Patrick L. Purdon

Patrick L. Purdon is with the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, MA.

Associated articles

TBME, Featured Articles
Computationally Efficient Algorithms for Sparse, Dynamic Solutions to the EEG Source Localization Problem
Electroencephalography (EEG) and magnetoencephalography noninvasively record scalp electromagnetic fields generated by cerebral currents, revealing millisecond-level brain dynamics useful for neuroscience and clinical applications. Estimating the currents that generate these fields, i.e., source localization, is an ill-conditioned inverse problem. Solutions to... Read more
TBME, Featured Articles
Robust Estimation of Sparse Narrowband Spectra from Neuronal Spiking Data
Characterizing the spectral properties of neuronal responses is an important problem in computational neuroscience as it provides insight into the spectral organization of the underlying functional neural processes. Although spectral analysis techniques are widely used in the analysis of noninvasive... Read more
TBME,
Computationally Efficient Algorithms for Sparse, Dynamic Solutions to the EEG Source Localization Problem
Estimating the currents that underlie the field potentials captured by electroencephalography (EEG), i.e., EEG source localization, is an ill-conditioned inverse problem. Existing solutions consider spatial continuity constraints, dynamic modeling, or sparsity constraints. The computational cost of combining these approaches, however, poses a challenge for practical applications. We propose a new computationally efficient EEG source localization method that employs spatial covariance estimation, state-space modeling, and sparsity-enforcing priors. We validate the performance of our method using both simulated and experimentally recorded EEG data. Our approach provides substantial performance improvements over existing methods and thereby facilitates practical applications in both neuroscience and medicine... Read more