optical coherence tomography

Ultra-high-resolution 3D optical coherence tomography reveals inner structures of human placenta-derived trophoblast organoids

Author(s): Abigail Joyce Deloria, Sandra Haider, Bianca Dietrich, Victoria Kunihs, Simon Oberhofer, Martin Knofler, Rainer A. Leitgeb, Mengyang Liu, Wolfgang Drexler, Richard Haindl
Ultra-high-resolution 3D optical coherence tomography reveals inner structures of human placenta-derived trophoblast organoids 170 177 IEEE Transactions on Biomedical Engineering (TBME)
Many pregnancy complications are assumed to have their pathophysiological roots in early stages of placentation. Hence, trophoblast research represents a pre-requisite to help preventing pregnancy disorders that endangers uncomplicated gestations and jeopardizes maternal/fetal wellbeing later in life. Recently established 3D trophoblast organoids (TB-ORG) advanced human placental research. However, gold standard methods for determining TB-ORG architectures lack imaging depth and/or are endpoint analyses. We addressed these problems with 3D optical coherence tomography (OCT). This work demonstrates for the first time that OCT resolves label-free inner structures of TB-ORG during cultivation and enables qualitative/quantitative assessment of their differentiation status without sample destruction. read more

Optical Coherence Tomography Guided Robotic Needle Insertion for Deep Anterior Lamellar Keratoplasty

Author(s): Mark Draelos, Gao Tang, Brenton Keller, Anthony Kuo, Kris Hauser, Joseph A. Izatt
Optical Coherence Tomography Guided Robotic Needle Insertion for Deep Anterior Lamellar Keratoplasty 170 177 IEEE Transactions on Biomedical Engineering (TBME)
Deep anterior lamellar keratoplasty (DALK) is a promising form of partial-thickness cornea transplantation, but its popular “big bubble” technique frequently fails due to difficulty controlling a needle insertion into the cornea. We addressed the surgeon challenges that reduce success rates by demonstrating an optical coherence tomography (OCT)-guided, robotically stabilized workstation for manually or automatically performing DALK needle insertions. In a study with cornea fellows, we found that OCT visualization versus the standard stereo microscope was a key enabler in manual attempts and that our automatic robotic method met or exceeded the performance of cornea fellows. read more

Glaucoma progression detection using structural retinal nerve fiber layer measurements and functional visual field points

Glaucoma progression detection using structural retinal nerve fiber layer measurements and functional visual field points 556 235 IEEE Transactions on Biomedical Engineering (TBME)

Siamak Yousefi, Michael H. Goldbaum, Madhusudhanan Balasubramanian, Tzyy-Ping Jung, Robert N. Weinreb, Felipe A. Medeiros, Linda M. Zangwill, Jeffrey M. Liebmann, Christopher A. Girkin, and Christopher Bowd University of California San…

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