November/December 2020

Spellchecking for the Story of Life With CRISPR-Cas9 and Base, Prime Editors

Author(s): Jim Banks
Spellchecking for the Story of Life With CRISPR-Cas9 and Base, Prime Editors 1000 640 IEEE Pulse
Just four letters—A, G, T, and C—make up the alphabet of the genome. It may seem simple, but a small difference in spelling can create mutations that result in life-threatening diseases. Gene variants that cause genetic diseases come in many varieties. Transition point mutations cause conditions such as progeria, the rapid aging disease. Transversion point mutations cause sickle-cell disease and other major disorders. Small insertions can cause Tay-Sachs, which stops nerves working properly and is usually fatal, and deletions can result in cystic fibrosis. read more