Non-Invasive Measurement of Elasticity in Glioblastoma Multiforme Validates Decreased TMZ Sensitivity in Astrocyte Co-Culture

Non-Invasive Measurement of Elasticity in Glioblastoma Multiforme Validates Decreased TMZ Sensitivity in Astrocyte Co-Culture 150 150 IEEE Open Journal of Engineering in Medicine and Biology (OJEMB)
Author(s): Megan Mendieta, Maryam Hatami, Manmohan Singh, Sajedeh Saeidi Fard, Mohammad Dehshiri, Alexander Schill, Dmitry Nevozhay, Salavat Aglyamov, Bulent Ozpolat, Konstantin V. Sokolov, Yasemin M. Akay, Kirill V. Larin, Metin Akay

Abstract:

Goal: In this research, we investigated the changes in elasticity of in vitro glioblastoma multiforme (GBM) spheroids when treated with the gold standard chemotherapy for GBM, Temozolomide (TMZ). Additionally, we aimed to use this alternative biomarker to assess how modifying the tumor microenvironment (TME) with the addition of human astrocytes (…

Published in: IEEE Open Journal of Engineering in Medicine and Biology
Page(s): 1 – 10
Year of Publication: 2025
Electronic ISSN: 2644-1276
DOI: 10.1109/OJEMB.2025.3528194
Publisher: IEEE

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