Tza-Huei Wang

Tza-Huei Wang, PhD, is a Professor in the Departments of Mechanical Engineering and Biomedical Engineering at the Johns Hopkins University and has a joint appointment in the Oncology Department of Johns Hopkins School of Medicine. He received his B.S. in Mechanical Engineering from National Taiwan University and Ph.D. in Mechanical Engineering from University of California, Los Angeles. His primary research focus is the development of new technologies and methods for molecular analysis of diseases and biomedical research via advances in micro- and nano-scale sciences. Over the past decade, Dr. Wang has participated in developments of single-molecule fluorescence spectroscopy, microfuidics and nanobiosensors for genetic and epigenetic biomarker-based diagnostics of cancer, infectious disease and an array of other diseases. He has taken the leading role in the development of quantum dot-fluorescence resonance energy transfer (QD-FRET) DNA nanosensor that has been applied to detect a variety of cancer biomarkers including point mutations, DNA methylation and gene copy number variations in clinical labs. He also pioneered the development of single molecule detection (SMD) technologies for biomarker screening. He accomplished single molecule analysis of circulating nucleic acids (CNA) in patient sera, demonstrating the potential of using CNA integrity as a marker in cancer diagnostics and post-therapeutics monitoring. His ability to bridge engineering innovations and clinical needs makes him uniquely qualified to be a PI or co-investigator of several national transnational research centers, including JHU Center of Cancer Nanotechnology Excellence (CCNE), Stand Up to Cancer (SU2C) Epigenetic Dream Team, and Center for POC Tests for Sexually Transmitted Diseases. Dr. Wang is an inventor of 15 patents, and has authored over 90 research articles and over 120 abstracts and oral presentations. He serves on the Editorial Boards of Biomicrofluidics, Journal of Laboratory Automation, Micro & Nano Letters and a guest editor for the Biosensors journal. He also serves on the Technical Committee for IEEE Nanotechnology Council. He received the NSF CAREER Award in 2006, CRS Jorge Heller Award in 2007, ASGR Excellence in Research Award in 2007, JALA Ten Award, and several Best Paper Awards in technical conferences and workshops.

Associated articles

JTEHM, Articles, Published Articles
National Institute of Biomedical Imaging and Bioengineering Point-of-Care Technology Research Network: Advancing Precision Medicine
This Article is Featured in the Special Issue NIH-IEEE POCT 2015 To advance the development of point-of-care technology (POCT), the National Institute of Biomedical Imaging and Bioengineering established the POCT Research Network (POCTRN), comprised of Centers that emphasize multidisciplinary partnerships and... Read more