bionic

STEER: 3D Printed Guide for Nerve Regrowth Control and Neural Interface in Non-Human Primate Model

Author(s): Agata Blasiak, Kian Ann Ng, Marshal Dian Sheng Wong, Chne-Wuen Tsai, Astrid Rusly, Gil Gerald Lasam Gammad, Kai Voges, Camilo Libedinsky, Shih Cheng Yen, Nitish V. Thakor, Amitabha Lahiri
STEER: 3D Printed Guide for Nerve Regrowth Control and Neural Interface in Non-Human Primate Model 461 480 IEEE Transactions on Biomedical Engineering (TBME)
Our work aims to address the challenging problem of reactive-fibrosis in establishing a long term peripheral neural interface (PNI). We present a novel interface – STEER PNI – that harnessed the fibro-axonal growth from the nerve and incorporated fibrosis in its design. STEER PNI consists of a synthetic guide that steers fibro-axonal growth toward encapsulation of the electrodes incorporated within the guide itself. We validated the functionality of this interface in macaques with electrophysiology and immunohistochemistry. This design provides a practical approach for creating long term neural interfaces with applications in neuro-prosthetics and beyond. read more