A factorial approach for optimizing the design parameters of a tissue attachment mechanism for drug delivery
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IEEE Transactions on Biomedical Engineering (TBME)
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In this work, a tissue attachment mechanism (TAM) was designed, optimized, and validated for a drug delivery ingestible capsule robot with a straightforward and mass-producible fabrication process. For the first time with this type of device, an optimization process was conducted on live tissue incorporating the dynamic nature of tissue response, and an attachment success rate of 92% was achieved. The duration test in a live and mobile large animal model showed a consistent and reliable attachment duration of over 30 hours, making the TAM a suitable candidate for a 24-hour long systemic drug delivery platform.
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