drug delivery

A Novel Capsule-Delivered Enteric Drug-Injection Device for Delivery of Systemic Biologics: A Pilot Study in a Porcine Model

Author(s): Sunandita Sarker, Ben Wankum, Jeff Shimizu, Ryan Jones, Benjamin Terry
A Novel Capsule-Delivered Enteric Drug-Injection Device for Delivery of Systemic Biologics: A Pilot Study in a Porcine Model IEEE Transactions on Biomedical Engineering (TBME)
Here, we report a swallowable capsule for intestinal drug delivery (SCIDD) with the potential of directly injecting biological therapeutics into the small intestine wall. The design, optimization, and validation of the SCIDD’s primary subsystems were performed both ex-vivo and in-vivo. The assembled capsule was further tested in vivo to validate the actuation sequence which showed a 70% success rate in an animal model. A drug delivery study indicated systemic uptake of adalimumab via SCIDD compared with luminal delivery in the small intestine. The pilot study presented here establishes that the novel platform could be used to orally deliver systemic biologics. read more

A factorial approach for optimizing the design parameters of a tissue attachment mechanism for drug delivery

Author(s): Sunandita Sarker, Ben Wankum, Jeff Shimizu, Ryan Jones, Benjamin Terry
A factorial approach for optimizing the design parameters of a tissue attachment mechanism for drug delivery 709 738 IEEE Transactions on Biomedical Engineering (TBME)
In this work, a tissue attachment mechanism (TAM) was designed, optimized, and validated for a drug delivery ingestible capsule robot with a straightforward and mass-producible fabrication process. For the first time with this type of device, an optimization process was conducted on live tissue incorporating the dynamic nature of tissue response, and an attachment success rate of 92% was achieved. The duration test in a live and mobile large animal model showed a consistent and reliable attachment duration of over 30 hours, making the TAM a suitable candidate for a 24-hour long systemic drug delivery platform. read more

Electric Stimulus-Responsive Chitosan/MNP composite Microbeads for a Drug Delivery System

Author(s): Ankita Mohapatra, Carlos Wells, Amber Jennings, Madhay Ghimire, Sanjay R. Mishra, Bashir I. Morshed
Electric Stimulus-Responsive Chitosan/MNP composite Microbeads for a Drug Delivery System 170 177 IEEE Transactions on Biomedical Engineering (TBME)

Direct drug administration has several shortcomings, for eg, poor target localization and specificity, opsonization, undesired systemic exposure, etc. Stimuli controlled Drug Delivery Substrates (DDS) not only sterically shield the drug…

read more