Electroporation Microchip With Integrated Conducting Polymer Electrode Array for Highly Sensitive Impedance Measurement
IEEE Transactions on Biomedical Engineering (TBME)
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An in vitro platform is presented that monitors the degree of electroporation while cells are treated with pulsed electric fields. The developed electroporation chip can assess the integrity of a monolayer of cells by performing electrochemical impedance spectroscopy with microelectrodes. The sensitivity of the system is significantly enhanced by reducing the impedance of the sensing electrodes which is achieved by applying a PEDOT:PSS coating. The integrated system of sensing and stimulation electrodes provides feedback on treatment progression and can be used to study electroporation dynamics.
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