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Intravenously Administered gamma-Ferric Oxide Particle Amount Measured Using Vibrating Sample Magnetometer

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Abstract

Dispersions of platelet gamma-ferric oxide particles 30–50nm in size were intravenously administered to mice and the amount of particles accumulated in each tissue was obtained by magnetization measurement using a vibrating sample magnetometer. Background noise was greatly reduced by measuring dried tissues under a magnetic field of 500 Oe so that the effect of diamagnetism was slight. Remarkable particle accumulation was observed in the liver and spleen. Considerable particle accumulation was observed in the lung when a large quantity of gamma-ferric oxide particles was administered. There was no significant particle accumulation in the kidney and heart.

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