IEEE Transactions on Biomedical Engineering

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Multimodal Imaging of Laser Speckle Contrast Imaging Combined with Mosaic Filter-Based Hyperspectral Imaging for Precise Surgical Guidance
The goal of this study is to develop a multi-modality imaging system combining visible, hyperspectral imaging (HSI), and laser speckle contrast imaging (LSCI) to guide surgical procedures for organ transplantation and resection. Resection sites are specified through high-resolution general imaging and LSCI, which makes blood perfusion observable without labels or contrast agents. Tissues are classified by HSI of hemodynamic biomarkers. The multimodal device is capable of monitoring oxygen saturation from the spectral changes characteristic of blood to detect thrombosis, perfusion, and hemorrhage. Based on these technologies, the risks to patients in the operating room can be minimized... Read more