Featured Articles

Optimal Control Perspective on Parkinson’s Disease: Increased Delay Between State Estimator and Controller Produces Tremor
Author(s)3: Christopher R. Kelley, Jeffrey L. Kauffman
Optimal Control Perspective on Parkinson’s Disease: Increased Delay Between State Estimator and Controller Produces Tremor 770 1000 Transactions on Neural Systems and Rehabilitation Engineering (TNSRE)
Parkinson’s disease produces tremor in a large subset of patients despite generally inhibiting movement. The pathophysiology of parkinsonian tremor is unclear, leading to uncertainty in how and why treatments reduce tremor with varying effectiveness. Models for parkinsonian tremor attempt to explain the underlying principles of tremor generation in the central nervous system, often focusing on neural activity of specific substructures. read more

Topological Network Analysis of Early Alzheimer’s Disease Based on Resting-State EEG
Author(s)3: Feng Duan, Zihao Huang, Zhe Sun, Yu Zhang, Qibin Zhao, Andrzej Cichocki, Zhenglu Yang, Jordi Solé-Casals
Topological Network Analysis of Early Alzheimer’s Disease Based on Resting-State EEG 1000 370 Transactions on Neural Systems and Rehabilitation Engineering (TNSRE)
Previous studies made progress in the early diagnosis of Alzheimer’s disease (AD) using electroencephalography (EEG) without considering EEG connectivity. To fill this gap, we explored significant differences between early AD patients and controls based on frequency domain and spatial properties using functional connectivity in mild cognitive impairment (MCI) and mild AD datasets. read more

Toward Predicting Infant Developmental Outcomes from Day-Long Inertial Motion Recordings
Author(s)3: Naomi T. Fitter, Rebecca Funke, José Carlos Pulido, Maja J. Matarić, Beth A. Smith
Toward Predicting Infant Developmental Outcomes from Day-Long Inertial Motion Recordings 1000 964 Transactions on Neural Systems and Rehabilitation Engineering (TNSRE)
As improvements in medicine lower infant mortality rates, more infants with neuromotor challenges survive past birth. The motor, social, and cognitive development of these infants are closely interrelated, and challenges in any of these areas can lead to developmental differences. read more

Dynamic Bayesian Adjustment of Dwell Time for Faster Eye Typing
Author(s)3: Jimin Pi, Paul A. Koljonen, Yong Hu, Bertram E. Shi
Dynamic Bayesian Adjustment of Dwell Time for Faster Eye Typing 1000 733 Transactions on Neural Systems and Rehabilitation Engineering (TNSRE)
Eye typing is a hands-free method of human computer interaction, which is especially useful for people with upper limb disabilities. Users select a desired key by gazing at it in an image of a keyboard for a fixed dwell time. There is a tradeoff in selecting the dwell time; shorter dwell times lead to errors due to unintentional selections, while longer dwell times lead to a slow input speed. read more

Should Hands Be Restricted When Measuring Able-Bodied Participants to Evaluate Machine Learning Controlled Prosthetic Hands?
Author(s)3: Morten B. Kristoffersen, Andreas W. Franzke, Corry K. van der Sluis, Raoul M. Bongers, Alessio Murgia
Should Hands Be Restricted When Measuring Able-Bodied Participants to Evaluate Machine Learning Controlled Prosthetic Hands? 786 1000 Transactions on Neural Systems and Rehabilitation Engineering (TNSRE)
When evaluating methods for machine-learning controlled prosthetic hands, able-bodied participants are often recruited, for practical reasons, instead of participants with upper limb absence (ULA). However, able-bodied participants have been shown to often perform myoelectric control tasks better than participants with ULA. read more

Modeling of Human Operator Behavior for Brain-Actuated Mobile Robots Steering
Author(s)3: Hongqi Li, Luzheng Bi, Haonan Shi
Modeling of Human Operator Behavior for Brain-Actuated Mobile Robots Steering 1000 709 Transactions on Neural Systems and Rehabilitation Engineering (TNSRE)
Human operator control of brain-actuated robot steering based on electroencephalograph (EEG)-signals is a complex behavior consisting of surroundings perceiving, decision making, and commands issuing and differs among individual operators. read more

A Backpack Minimizing the Vertical Acceleration of the Load Improves the Economy of Human Walking
Author(s)3: Lei He, Caihua Xiong, Qinhao Zhang, Wenbin Chen, Chenglong Fu, Kok-Meng Lee
A Backpack Minimizing the Vertical Acceleration of the Load Improves the Economy of Human Walking 799 1000 Transactions on Neural Systems and Rehabilitation Engineering (TNSRE)
Loaded walking with a rucksack results in both gravitational and inertial forces of the load that must be borne by human carriers. The inertial force may be the source of metabolic burden and musculoskeletal injuries. This paper presents a lightweight backpack with a disturbance observer-based acceleration control to minimize the inertial force. read more

Test-Retest Reliability of Kinematic Assessments for Upper Limb Robotic Rehabilitation
Author(s)3: T. Koeppel, O. Pila
Test-Retest Reliability of Kinematic Assessments for Upper Limb Robotic Rehabilitation 1000 359 Transactions on Neural Systems and Rehabilitation Engineering (TNSRE)
Robot-measured kinematic variables are increasingly used in neurorehabilitation to characterize motor recovery following stroke. However, few studies have evaluated the reliability of these kinematic variables. This study aimed at evaluating the test-retest reliability of typically-used robot-measured kinematic variables in healthy subjects (HS) and patients with stroke (SP). read more

Actuation selection for assistive exoskeletons: matching capabilities to task requirements
Author(s)3: Andrea Calanca, Stefano Toxiri, Davide Costanzi, Enrico Sartori, Rudy Vicario, Tommaso Poliero, Christian Di Natali, Darwin G. Caldwell, Paolo Fiorini, Jesus Ortiz
Actuation selection for assistive exoskeletons: matching capabilities to task requirements 940 1000 Transactions on Neural Systems and Rehabilitation Engineering (TNSRE)
Selecting actuators for assistive exoskeletons involves decisions in which designers usually face contrasting requirements. While certain choices may depend on the application context or design philosophy, it is generally desirable to avoid oversizing actuators in order to obtain more lightweight and transparent systems, ultimately promoting the adoption of a given device. read more

A Framework of a Lower Limb Musculoskeletal Model With Implemented Natural Proprioceptive Feedback and Its Progressive Evaluation
Author(s)3: Haotian Zhang, Fuhao Mo, Lizhen Wang, Michel Behr, Pierre-Jean Arnoux
A Framework of a Lower Limb Musculoskeletal Model With Implemented Natural Proprioceptive Feedback and Its Progressive Evaluation 814 716 Transactions on Neural Systems and Rehabilitation Engineering (TNSRE)
Proprioceptive senses play an important role in human body reflex and movement, so far implementing physiological mathematical models of proprioceptors in the musculoskeletal model and investigating their effects have not been sufficiently investigated. read more

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TNSRE serves the community of biomedical engineers and clinical researchers who work at the intersection of neuroscience and physical medicine. We publish novel approaches and technologies for better understanding neural systems, human movement, and the relationships between them, with a focus on assistive devices that improve life for patients, for practicing clinicians, and for everyday use.

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