high-intensity focused ultrasound

Acoustic beam mapping for guiding HIFU therapy in vivo using sub-therapeutic sound pulse and passive beamforming

Acoustic beam mapping for guiding HIFU therapy in vivo using sub-therapeutic sound pulse and passive beamforming IEEE Transactions on Biomedical Engineering (TBME)
This work aims at deriving the therapeutic energy distribution within the tissue at the pre-treatment stage to guide the HIFU procedure. A beamforming-based energy mapping technique was established to estimate in-situ beam path of the therapeutic energy in a non-invasive way, which is extremely useful in visualizing the sound beam, especially its focal region, for the HIFU surgery. Effectiveness of this technique has been validated with simulations, in-vitro experiments, ex-vivo experiments and in-vivo tests on a rabbit. The technique is safe, easy to be applied in clinical practices, and can potentially be adapted to other ultrasound-related beam manipulating applications. read more

Learning Multiparametric Biomarkers for Assessing MR-Guided Focused Ultrasound Treatment of Malignant Tumors

Author(s): Blake Zimmerman, Sara Johnson, Henrik Odéen, Jill Shea, Markus D. Foote, Nicole Winkler, Sarang Joshi, Allison Payne
Learning Multiparametric Biomarkers for Assessing MR-Guided Focused Ultrasound Treatment of Malignant Tumors 170 177 IEEE Transactions on Biomedical Engineering (TBME)
A significant challenge for noninvasive MR-guided focused ultrasound (MRgFUS) treatment is assessing the viability of treated tissue during and immediately after MRgFUS procedures. Current clinical assessment uses contrast agents that prevent continuing MRgFUS treatment if tumor coverage is inadequate. This work presents a novel, noncontrast, learned multiparametric MR biomarker that can be used during treatment for iterative assessment with inhibiting treatment continuation. Trained using a novel volume-conserving registration algorithm, the presented noncontrast biomarker outperformed the current clinical standard on a VX2 rabbit tumor model. Details on the registration and deep learning model are included. read more

A breast-specific MR guided focused ultrasound platform and treatment protocol: first-in-human technical evaluation

Author(s): Allison Payne, Robb Merrill, Emilee Minalga, J. Rock Hadley, Henrik Odéen, Lorne W. Hofstetter, Sara Johnson, Christine Tunon de Lara, Sophie Auriol, Stephanié Recco, Erik Dumont, Dennis L. Parker, Jean Palussiere
A breast-specific MR guided focused ultrasound platform and treatment protocol: first-in-human technical evaluation 176 170 IEEE Transactions on Biomedical Engineering (TBME)
Breast cancer remains one of the most common cancers among women. The development of novel technology for minimally-invasive treatments will provide important new treatment options for many breast cancer patients. This work presents a breast-specific magnetic resonance (MR) guided focused ultrasound system for the treatment of localized breast tumors. The unique design of the system allows for high quality MR images for treatment planning and assessment, target accuracy determination with volumetric magnetic resonance-acoustic radiation force imaging, and real time treatment monitoring with magnetic resonance thermometry. Technical specification for the system are provided as well as preliminary results from a first-in-human clinical trial. read more

Real-Time Photoacoustic Thermometry Combined with Clinical Ultrasound Imaging and High-Intensity Focused Ultrasound

Author(s): Jeesu Kim, Wonseok Choi, Eun-Yeong Park, Youngnam Kang, Ki Jong Lee, Hyung Ham Kim, Won Jong Kim, Chulhong Kim
Real-Time Photoacoustic Thermometry Combined with Clinical Ultrasound Imaging and High-Intensity Focused Ultrasound 170 177 IEEE Transactions on Biomedical Engineering (TBME)

        High intensity focused ultrasound (HIFU) treatment is a promising non-invasive method for killing or destroying the diseased tissues by locally delivering thermal and mechanical energy without damaging surrounding normal…

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