Stephen T. Wong

Title and Affiliation

John S. Dunn Sr. Presidential Distinguished Chair of Biomedical Engineering & Department Chair
Department of Systems Medicine and Bioengineering
Houston Methodist Research Institute

Director of Translational Research
Methodist Cancer Center

Professor of Radiology, Neuroscience, Pathology and Laboratory Medicine
Departments of Radiology, Pathology, and Neurology
Weill Cornell Medical College
Cornell University

Chief Research Information Officer and Chief of Medical Physics
Houston Methodist Hospital
Houston Neurological Institute

Web Page

Stephen T. Wong


Phone: 713-441-5883
Address: 6670 Bertner MC: R6-414, Houston, TX 77030, USA

Research Interests

Biomedical and Health Informatics (e.g. gene sequencing analysis, imaging informatics, mobile health informatics, etc.) for Precision Medicine

Big Data Approaches for Drug Repositioning and Disease Management

Dynamic Systems Modeling for Prediction (e.g. molecular pathway dynamics, cellular/tissue dynamics, whole body physiological dynamics)

Label-free Molecular and Chemical Imaging for Diagnosis and Therapy

Image-guided Intervention

Stem Cell Medicine and Neuroregeneration


Dr. Wong’s research focuses on understanding health and disease from a systems perspective in order to generate cost-effective strategies and solutions for disease management. His research approaches combine both experimental and high throughput biology with rigorous computational, bioinformatics, biophysics, and imaging methods to achieve a deep understanding of the functions of each component in biological systems and integrated them with multilevel systems analysis. For example, the consequences of genetic variation, cell-cell interactions, and environmental factors are included to reflect the circumstances and microenvironments of the disease condition. Current research projects include pathway modeling and high throughput phenotyping approaches for target discovery and drug repurposing in combating neurological disorders and cancer and for understanding the mechanisms of these diseases, reformulation of small molecule drugs using chemical biology approaches, the development of point-of-care molecular diagnosis and monitoring devices using biophotonics and nanotechnology techniques, and the development of label-free molecular image-guided cancer therapy platforms.

Lab Page

The Methodist Hospital Research Institute

Selected Journal Publications

Pathak P, Zhao H, Gong Z, Nie F, Zhang T, Cui K, Wang Z, Wong ST, Que L: Real-time monitoring of cell viability using direct electrical measurement with a patch-clamp microchip. Biomedical Microdevices 2011:1-5

Jin G, Zhao H, Zhou X, Wong ST: An enhanced Petri-net model to predict synergistic effects of pairwise drug combinations from gene microarray data. Bioinformatics 2011, 27(13):i310

Wang Z, Gao L, Luo P, Yang Y, Hammoudi AA, Wong KK, Wong ST. t anti-Stokes Raman scattering microscopy imaging with suppression of four-wave mixing in optical fibers. Opt Express. 2011 Apr 25;19(9):7960-70

Hu X, Wong KK, Young GS, Guo L, Wong ST. Support vector machine multiparametric MRI identification of pseudoprogression from tumor recurrence in patients with resected glioblastoma. J Magn Reson Imaging. 2011 Feb;33(2):296-305

Huang D, Zhou X, Lyon CJ, Hsueh WA, Wong ST. MicroRNA-integrated and network-embedded gene selection with diffusion distance. PLoS One. 2010 Oct 29;5(10):e13748

Xia X, Yang J, Li F, Li Y, Zhou X, Dai Y, Wong ST. Image-based chemical screening identifies drug efflux inhibitors in lung cancer cells. Cancer Res. 2010 Oct 1;70(19):7723-33

Wan M, Luo PF, Jin JY, Xing J, Wang Z, Wong ST. Fabrication of localized surface plasmon resonance fiber probes using ionic self-assembled gold nanoparticles. Sensors. 10:6477-6487 (2010)

Selected Conference Publications

Yang Y, Gao L, Wang Z, Thrall MJ, Luo P, Wong KK, Wong ST: Label-free imaging of human breast tissues using coherent anti-Stokes Raman scattering microscopy. In: SPIE: 2011. 79032G

Mao Y, Cui K, Lulu W, Zhao H, Nie F, Brandl M, Beck D, Gao L, Wong ST. Drug reposition for tumor anti-migration – a systemic in-silico approach. LiSSA, Bethesda, MD, April 7-8, 2011

Z. Xue, H. Li, T.M. Ellmore, B. Malmberg, R.E. Frye, S.T. Wong. Anatomical Connectivity-Based Analysis of Autism Using Diffusion Tensor Imaging. 10th International Meeting for Autism Research, May 2011

Chen K, Zhang Y, Pohl K, Syeda-Mahmood T, Song Z, Wong ST. Coronary artery segmentation using geometric moments based tracking and snake-driven refinement. Conf Proc IEEE Eng Med Biol Soc. 2010;1:3133-7

Taoyi Chen, Zhong Xue, Changhong Wang, Zhenshen Qu, Kelvin K. Wong, Wong ST. Motion Artifact Correction of Multi-Photon Imaging of Awake Mice Models Using Speed Embedded HMM, MICCAI, LNCS 6363, Beijing, Sept 2010

Srinivasan R, Li Q, Zhou X, Lu J, Lichtman J, Wong ST. Reconstruction of the Neuromuscular Junction Connectome, 18th Annual International Conference on Intelligent Systems for Molecular Biology – Conference (ISMB), Boston, July 10-14, 2010