This paper proposes an ECG based measure for analysing Cardiac autonomic Neuropathy (CAN) related alteration in the temporal synchronization of left ventricle function (i.e. Systolic-diastolic interval interaction (SDI)). The measure was validated in diabetic CAN progression using three subject groups i) without CAN (CAN-); ii) with early/subclinical CAN (ECAN); and iii) with Definite/clinical CAN (DCAN). Variability of the SDI measure, vSDITQ-RR, was found sensitive with CAN progression, which proves the effectiveness of ECG based SDI measures in CAN diagnosis.
