Analyzing Systolic–Diastolic Interval Interaction Characteristics in Diabetic Cardiac Autonomic Neuropathy Progression

This paper proposes an ECG based measure for analysing Cardiac autonomic Neuropathy (CAN) related alteration in the temporal synchronization of left ventricle function (i.e. Systolic-diastolic interval interaction (SDI)). The measure was validated in diabetic CAN progression using three subject groups i) without CAN (CAN-); ii) with early/subclinical  CAN (ECAN); and iii) with Definite/clinical CAN (DCAN).  Variability of the SDI measure, vSDITQ-RR, was found sensitive with CAN progression, which proves the effectiveness of ECG based SDI measures in CAN diagnosis.