John S. Lowengrub

J.S. Lowengrub is with the Department of Mathematics, the Department of Biomedical Engineering, the Center for Complex Biological Systems, and the Chao Comprehensive Cancer Center, University of California, 540H Rowland Hall, Irvine CA 92697.

Associated articles

TBME, Featured Articles
Multiscale Modeling of Glioblastoma Suggests that the Partial Disruption of Vessel/Cancer Stem Cell Crosstalk Can Promote Tumor Regression without Increasing Invasiveness
In glioblastoma, the crosstalk between vascular endothelial cells (VECs) and glioma stem cells (GSCs) has been shown to enhance tumor growth. We develop a hybrid continuum-discrete mathematical model and show that the VEC-GSC crosstalk increases both tumor size and GSC... Read more
TBME, Featured Articles
A multiscale agent-based model of ductal carcinoma in situ
Breast cancer is the most frequently diagnosed cancer in the United States, and about 17% of these occur within the mammary gland duct, known as ductal carcinoma in situ (DCIS). We have developed a multiscale, lattice-free agent-based model of DCIS, incorporating both molecular and cellular scales, to study how phenotypic and signaling changes influence the key early stages of disease development. By simulating the effects of bidirectional feedback between these scales, we have gained valuable insights into how this complex interplay affects disease progression, and have identified key processes that may be optimal prognostic indicators of future disease advancement... Read more