XAI-Based Assessment of the AMURA Model for Detecting Amyloid–β and Tau Microstructural Signatures in Alzheimer’s Disease

Abstract:

Objective: Brain microstructural changes already occur in the earliest phases of Alzheimer’s disease (AD) as evidenced in diffusion magnetic resonance imaging (dMRI) literature. This study investigates the potential of the novel dMRI Apparent Measures Using Reduced Acquisitions (AMURA) as imaging markers for capturing such tissue modifications. Methods and procedures: …