IEEE Transactions on

Biomedical Engineering

IEEE Transactions on Biomedical Engineering contains basic and applied papers dealing with biomedical engineering. Papers range from engineering development in methods and techniques with biomedical applications to experimental and clinical investigations with engineering contributions.

Editor-in-Chief

Xiaochuan Pan

Xiaochuan Pan

Xiaochuan Pan is currently Professor of Radiology, Radiation & Cellular Oncology, Committee in Medical Physics, the College, and the University of Chicago Medicine Comprehensive Cancer Center at The University of Chicago. He received the BS (1982) and MS (1985) degrees in physics from Beijing University and the Institute of Physics, Science Academy of China and the MS (1988) and PhD (1991) degrees in physics from The University of Chicago. Following post-doc training in medical imaging from 1992-1994 in the Department of Radiology at The University of Chicago, he was appointed as an Assistant Professor of Radiology before being promoted to Associate Professor and Professor of Radiology in 2001 and 2006.

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Featured Articles

Knock-in of a Large Reporter Gene via the High-Throughput Microinjection of the CRISPR/Cas9 System 780 435 IEEE Transactions on Biomedical Engineering (TBME)

Knock-in of a Large Reporter Gene via the High-Throughput Microinjection of the CRISPR/Cas9 System

This work demonstrates the microinjection of CRISPR/Cas9 with an enhanced green fluorescent protein (GFP) donor template into single HepG2 cells can achieve reporter gene knock-in targeting the adeno-associated virus site 1 locus. Homology-directed repair-mediated knock-in can be observed with an efficiency of 41%. Assessment via T7E1 assay indicates that the GFP knock-in cells exhibit no detectable changes at potential off-target sites. A case study of injecting the GFP knock-in cells into zebrafish (Danio rerio) embryos to form an in vivo tumor model is conducted. Results demonstrate the efficiency of combining microinjection with the CRISPR/Cas9 system in achieving gene knock-in.

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MRI-Guided Cardiac RF Ablation for Comparing MRI Characteristics of Acute Lesions and Associated Electrophysiologic Voltage Reductions 2560 1427 IEEE Transactions on Biomedical Engineering (TBME)

MRI-Guided Cardiac RF Ablation for Comparing MRI Characteristics of Acute Lesions and Associated Electrophysiologic Voltage Reductions

This study characterizes permanent and transient injury caused by cardiac RF ablation in a preclinical model. Native-contrast MRI features of ablation were investigated in relation to catheter-based electrophysiologic (EP) signals inherently co-registered within the same coordinate frame, and histologically validated. Specifically, we show that bipolar voltage was reduced in the presence of both the permanent T1-derived RF lesion and transient T2-derived edema. These results suggest that these regions are distinct in native-contrast MRI, but not differentiable using bipolar voltage. Intraprocedural MRI visualization distinguishing transient and permanent injury could guide creation of more complete durable RF ablations, reducing arrhythmia recurrence.

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Quantification and 3D Localization of Magnetically Navigated Superparamagnetic Particles Using MRI in Phantom and Swine Chemoembolization Models 780 435 IEEE Transactions on Biomedical Engineering (TBME)

Quantification and 3D Localization of Magnetically Navigated Superparamagnetic Particles Using MRI in Phantom and Swine Chemoembolization Models

Author(s): Ning Li, Cyril Tous, Ivan P. Dimov, Dominic Cadoret, Phillip Fei, Yasamin Majedi, Simon Lessard, Zeynab Nosrati, Katayoun Saatchi, Urs O. Häfeli, An Tang, Samuel Kadoury, Sylvain Martel, Gilles…

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Estimating the neovascularity of human finger tendon through high-frequency ultrasound micro-Doppler imaging 780 435 IEEE Transactions on Biomedical Engineering (TBME)

Estimating the neovascularity of human finger tendon through high-frequency ultrasound micro-Doppler imaging

High-frequency micro-Doppler imaging (HFμDI) based on 40-MHz ultrafast ultrasound imaging was proposed for visualizing the neovascularization in injured finger tendons through block-wise singular value decomposition filtering and curvilinear structure enhancement. Small animal imaging experiments revealed that HFμDI provides excellent performance and the minimum vessel size was 35 μm without contrast agents. Neovascularization was clearly observed in injured finger tendons during the early phase of healing (weeks 11–21) and regressed from week 52-56. Neovascular density decreased by approximately 1.8%–8.0% after 4 weeks of rehabilitation. The experimental results indicate the potential of HFμDI for injured finger tendon evaluations.

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Improving the Energy Cost of Incline Walking and Stair Ascent with Ankle Exoskeleton Assistance in Cerebral Palsy 150 150 IEEE Transactions on Biomedical Engineering (TBME)

Improving the Energy Cost of Incline Walking and Stair Ascent with Ankle Exoskeleton Assistance in Cerebral Palsy

Author(s): Ying Fang, Greg Orekhov, Zachary F. Lerner

Graded walking terrains pose significant mobility challenges for individuals with movement disorders, including those with cerebral palsy (CP). We tested the ability of a novel battery-powered ankle exoskeleton to improve stair, incline, and real-world mixed-terrain walking in seven individuals with CP. Adaptive ankle assistance improved the energy cost of steady-state incline walking by 14% and stair ascent by 21% compared to walking without the device. This is the first study to demonstrate safety and performance benefits of ankle exoskeleton assistance on graded terrains in CP, and it encourages future studies to evaluate assistance on mixed-terrain walking in free-living environments.

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