HSP27

Millimeter-wave heating in vitro: local microscale temperature measurements correlated to heat shock cellular response

Author(s): Rosa Orlacchio, Denys Nikolayev, Yann Le Page, Yves Le Dréan, Maxim Zhadobov
Millimeter-wave heating in vitro: local microscale temperature measurements correlated to heat shock cellular response 170 177 IEEE Transactions on Biomedical Engineering (TBME)
Millimeter-wave (MMW) induced heating can be potentially used to treat superficial skin cancer, including spreading melanoma. The aim of this work is to assess the cellular sensitivity of the A375 melanoma cell line to continuous MMW (58.4 GHz) induced heating between 37 and 47°C. Phosphorylation of heat shock protein 27 (HSP27) was used as a marker of the heat- induced cellular stress. Numerical and experimental electromagnetic and thermal dosimetry were carried out in detail to guarantee the correct interpretation of the biological outcomes. Results obtained may contribute to the design and optimization of clinical thermal treatment of superficial melanoma. read more