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RFID Tag Helix Antenna Sensors for Wireless Drug Dosage Monitoring

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Illustration of the proposed real time drug delivery monitoring system. Utilizing the antenna drug dosage sensors, a smart phone can track the drug volume in multiple drug delivery devices.
Illustration of the proposed real time drug delivery monitoring system. Utilizing the antenna drug dosage sensors, a smart phone can track the drug volume in multiple drug delivery devices.

Miniaturized helix antennas are integrated with drug reservoirs to function as RFID wireless tag sensors for real-time drug dosage monitoring. The general design procedure of this type of biomedical antenna sensors are proposed based on electromagnetic theory and finite element simulation. A cost effective fabrication process is utilized to encapsulate the antenna sensor within a bio-compatible package layer using PDMS material, and at the same time form a drug storage or drug delivery unit inside the sensor. The in-vitro experiment on two prototypes of antenna sensor-drug reservoir assembly have shown the ability to monitor the drug dosage by tracking antenna resonant frequency shift from 2.4GHz–2.5GHz ISM band with realized sensitivity of 1.27 l/MHz for transdermal drug delivery monitoring and 2.76 l/MHz sensitivity for implanted drug delivery monitoring.
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Authors

See complete bios of the authors in the full version of this article.
H HuangH Huang
Mr. Huang is currently working towards a Ph.D. degree at the Department of Electrical and Computer Engineering, University of Texas at Austin, and is working as a research assistant at the Methodist Hospital Research Institute. His research interests include wireless medical telemetry and novel nano-electronic devices for healthcare applications.

P ZhaoP Zhao
Mr. Zhao is a Ph.D. candidate at the University of Texas at Austin. He obtained a B.S. degree in Electronic Engineering at Tsinghua University in 2013. His current research interests include biomedical instrumentation and high throughput screen enabled by microfluidic technology.

PY ChenPY Chen
Dr. Chen is a Research Scientist at Intellectual Venture Laboratories in Bellevue, Washington. He received his Ph.D. in Electrical and Computer Engineering from the University of Texas at Austin in 2013. His research interests include various topics in physical and wave electronics, including high frequency electronics, electromagnetism, active and passive antennas, metamaterials, plasmonics, nanophotonics, and vacuum/solid-state nanoelectronic devices.

Y RenY Ren
Dr. Ren is a professor and director of the Complex Engineered System Lab (CESL) at Tsinghua University. He holds 15 patents, and has authored or coauthored over 120 technical papers in Internet complexity, P2P network and wireless communication. His research interests include the complexity of the body area network, Internet information sharing, wireless extension of mobile terminals, architecture of IoT with the mobile gateways.

X LiuX Liu
Dr. Liu joined the Methodist Hospital Research Institute in 2010 to develop a nanoengineering core facility. His research focus is the development of silicon based nanotechnology platforms for prevention, diagnosis and treatment of human disease and his current interests include mass production of porous silicon particles, surface chemistry of porous silicon, nanowire theranostic platforms, multifunctional nanoparticles, and microfluidics devices for isolation and analysis of exosomes.

M FerrariM Ferrari
Mr. Ferrari is President and CEO of Houston Methodist Research Institute, where he holds the Ernest Cockrell Jr. Distinguished Endowed Chair. He is also the director of the Institute of Academic Medicine and executive vice president of Houston Methodist, and is president of The Alliance for NanoHealth in Houston.

Y HuY Hu
Dr. Hu is an assistant member of The Methodist Hospital Research Institute; he directs a nanomedicine research program focusing on the development of novel nanomaterials and nanodevices and their applications to biomarker detection.

D AkinwandeD Akinwande
Dr. Akinwande is currently an Assistant Professor with the University of Texas, Austin. He is a co-inventor of a high-frequency bondwire interconnect. He has been honored with several awards including the inaugural IEEE nano Geim and Novoselov Graphene Prize, the NSF CAREER award, the Army and DTRA Young Investigator awards, the 3M Nontenured Faculty Award, and others.

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