Special Issue on Augmented Reality for BioinformaticsIEEE EMBSIEEE EMBS//www.embs.org/wp-content/uploads/2023/02/ieee-embs-tag-tm-logo2x.png
In this issue, vol. 26, issue 6, June 2022, 5 papers are published related to the Special Issue on Augmented Reality for Bioinformatics. Please click here to view them, with…
Author(s)3: Yi Sun, Ioannis Kakkos, George K. Matsopoulos, Jingjia Yuan, Peng Qi, Yu Sun
Inferring the Individual Psychopathologic Deficits with Structural Connectivity in a Longitudinal Cohort of SchizophreniaIEEE EMBSIEEE EMBS//www.embs.org/wp-content/uploads/2023/02/ieee-embs-tag-tm-logo2x.png
The prediction of schizophrenia-related psychopathologic deficits is exceedingly important in the fields of psychiatry and clinical practice. However, objective association of the brain structure alterations to the illness clinical symptoms…
Performance Evaluation of Magnetic Resonance Coupling Method for Intra-Body Network (IBNet)IEEE EMBSIEEE EMBS//www.embs.org/wp-content/uploads/2023/02/ieee-embs-tag-tm-logo2x.png
The study presents magnetic resonance (MR) coupling as a promising method for the intra-body network (IBNet) by demonstrating effective signal transmission in the human body. A comparative performance evaluation revealed that the MR coupling exhibited a path loss (PL) of under 33 dB (at 13.56 MHz), which is lower than other methods (galvanic, capacitive, or RF). The angular orientation between the transmitter and receiver showed a minor variation (∆PL ≤ 0.62 dB) but moderate dependency on distance (0.05 dB/cm). Different postures did not affect the communication (∆PL ≤ 0.21 dB). Multi-nodal transmission using MR coupling also showed successful communication. read more
Author(s)3: Sunandita Sarker, Ben Wankum, Jeff Shimizu, Ryan Jones, Benjamin Terry
A Novel Capsule-Delivered Enteric Drug-Injection Device for Delivery of Systemic Biologics: A Pilot Study in a Porcine ModelIEEE EMBSIEEE EMBS//www.embs.org/wp-content/uploads/2023/02/ieee-embs-tag-tm-logo2x.png
Here, we report a swallowable capsule for intestinal drug delivery (SCIDD) with the potential of directly injecting biological therapeutics into the small intestine wall. The design, optimization, and validation of the SCIDD’s primary subsystems were performed both ex-vivo and in-vivo. The assembled capsule was further tested in vivo to validate the actuation sequence which showed a 70% success rate in an animal model. A drug delivery study indicated systemic uptake of adalimumab via SCIDD compared with luminal delivery in the small intestine. The pilot study presented here establishes that the novel platform could be used to orally deliver systemic biologics. read more
Simultaneous localized brain mild hyperthermia and blood-brain barrier opening via feedback-controlled transcranial MR-guided focused ultrasound and microbubblesIEEE EMBSIEEE EMBS//www.embs.org/wp-content/uploads/2023/02/ieee-embs-tag-tm-logo2x.png
We present a synergistic focused ultrasound-based brain drug delivery method for both spatiotemporally precise transcranial mild hyperthermia and simultaneous localized blood-brain barrier (BBB) opening. We demonstrated that with the presence of microbubbles, transcranial MR-guided focused ultrasound mild hyperthermia can be achieved at significantly reduced powers and prolonged BBB opening can be simultaneously achieved with hyperthermia sonications in a rodent model. No structural abnormality, edema, hemorrhage, or acute microglial activation was observed in the target region via MR imaging and histology. This study provides a new strategy for enhanced drug delivery in brain tissues with a high clinical translation potential. read more
Jet-Induced Tissue Disruption for Blood ReleaseIEEE EMBSIEEE EMBS//www.embs.org/wp-content/uploads/2023/02/ieee-embs-tag-tm-logo2x.png
Jet injectors use a high-speed fluid jet to pierce the skin, and can be used not only to deliver drugs, but also to release capillary blood, much like a lancet. This work provides new histological information about tissue disruption induced by a circular jet, a lancet-inspired slot-shaped jet, and a lancet prick. The slot-shaped jet caused shallower penetration with smaller wound volume but disrupted more vascular endothelium than the circular jet. The findings suggest that jet injection can be designed to release capillary blood in volumes similar to that of a lancet prick, and thus be useful in blood testing. read more
This work presents a safe and effective keyhole neurosurgery intra-operative planning framework for flexible neurosurgical robots. The framework is intended to support neurosurgeons during the intraoperative procedure to react to a dynamic environment. The proposed system integrates inverse reinforcement learning path planning algorithm, based on expert demonstrations, with a realistic, time-bounded simulator based on Position-based Dynamics simulation that mocks brain deformations due to catheter insertion and a simulated robotic system. Simulation results performed on a human brain dataset show that that the presented intra-operative steerable needle path planner is able to avoid anatomical obstacles while optimising surgical criteria. read more
Public Health Informaticshttps://www.embs.org/wp-content/uploads/2022/04/page-title-bg-newsletter-signup.jpg1920160IEEE EMBSIEEE EMBS//www.embs.org/wp-content/uploads/2023/02/ieee-embs-tag-tm-logo2x.png
In this issue, vol. 26, issue 5, May 2022, 1 paper is published related to the topic Public Health Informatics. Please click here to view it, with link in IEEE XPLORE. read more
In this issue, vol. 26, issue 5, May 2022, 2 papers are published related to the topic Bioinformatics. Please click here to view them, with link in IEEE XPLORE. read more
Medical InformaticsIEEE EMBSIEEE EMBS//www.embs.org/wp-content/uploads/2023/02/ieee-embs-tag-tm-logo2x.png
In this issue, vol. 26, issue 5, May 2022, 5 papers are published related to the topic Medical Informatics. Please click here to view them, with link in IEEE XPLORE. read more
