This paper proposes an ECG based measure for analysing Cardiac autonomic Neuropathy (CAN) related alteration in the temporal synchronization of left ventricle function (i.e. Systolic-diastolic interval interaction (SDI)). The measure was validated in diabetic CAN progression using three subject groups i) without CAN (CAN-); ii) with early/subclinical CAN (ECAN); and iii) with Definite/clinical CAN (DCAN). Variability of the SDI measure, vSDITQ-RR, was found sensitive with CAN progression, which proves the effectiveness of ECG based SDI measures in CAN diagnosis.
Analyzing Systolic–Diastolic Interval Interaction Characteristics in Diabetic Cardiac Autonomic Neuropathy Progression https://www.embs.org/jtehm/wp-content/uploads/sites/17/2015/08/article-internal.png 780 582 IEEE Journal of Translational Engineering in Health and Medicine (JTEHM) //www.embs.org/jtehm/wp-content/uploads/sites/17/2022/06/ieee-jtehm-logo2x.png