IEEE Open Journal of Engineering in Medicine and Biology

Featured Articles
Ultrasound Based Planning and Navigation for Non-Anatomical Liver Resections – An Ex-Vivo Study
Non-anatomical resections of liver tumors can be very challenging as the surgeon cannot use anatomical landmarks on the liver surface or in the ultrasound image for guidance. This makes it difficult to achieve negative resection margins (R0) and still preserve... Read more
Featured Articles
Temozolomide in Combination With NF-κB Inhibitor Significantly Disrupts the Glioblastoma Multiforme Spheroid Formation
Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor, accounting for 50% of all cases. GBM patients have a five-year survival rate of merely 5.6% and a median overall survival of 14.6 months with the “Stupp” regimen, 20.9... Read more
Featured Articles
Transport of Liposome Encapsulated Drugs in Voxelized Computational Model of Human Brain Tumors
There are many obstacles in the transport of chemotherapeutic drugs to tumor cells that lead to irregular and non-uniform uptake of drugs inside tumors. The study of these transport problems will help with accurate prediction of drug transport and optimizing... Read more
Featured Articles
Robust and Efficient Biomolecular Clustering of Tumor Based on p -Norm Singular Value Decomposition
High dimensionality has become a typical feature of biomolecular data. In this paper, a novel dimension reduction method named p-norm singular value decomposition (PSVD) is proposed to seek the low-rank approximation matrix to the biomolecular data. To enhance the robustness... Read more
Featured Articles
Modeling Contrast-Imaging-Assisted Optimal Targeted Drug Delivery: A Touchable Communication Channel Estimation and Waveform Design Perspective
To maximize the effect of treatment and minimize the adverse effect on patients, we propose to optimize nanorobots-assisted targeted drug delivery (TDD) for locoregional treatment of tumor from the perspective of touchable communication channel estimation and waveform design. The drug... Read more
Featured Articles
Use of Model Predictive Control and Artificial Neural Networks to Optimize the Ultrasonic Release of a Model Drug From Liposomes
The use of echogenic liposomes to deliver chemotherapeutic agents for cancer treatment has gained wide recognition in the last 20 years. Cancerous cells can develop multiple drug resistance (MDR), in part, due to the drop in concentration of chemotherapeutic agents... Read more
Featured Articles
OVarCall: Bayesian Mutation Calling Method Utilizing Overlapping Paired-End Reads
Detection of somatic mutations from tumor and matched normal sequencing data has become a standard approach in cancer research. Although a number of mutation callers have been developed, it is still difficult to detect mutations with low-allele frequency even in... Read more
Featured Articles
Molecular Communication Model for Targeted Drug Delivery in Multiple Disease Sites With Diversely Expressed Enzymes
Targeted drug delivery (TDD) for disease therapy using liposomes as nanocarriers has received extensive attention in the literature. The liposome’s ability to incorporate capabilities such as long circulation, stimuli responsiveness, and targeting characteristics, makes it a versatile nanocarrier. Timely drug... Read more
Featured Articles
Centrifugal Filter Device for Detection of Rare Cells With Immuno-Binding
Many investigations have shown circulating tumor cells (CTCs) to serve as a significant biomarker of cancer progression and for cancer treatment. Multiple blood samples detection of CTCs during a course of treatment might facilitate a choice by a medical doctor... Read more
Featured Articles
3D silicon microstructures: a new tool for evaluating biological aggressiveness of tumour cells
In this work, silicon micromachined structures (SMS), consisting of arrays of 3-µm-thick silicon walls separated by 50-µm-deep, 5-µm-wide gaps, were applied to investigate the behaviour of eight tumour cell lines, with different origins and biological aggressiveness, in a three-dimensional (3D)... Read more