Miniaturized helix antennas are integrated with drug reservoirs to function as RFID wireless tag sensors for real-time drug dosage monitoring. The general design procedure of this type of biomedical antenna sensors are proposed based on electromagnetic theory and finite element simulation. A cost effective fabrication process is utilized to encapsulate the antenna sensor within a bio-compatible package layer using PDMS material, and at the same time form a drug storage or drug delivery unit inside the sensor. The in-vitro experiment on two prototypes of antenna sensor-drug reservoir assembly have shown the ability to monitor the drug dosage by tracking antenna resonant frequency shift from 2.4GHz–2.5GHz ISM band with realized sensitivity of 1.27 l/MHz for transdermal drug delivery monitoring and 2.76 l/MHz sensitivity for implanted drug delivery monitoring.
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