This mini-symposium is organized and provided by the IEEE-EMBS Technical Community on Cardiopulmonary Systems and Physiology-Based Engineering. Although there is almost a parity in the global population of women and men, outside of clinical trials it is uncommon to find sex-balanced samples of subjects in most research studies, and it is less likely to find a targeted analysis of sex-based differences in experimental outcomes. The objective of this session is to provide a series of research presentations that provide examples of sex-based differences in the structure and/or control of the cardiopulmonary system. At the completion of this mini-symposium, attendees should expect to have gained an increased understanding and appreciation of sex-based differences in cardiopulmonary structure and control, and if applicable, feel better motivated to include sex-based analyses in the design and implementation of their future research.