Transactions on NanoBioscience
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3D silicon microstructures: a new tool for evaluating biological aggressiveness of tumour cells
Sabina Merlo, Giuliano Mazzini, Francesca Carpignano, Salvatore Surdo, Francesca Aredia, Martina Torchio, Eugenio Erba, Marco Danova, Anna Scovassi, Giuseppe Barillaro
In this work, silicon micromachined structures (SMS), consisting of arrays of 3-µm-thick silicon walls separated by 50-µm-deep, 5-µm-wide gaps, were applied to investigate the behaviour of eight tumour cell lines, with different origins and biological aggressiveness, in a three-dimensional (3D)...
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Posted on 10 DEC 2015
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Identification Exon Skipping Events From High-Throughput RNA Sequencing Data
The emergence of next-generation high-throughput RNA sequencing (RNA-Seq) provides tremendous opportunities for researchers to analyze alternative splicing on a genome-wide scale. However, accurate identification of alternative splicing events from RNA-Seq data has remained an unresolved challenge in next-generation sequencing (NGS)...
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Posted on 24 AUG 2015