DCIS modeling

A multiscale agent-based model of ductal carcinoma in situ

Author(s): Joseph D. Butner, David Fuentes, Bulent Ozpolat, George A. Calin, Xiaobo Zhou, John S. Lowengrub, Vittorio Cristini, Zhihui Wang
A multiscale agent-based model of ductal carcinoma in situ 170 176 IEEE Transactions on Biomedical Engineering (TBME)
Breast cancer is the most frequently diagnosed cancer in the United States, and about 17% of these occur within the mammary gland duct, known as ductal carcinoma in situ (DCIS). We have developed a multiscale, lattice-free agent-based model of DCIS, incorporating both molecular and cellular scales, to study how phenotypic and signaling changes influence the key early stages of disease development. By simulating the effects of bidirectional feedback between these scales, we have gained valuable insights into how this complex interplay affects disease progression, and have identified key processes that may be optimal prognostic indicators of future disease advancement. read more