IEEE Transactions on Biomedical Engineering
TBME 60th Anniversary

TBME 60th Anniversary
Magnetic Resonance Imaging at Ultrahigh Fields
Kamil Uğurbil, University of Minnesota, Volume 61, Issue 5, page: 1364-1379 The last two decades have witnessed revolutionary changes in our ability to study biological processes in the human body, in particular the human brain.  Magnetic resonance Imaging (MRI) and spectroscopy at... Read more
TBME 60th Anniversary
Small-Animal Whole-Body Photoacoustic Tomography: A Review
Jun Xia, Lihong V. Wang, Optical Imaging Lab, Washington University in St. Louis Volume 61, Issue 5, Page:1380-1389 Small animals, especially mice, are widely used in biomedical research for studying and modeling the progression of human diseases and the response to potential therapies.... Read more
TBME 60th Anniversary
Electrical Tissue Property Imaging at Low Frequency Using MREIT
Jin Keun Seo and Eung Je Woo, Yonsei University & Kyung Hee University, Open Access, Volume 61, Issue 5, Page:1390-1399  The tomographic imaging of tissue’s electrical properties (e.g., conductivity and permittivity) has been greatly improved by recent developments in magnetic resonance (MR) imaging techniques,... Read more
TBME 60th Anniversary
Breast Cancer Histopathology Image Analysis: A Review
Mitko Veta, Josien P.W. Pluim, Paul J. van Diest, and Max A. Viergever University Medical Center Utrecht, Utrecht, The Netherlands, Volume 61, Issue 5, Page: 1400-1411 Pathology labs are currently undergoing a transformation towards a fully digital workflow. In addition to the... Read more
TBME 60th Anniversary
Retinal Prosthesis
James D. Weiland and Mark S. Humayun, University of Southern California, Volume 61, Issue 5, page: 2629-2641 Retinal prostheses have been translated from the laboratory to the clinic over the past two decades. Currently, two devices have regulatory approval for the treatment... Read more
TBME 60th Anniversary
Brain-Computer Interfaces Using Sensorimotor Rhythms: Current State and Future Perspectives
Han Yuan, Bin He Laureate Institute for Brain Research, Tulsa, Oklahoma, USA; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA, Volume 61, Issue 5, Page: 1425 – 1435                           ... Read more
TBME 60th Anniversary
Visual and Auditory Brain-Computer Interfaces
Shangkai Gao, Yijun Wang, Xiaorong Gao, Bo Hong Tsinghua University, University of California San Diego, Volume 61, Issue 5, Page:1436-1447 Brain signal modulation in visual and auditory BCI systems. Over the past several decades, electroencephalogram (EEG)-based brain-computer interfaces (BCIs) have attracted attention from... Read more
TBME 60th Anniversary
The Past, Present, and Future of Real-Time Control in Cellular Electrophysiology
Jennifer A. Bauer, Katherine M. Lambert, and John A. White, Brain Institute, University of Utah Volume 61, Issue 5, Page:1448-1456 Control-based strategies have been critical for advancing our understanding of the mechanisms of electrical excitability in nerve and muscle cells.  For example, in... Read more
TBME 60th Anniversary
A Brief History of Tissue Models for Cardiac Electrophysiology
Craig S. Henriquez, Duke University, Volume 61, Issue 5, Page:1457-1465 The first biophysically based cardiac tissue model, combining equations for the cell-to-cell connections with a realistic representation of the membrane current fluxes, was developed nearly 45 years ago. In the decades that... Read more
TBME 60th Anniversary
A Shocking Past: A Walk Through Generations of Defibrillation Development
Sarah Gutbrod and Igor R. Efimov, Washington University in Saint Louis, Volume 61, Issue 5, Page:1466-1473 Defibrillation is one of the most successful and widely recognized applications of electrotherapy. It is the only available treatment of sudden cardiac death due to ventricular... Read more
TBME 60th Anniversary
Hydrogels as Carriers for Stem Cell Transplantation
Melissa Alvarado-Velez, S. Balakrishna Pai, and Ravi V. Bellamkonda Georgia Institute of Technology & Emory University, Volume 61, Issue 5, Page:1474-1481 Stem cell transplantation is a promising therapy for several degenerative conditions. However, a number of limitations such as low cell survival,... Read more
TBME 60th Anniversary
Strategies for Whole Lung Tissue Engineering
Elizabeth A. Calle, Mahboobe Ghaedi, Sumati Sundaram, Amogh Sivarapatna, Michelle K. Tseng, and Laura E. Niklason, Yale University, Volume 61, Issue 5, Page: 1482-1496 Whole organ engineering, including that of whole lungs, requires three central components: a scaffold, cells to populate... Read more
TBME 60th Anniversary
Recent Advances in Thermal Treatment Techniques and Thermally Induced Immune Responses Against Cancer
J. F. Bai, P. Liu, and L. X. Xu, Shanghai Jiao Tong University, Volume 61, Issue 5, Page:1497-1505 Thermal ablation techniques present promising approaches to tumor treatment because of its recent advances in precise energy delivery and real-time monitoring, its non- or... Read more
TBME 60th Anniversary
Toward Integrated Molecular Diagnostic System (iMDx): Principles and Applications
Seung-min Park, Andrew Sabour, Jun Ho Son, Sang Hun Lee, Luke Lee Stanford University & University of California, Berkeley, Volume 61, Issue 5, Page: 1506-1521 A new golden age in medicine will begin through the mass development of fully integrated, rapid, and remarkably accurate... Read more
TBME 60th Anniversary
Integrated Circuits and Electrode Interfaces for Noninvasive Physiological Monitoring
Sohmyung Ha, Chul Kim, Yu Mike Chi, Abraham Akinin, Christoph Maier, Akinori Ueno, Gert Cauwenberghs University of California San Diego, Cognionics Inc. & Tokyo Denki University, Volume 61, Issue 5, Page:1522-1537 Throughout the history of biomedical instrumentation, non-invasive techniques for physiological monitoring... Read more
TBME 60th Anniversary
Unobtrusive Sensing and Wearable Devices for Health Informatics
Ya-Li Zheng, Xiao-Rong Ding, Carmen Chung Yan Poon, Benny Ping Lai Lo, Heye Zhang, Xiao-Lin Zhou, Guang-Zhong Yang, Ni Zhao, Yuan-Ting Zhang, The Chinese University of Hong Kong, The Chinese Academy of Sciences (HICAS) at SIAT, Imperial College London, Volume 61, Issue 5,... Read more
Featured Articles, TBME 60th Anniversary
A Review of Multitaper Spectral Analysis
Behtash Babadi, Emery N. Brown, University of Maryland, Massachusetts Institute of Technology Volume 61, Issue 5, Page: 1555-1564 Non-parametric spectral estimation is widely used in applications ranging from radar and seismic data analysis to electroencephalography (EEG) and speech processing. The objective of non-parametric spectral... Read more
Featured Articles, TBME 60th Anniversary
From Passive Tool Holders to Microsurgeons: Safer, Smaller, Smarter Surgical Robots
Christos Bergeles, and Guang-Zhong Yang The Hamlyn Centre, Imperial College London, United Kingdom, Volume 61, Issue 5, Page: 1565-1576 Within only a few decades from its initial introduction, the field of surgical robotics has evolved into a dynamic and rapidly growing... Read more
Featured Articles, TBME 60th Anniversary
Advancing Our Understanding of the Glucose System via Modeling: A Perspective
C. Cobelli, C. Dalla Man, M. Pedersen, A. Bertoldo, G. Toffolo, University of Padova Volume 61, Issue 5, Page:1577-1592 The glucose story begins with Claude Bernard’s discovery of glycogen and milieu interieur, continued with Fredrick Banting’s and Charles Best’s discovery of insulin... Read more
Featured Articles, TBME 60th Anniversary
Dissecting Heart Failure Through the Multiscale Approach of Systems Medicine
Linda Pattini, Roberto Sassi, and Sergio Cerutti, Politecnico di Milano and Università degli Studi di Milano, Volume 61, Issue 5, Page: 1593-1603 Chronic Heart Failure is a complex syndrome, which can be the exit of different etiologies, consisting in the inability of... Read more