... Read more
Articles
Neural Implants Without Electronics: A Proof-of-Concept Study on a Human Skin Model
Objective: Chronic neural implants require energy and signal supply. The objective of this work was to evaluate a multichannel transcutaneous coupling approach in an ex vivo split-concept study, which minimizes the invasiveness of such an implant by externalizing the processing... Read more
Articles
Plasmin cascade mediates thrombotic events in SARS-CoV-2 infection via complement and platelet-activating systems
Recently emerged beta-coronavirus SARS-CoV-2, has resulted in the current pandemic designated COVID-19. COVID-19 manifests as severe illness exhibiting systemic inflammatory response syndrome, acute respiratory distress syndrome (ARDS), thrombotic events, and shock, exacerbated further by co-morbidities and age. Recent clinical evidence... Read more
Featured Articles
Lung Nodule Malignancy Prediction from Longitudinal CT Scans with Siamese Convolutional Attention Networks
Goal: We propose a convolutional attention-based network that allows for use of pre-trained 2-D convolutional feature extractors and is extendable to multi-time-point classification in a Siamese structure. Methods: Our proposed framework is evaluated for single- and multi-time-point classification to explore... Read more