March/April 2016

Feature March/April 2016
Blue Marble Game Company
Serious games are those designed for purposes other than mere entertainment. They have applications in many industries, including defense, education, and health care. Blue Marble Game Company of Altadena, California, has based its value proposition on a variant of this... Read more
Feature March/April 2016
Open Solutions to Healthcare Challenges
IEEE Pulse talks with Michael Wasser, co-founder of HealthSherpa and CEO of BloomAPI, about the changing landscape for electronic medical records, and the future of healthcare interoperability and innovation. IEEE Pulse: You have founded at least four companies already, correct? How... Read more
Feature March/April 2016
Creating a Computational Human Model
Imagine creating a new medical procedure that could revolutionize diagnosis or treatment of a long-standing human ailment, but being faced with restrictions in testing this procedure due to fears of exposing healthy humans to strong levels of radiation. In many... Read more
Cover Story March/April 2016
The Foundry: Scaling Up Biological Design
Above: Depicted, from left to right: Chris Voigt, Ben Gordon, Rob Nicol. Photo by Lillie Paquette / MIT School of Engineering. Living organisms are amazing feats of engineering: By following instructions encoded entirely in DNA, living systems can sense and respond to... Read more
Challenges and Opportunities, March/April 2016
Sleep Quality Assessment: Challenges and Opportunities
For a long time, sleep researchers have asked why we sleep and what are the physiological and mental needs which require sleep [1]. Today we understand that sleep is important for productivity, health, cognition, and well-being. As a consequence, physical... Read more
Feature March/April 2016
The drug development pipeline, once one of the most successful and lucrative commercial sectors in the United States, is now strained by a combination of factors: increased development costs, lengthy time lines, and the poor predictive power of preclinical studies,... Read more
Feature March/April 2016
The Clinical Utility of Circulating Tumor Cells
Clinicians have long sought rapid and accurate methods to screen for and track the progression of cancer. Current technologies include the use of blood tests to screen for certain biomarkers such as PSA level as an indication of prostate cancer... Read more
State of the Art March/April 2016
“Fate loves the fearless.” That was the fortune inside my wife’s fortune cookie that had been brought to her after a satisfying Chinese meal. How appropriate was that fortune days after the terrorist attack in Paris, France, in November 2015... Read more
Senior Design March/April 2016
Faculty Intellectual Property in Capstone Design Projects
A pinewood derby is a racing event for Cub Scouts, who, with the help of an adult, build their own cars out of wood. Parents, and occasionally other family members, help the Cub Scout design, carve, paint, add weights, and tune... Read more
Retrospectroscope March/April 2016
Could Al-Zahrawi Be Considered a Biomedical Engineer?
[accordion title=”Introducing Mohamed N. Saad”] By Max E. Valentinuzzi, I recently received an unexpected message from Mohamed N. Saad, out of Cairo, Egypt. Mohamed was submitting an article to be published in IEEE Pulse written about an Arab Muslim, known as Al-Zahrawi (936–1013),... Read more
Book Reviews March/April 2016
Technology: From Electromagnetic Modeling to Point-of-Care Using Consumer Electronics
Low-Frequency Electromagnetic Modeling for Electrical and Biological Systems Using MATLAB Edited by Sergey N. Makarov, Gregory M. Noetscher, and Ara Nazarian, Wiley, 2015. ISBN: 978-1-119-05256-2, 648 pages, US$150. The role of increasingly powerful computers in the modeling and simulation domain has resulted... Read more
Feature March/April 2016
Brain-Inspired Machines
In the computing community, people look at the brain as the ultimate computer. Brain-inspired machines are believed to be more efficient than the traditional Von Neumann computing paradigm, which has been the dominant computing model since the dawn of computing.... Read more
Feature March/April 2016
The Problem of False Discovery
Is there a Cheshire Cat in science? One might believe so, given the many published scientific discoveries that cannot be independently reproduced. The “replication crisis” in science has become a widely discussed issue among scientists and the lay media and... Read more
Feature March/April 2016
What Is the Distance Between Objects in a Data Set?
Digitally recorded data have become another critical natural resource in our current research environment. This reality is one of the tremendous victories for decades of research in computer engineering, computer science, electronics, and communications. While this scenario will continue to... Read more
Cover Story March/April 2016
Putting a Number on Pain
Will new technologies substantially change the way subjective complaints are measured in clinical trials, and, if so, by how much? Depending on the expert consulted, the answer ranges from a little to a lot. For decades, clinical trials that include so-called... Read more
Feature March/April 2016
New Trends in Clinical Trials
Technological advances, such as electronic data capture and the prevalence of Wi-Fi connectivity, are driving changes in how clinical trials are conducted and analyzed. As the power to track and analyze data expands, clinical trials are becoming more efficient and... Read more
Feature March/April 2016
The Engineer’s Take on Biology
Tom Knight may laugh when someone calls him the “godfather of synthetic biology,” but his ideas have helped spur a worldwide movement to look at biology with an engineer’s eye. Knight’s road to synthetic biology was not a straight shot. As... Read more
Feature March/April 2016
All It Takes Is Vision
Traditional genetic engineering has for several decades enabled the cutting and pasting of DNA from one place to another, allowing for all kinds of developments: giving bacteria the ability to make insulin, making crops pesticide- resistant, and increasing the size... Read more
Feature March/April 2016
Cell Break
In 2011, the California-based company Genomatica reported its success in rigging Escherichia coli microbes to convert sugar into the industrial chemical 1,4-butanediol (BDO). It was a feat of metabolic engineering: BDO is a key ingredient in the production of goods... Read more
Feature March/April 2016
The CRISPR Conundrum
We are in the midst of a CRISPR craze. The last five years have seen the publication of over 1,000 scientific papers, the allocation of millions of research dollars, and the establishment of four start-up companies in the United States alone. Internationally, the genome-editing market,... Read more
Feature January/February 2016, March/April 2016
PULSE On Stage: Electronic Health Records
The first IEEE PULSE On Stage event on electronic health records happened February 28th, 2016, in Las Vegas. Couldn’t Attend? See the Highlights Now Electronic health records (EHR) held the promise of allowing better, secure information sharing, and helping practitioners to provide... Read more
In Memoriam January/February 2016, March/April 2016
In Memoriam: Michael R. Neuman
Michael R. Neuman, M.D., Ph.D., former editor of IEEE Pulse Magazine and an IEEE Fellow, passed away on 18 February 2016. Michael Neuman was a friend and mentor to many, an accomplished researcher and academic as well as a dedicated... Read more
Challenges and Opportunities, January/February 2016, March/April 2016
Challenges in Patient-Specific Computer Simulations of Image-Guided Therapies
For many therapeutic interventions, imaging has become an essential component of initial diagnosis, as well as the monitoring of treatment progress and outcome. Imaging data can now be acquired in real-time, which has led to the emergence of image-guided interventions... Read more