IEEE Open Journal of Engineering in Medicine and Biology

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Ultrasound Stimulations Induce Prolonged Depolarization and Fast Action Potentials in Leech Neurons
Ultrasound (US) stimulation carries the promise of a selective, reversible, and non-invasive modulation of neural activity without the need for genetic manipulation of neural structures. However, the mechanisms of US-induced generation of action potentials (APs) are still unclear. Methods: Here... Read more
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Design and Test of a Biomechanical Model for the Estimation of Knee Joint Angle During Indoor Rowing: Implications for FES-Rowing Protocols in Paraplegia
Functional electrical stimulation of lower limb muscles during rowing provides a means for the cardiovascular conditioning in paraplegia. The possibility of shaping stimulation profiles according to changes in knee angle, so far conceived as changes in seat position, may help... Read more
Articles, Published Articles
Chest Compression Quality in a Newborn Manikin. A Randomized Crossover Trial
        Abstract The objective of this study was to examine changes in applied force and rate of chest compression (CC) during 5 min of CC with a target CC rate of 90/min (CC90) or 120/min (CC120) with and without metronome guidance during... Read more
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State Estimation for Discrete Time-Delayed Genetic Regulatory Networks With Stochastic Noises Under the Round-Robin Protocols
This paper investigates the problem of state estimation for discrete time-delayed genetic regulatory networks with stochastic process noises and bounded exogenous disturbances under the Round-Robin (RR) protocols. The network measurement outputs obtained by two groups of sensors are transmitted to... Read more
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HapIso: An Accurate Method for the Haplotype- Specific Isoforms Reconstruction From Long Single-Molecule Reads
Sequencing of RNA provides the possibility to study an individual’s transcriptome landscape and determine allelic expression ratios. Single-molecule protocols generate multi-kilobase reads longer than most transcripts, allowing sequencing of complete haplotype isoforms. This allows partitioning the reads into two parental... Read more
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A Molecular Communications Model for Drug Delivery
This paper considers the scenario of a targeted drug delivery system, which consists of deploying a number of biological nanomachines close to a biological target (e.g., a tumor), able to deliver drug molecules in the diseased area. Suitably located transmitters... Read more
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Optimizing the Electrical Stimulation of Retinal Ganglion Cells
Abstract Epiretinal prostheses aim to restore visual perception in the blind through electrical stimulation of surviving retinal ganglion cells (RGCs). While the effects of several waveform parameters (e.g., phase duration) on stimulation efficacy have been described, their relative influence remains unclear.... Read more
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Quantitative Evaluation of a Low-Cost Noninvasive Hybrid Interface Based on EEG and Eye Movement
Abstract This paper describes a low-cost noninvasive brain-computer interface (BCI) hybridized with eye tracking. It also discusses its feasibility through a Fitts’ law-based quantitative evaluation method. Noninvasive BCI has recently received a lot of attention. To bring the BCI applications into... Read more