focused ultrasound

Comparison of sonication patterns and microbubble administration strategies for focused ultrasound-mediated large-volume drug delivery

Comparison of sonication patterns and microbubble administration strategies for focused ultrasound-mediated large-volume drug delivery

Comparison of sonication patterns and microbubble administration strategies for focused ultrasound-mediated large-volume drug delivery 1044 594 IEEE Transactions on Biomedical Engineering (TBME)
This study compared different sonication patterns and microbubble administration strategies and identified the approach to achieve efficient, homogeneous, and safe large volume blood-brain barrier opening at the brainstem of mice. read more

Implementation of a Skull-Conformal Phased Array for Transcranial Focused Ultrasound Therapy

Author(s): Chris Adams, Ryan M. Jones, Steven D. Yang, Wai Meng Kan, Kogee Leung, Yuheng Zhou, Kang Uk Lee, Yuexi Huang, Kullervo Hynynen
Implementation of a Skull-Conformal Phased Array for Transcranial Focused Ultrasound Therapy 170 177 IEEE Transactions on Biomedical Engineering (TBME)
This work aims to improve on the patient comfort and reduce the reliance on intraoperative magnetic resonance image (MRI) guidance for transcranial focused ultrasound therapy. We present a technique for the automated design of a scaffold to house re-usable ultrasound transducers. The scaffold can be optimised for patient-specific brain targets and to conform to the patient’s head. We demonstrated the feasibility of our system by way of numerical simulations and in-vivo testing in rodents. Our results demonstrated that the device could achieve focus through the human skull and safely open the blood-brain-barrier. Skull-conformal phased arrays stand to improve patient comfort and have the potential to accelerate the adoption of transcranial FUS therapy by improving access to the technology. read more

Contrast-free detection of focused ultrasound-induced blood-brain barrier opening using diffusion tensor imaging

Author(s): Maria Eleni Karakatsani, Antonios Pouliopoulos, Michael Liu, Sachin R. Jambawalikar, Elisa E. Konofagou
Contrast-free detection of focused ultrasound-induced blood-brain barrier opening using diffusion tensor imaging 170 177 IEEE Transactions on Biomedical Engineering (TBME)
Karakatsani et al. report a contrast-free method to detect focused ultrasound (FUS)-induced blood-brain barrier (BBB) opening using diffusion tensor imaging (DTI). The localized BBB opening was hypothesized to result to a transient change in the diffusion pattern of water molecules and was tested in a non-human primate model, which closely resembled the human anatomy. They found that fractional anisotropy within the targeted area increased by 82% after the procedure, showing that DTI can confirm BBB opening without the use of contrast agents, increasing the safety of the methodology since contrast does not have to cross into the brain parenchyma. read more

A breast-specific MR guided focused ultrasound platform and treatment protocol: first-in-human technical evaluation

Author(s): Allison Payne, Robb Merrill, Emilee Minalga, J. Rock Hadley, Henrik Odéen, Lorne W. Hofstetter, Sara Johnson, Christine Tunon de Lara, Sophie Auriol, Stephanié Recco, Erik Dumont, Dennis L. Parker, Jean Palussiere
A breast-specific MR guided focused ultrasound platform and treatment protocol: first-in-human technical evaluation 176 170 IEEE Transactions on Biomedical Engineering (TBME)
Breast cancer remains one of the most common cancers among women. The development of novel technology for minimally-invasive treatments will provide important new treatment options for many breast cancer patients. This work presents a breast-specific magnetic resonance (MR) guided focused ultrasound system for the treatment of localized breast tumors. The unique design of the system allows for high quality MR images for treatment planning and assessment, target accuracy determination with volumetric magnetic resonance-acoustic radiation force imaging, and real time treatment monitoring with magnetic resonance thermometry. Technical specification for the system are provided as well as preliminary results from a first-in-human clinical trial. read more

Enhanced detection of bubble emissions through the intact spine for monitoring ultrasound-mediated blood-spinal cord barrier opening

Author(s): Stecia-Marie Fletcher, Natalia Ogrodnik, Meaghan O’Reilly
Enhanced detection of bubble emissions through the intact spine for monitoring ultrasound-mediated blood-spinal cord barrier opening 170 177 IEEE Transactions on Biomedical Engineering (TBME)
Short burst, phase keying (SBPK) is a clinically relevant pulse scheme for focused ultrasound delivery to the spinal canal. We demonstrate that emissions from microbubbles exposed to these pulses can be detected through ex vivo human vertebrae, and that SBPK exposures can open the blood-spinal cord barrier (BSCB) in rats. Microbubbles were sonicated through ex vivo vertebrae and emissions were analyzed using short time Fourier analysis. Pulses were modified to include pulse inversion, which enhanced detection of acoustic signatures. In rats, opening was confirmed by MRI enhancement. Detection of the subharmonic was linked to tissue damage observed at histology. read more
Self-scanned HIFU ablation of moving tissue using real-time hybrid US-MR imaging

Self-scanned HIFU ablation of moving tissue using real-time hybrid US-MR imaging

Author(s): Orane Lorton, Pauline Guillemin, Nadia Mori, Lindsey Alexandra Crowe, Sana Boudabbous, Sylvain Terraz, Christoph Becker, Philippe C. Cattin, Rares Salomir, Laura Gui
Self-scanned HIFU ablation of moving tissue using real-time hybrid US-MR imaging 177 170 IEEE Transactions on Biomedical Engineering (TBME)

          High Intensity Focused Ultrasound (HIFU) treatment in the abdominal cavity is challenging due to the respiratory motion. In the self-scanning HIFU ablation method the focal spot is kept static…

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