Featured Articles

Small-World Propensity Reveals the Frequency Specificity of Resting State Networks
Author(s)3: Michela Chiappalone, Gaia Bonassi, Mingqi Zhao, Jessica Samogin, Riccardo Iandolo, Laura Avanzino, Stefano Buccelli, Dante Mantini, Marianna Semprini, Federico Barban
Small-World Propensity Reveals the Frequency Specificity of Resting State Networks 800 585 IEEE Open Journal of Engineering in Medicine and Biology (OJEMB)

Functional connectivity (FC) is an important indicator of the brain’s state in different conditions, such as rest/task or health/pathology. Here we used high-density electroencephalography coupled to source reconstruction to assess…

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Modulating the Structure of Motor Variability for Skill Learning Through Specific Muscle Synergies in Elderlies and Young Adults
Author(s)3: Roy T. H. Cheung, Vincent C. K. Cheung, Xiao-Chang Zheng, Rosa H. M. Chan
Modulating the Structure of Motor Variability for Skill Learning Through Specific Muscle Synergies in Elderlies and Young Adults 800 600 IEEE Open Journal of Engineering in Medicine and Biology (OJEMB)

Motor variability – performance variations across task repetitions – has been assumed to be undesirable. But recent studies argue that variability facilitates early motor learning by allowing exploratory search of…

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On Error-Related Potentials During Sensorimotor-Based Brain-Computer Interface: Explorations With a Pseudo-Online Brain-Controlled Speller
Author(s)3: Jose del R. Millan, Michele Bevilacqua, Serafeim Perdikis
On Error-Related Potentials During Sensorimotor-Based Brain-Computer Interface: Explorations With a Pseudo-Online Brain-Controlled Speller 800 444 IEEE Open Journal of Engineering in Medicine and Biology (OJEMB)

Brain-computer interface (BCI) spelling is a promising communication solution for people in paralysis. Currently, BCIs suffer from imperfect decoding accuracy which calls for methods to handle spelling mistakes. Detecting error-related…

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Accelerometry-Based Digital Gait Characteristics for Classification of Parkinson’s Disease: What Counts?
Author(s)3: Silvia Del Din, Cameron Kirk, Lynn Rochester, Christopher Buckley, Maria Encarna Mico-Amigo, Claudia Mazza, Michael Dunne-Willows, Jian Quing Shi, Rana Zia Ur Rehman, Lisa Alcock
Accelerometry-Based Digital Gait Characteristics for Classification of Parkinson’s Disease: What Counts? 800 545 IEEE Open Journal of Engineering in Medicine and Biology (OJEMB)

Gait may be a useful biomarker that can be objectively measured with wearable technology to classify Parkinson’s disease (PD). This study aims to: (i) comprehensively quantify a battery of commonly…

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Predicting Lymphoma Development by Exploiting Genetic Variants and Clinical Findings in a Machine Learning-Based Methodology With Ensemble Classifiers in a Cohort of Sjögren’s Syndrome Patients
Author(s)3: Clio Mavragani, Konstantina D. Kourou, Costas Papaloukas, Michalis Voulgarelis, Andreas Goules, Dimitrios I. Fotiadis, Themis Exarchos, Andrianos Nezos, Eleni I. Georga, Vasileios C. Pezoulas, Athanasios G. Tzioufas, Haralampos M. Moutsopoulos
Predicting Lymphoma Development by Exploiting Genetic Variants and Clinical Findings in a Machine Learning-Based Methodology With Ensemble Classifiers in a Cohort of Sjögren’s Syndrome Patients 800 534 IEEE Open Journal of Engineering in Medicine and Biology (OJEMB)

Lymphoma development constitutes one of the most serious clinico-pathological manifestations of patients with Sjögren’s Syndrome (SS). Over the last decades the risk for lymphomagenesis in SS patients has been studied…

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Engineered Three-Dimensional Scaffolds Modulating Fate of Breast Cancer Cells Using Stiffness and Morphology Related Cell Adhesion
Author(s)3: Smitha Rao, Brennan J. Vogl, Carolynn A. Que, Samerender N. Hanumantharao
Engineered Three-Dimensional Scaffolds Modulating Fate of Breast Cancer Cells Using Stiffness and Morphology Related Cell Adhesion 348 358 IEEE Open Journal of Engineering in Medicine and Biology (OJEMB)
Artificially engineering the tumor microenvironment in vitro as a vital tool for understanding the mechanism of tumor progression. In this study, we developed three-dimensional cell scaffold systems with different topographical features and mechanical properties but similar surface chemistry. The cell behavior was modulated by the topography and mechanical properties of the scaffold. read more

Ultrasound Based Planning and Navigation for Non-Anatomical Liver Resections – An Ex-Vivo Study
Author(s)3: Daniel Candinas, Raluca-Maria Sandu, Federico Storni, Stefan Weber, Gian Andrea Prevost, Iwan Paolucci, Anja Lachenmayer, Luca Sahli
Ultrasound Based Planning and Navigation for Non-Anatomical Liver Resections – An Ex-Vivo Study 820 615 IEEE Open Journal of Engineering in Medicine and Biology (OJEMB)

Non-anatomical resections of liver tumors can be very challenging as the surgeon cannot use anatomical landmarks on the liver surface or in the ultrasound image for guidance. This makes it…

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Ultrasound Stimulations Induce Prolonged Depolarization and Fast Action Potentials in Leech Neurons
Author(s)3: Annarita Cutrone, Nicolo Meneghetti, Arianna Menciassi, Silvestro Micera, Francesca Dedola, Theo Lemaire, Alberto Mazzoni, Francesco Paolo Ulloa Severino, Andrea Cafarelli, Leonardo Ricotti
Ultrasound Stimulations Induce Prolonged Depolarization and Fast Action Potentials in Leech Neurons 800 345 IEEE Open Journal of Engineering in Medicine and Biology (OJEMB)

Ultrasound (US) stimulation carries the promise of a selective, reversible, and non-invasive modulation of neural activity without the need for genetic manipulation of neural structures. However, the mechanisms of US-induced…

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Temozolomide in Combination With NF-κB Inhibitor Significantly Disrupts the Glioblastoma Multiforme Spheroid Formation
Author(s)3: Naze G. Avci, Nitin Tandon, Yasemin M. Akay, Yoshua Esquenazi, Hui Xia, Jay-Jiguang Zhu, Metin Akay, Lisa H. Schmitt
Temozolomide in Combination With NF-κB Inhibitor Significantly Disrupts the Glioblastoma Multiforme Spheroid Formation 742 558 IEEE Open Journal of Engineering in Medicine and Biology (OJEMB)

Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor, accounting for 50% of all cases. GBM patients have a five-year survival rate of merely 5.6% and a median…

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