Imaging

Mechanical Imaging of Soft Tissues with Miniature Climbing robots

Author(s): Artem Dementyev, Rianna M Jitosho, Joseph A Paradiso
Mechanical Imaging of Soft Tissues with Miniature Climbing robots 170 176 IEEE Transactions on Biomedical Engineering (TBME)
We propose a method that uses our previously developed skin-crawling robots to noninvasively test the mechanical properties of soft tissue. We explore the use of two miniature sensors: an indenter and a cutometer. We evaluate the sensor’s performance from data collected on simulated tissue, classifying the depth and size of a simulated lump with over 98.8% accuracy using convolutional neural nets. Finally, we do limited on-body testing to map dry skin on the forearm with a cutometer. We hope to improve the ability to test tissues noninvasively, providing better sensitivity and systematic data collection. read more

Ultra-high-resolution 3D optical coherence tomography reveals inner structures of human placenta-derived trophoblast organoids

Author(s): Abigail Joyce Deloria, Sandra Haider, Bianca Dietrich, Victoria Kunihs, Simon Oberhofer, Martin Knofler, Rainer A. Leitgeb, Mengyang Liu, Wolfgang Drexler, Richard Haindl
Ultra-high-resolution 3D optical coherence tomography reveals inner structures of human placenta-derived trophoblast organoids 170 177 IEEE Transactions on Biomedical Engineering (TBME)
Many pregnancy complications are assumed to have their pathophysiological roots in early stages of placentation. Hence, trophoblast research represents a pre-requisite to help preventing pregnancy disorders that endangers uncomplicated gestations and jeopardizes maternal/fetal wellbeing later in life. Recently established 3D trophoblast organoids (TB-ORG) advanced human placental research. However, gold standard methods for determining TB-ORG architectures lack imaging depth and/or are endpoint analyses. We addressed these problems with 3D optical coherence tomography (OCT). This work demonstrates for the first time that OCT resolves label-free inner structures of TB-ORG during cultivation and enables qualitative/quantitative assessment of their differentiation status without sample destruction. read more

Spatially Coherent Activation Maps for Electrocardiographic Imaging

Author(s): Josselin Duchateau, Mark Potse, Remi Dubois
Spatially Coherent Activation Maps for Electrocardiographic Imaging 170 177 IEEE Transactions on Biomedical Engineering (TBME)

Electrocardiographic imaging (ECGi) is an emerging non-invasive technique that computes unipolar electrograms (EGMs) at the epicardial surface from high-density body-surface ECG recordings and torso anatomy. Activation mapping is an important…

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A Biocompatible Near-Infrared 3D Tracking System

Author(s): Ryan S. Decker, Azad Shademan, Justin D. Opfermann, Simon Leonard, Peter C. W. Kim, Axel Krieger
A Biocompatible Near-Infrared 3D Tracking System 127 132 IEEE Transactions on Biomedical Engineering (TBME)

A fundamental challenge in soft-tissue surgery is that target tissue moves and deforms, becomes occluded by blood or other tissue, and is difficult to differentiate from surrounding tissue. To overcome…

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