Transactions on NanoBioscience
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Principles of Information Storage in Small-Molecule Mixtures
Christopher Rose, Jason Sello, Shui Ling Chen, Eamonn Kennedy, Joseph Geiser, Amanda Dombroski, Eunsuk Kim, Kady Oakley, Brenda M. Rubenstein, Hokchhay Tann, Peter M. Weber, Christopher Arcadia, Jacob K. Rosenstein, Sherief Reda
Molecular data systems have the potential to store information at dramatically higher density than existing electronic media. Some of the first experimental demonstrations of this idea have used DNA, but nature also uses a wide diversity of smaller non-polymeric molecules...
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Posted on 10 MAR 2020
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State Estimation for Discrete Time-Delayed Genetic Regulatory Networks With Stochastic Noises Under the Round-Robin Protocols
This paper investigates the problem of state estimation for discrete time-delayed genetic regulatory networks with stochastic process noises and bounded exogenous disturbances under the Round-Robin (RR) protocols. The network measurement outputs obtained by two groups of sensors are transmitted to...
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Posted on 11 JUN 2018
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Biomolecular Network Controllability With Drug Binding Information
Complex networks are ubiquitous in nature. In biological systems, biomolecules interact with each other to form so-called biomolecular networks, which determine the cellular behaviors of living organisms. Controlling the cellular behaviors by regulating certain biomolecules in the network is one...
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Posted on 17 AUG 2017
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Detection of Glutathione by Glutathione-S-Transferase – Nanoconjugate Ensemble Electrochemical Device
This paper reports a novel electrochemical method for detection of Glutathione (GSH) using Glutathione-S-Transferase (GST) – ZnO composite nanoparticles to investigate the prospects of the method for detection of cancer at an early stage. The purified GST enzyme was bound...
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Posted on 30 JUL 2017
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PhosPred-RF: a novel sequence-based predictor for phosphorylation sites using sequential information only
Many recent efforts have been made for the development of machine learning based methods for fast and accurate phosphorylation site prediction. Currently, a majority of well-performing methods are based on hybrid information to build prediction models, such as evolutionary information,...
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Posted on 30 JUL 2017
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Abnormality Detection in Correlated Gaussian Molecular Nano-Networks: Design and Analysis
A nano-abnormality detection scheme (NADS) in molecular nano-networks is studied. This is motivated by the fact that early detection of diseases such as cancer plays a crucial role in their successful treatment. The proposed NADS is in fact a two-tier...
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Posted on 7 MAY 2017
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TargetM6A: Identifying N6-Methyladenosine Sites From RNA Sequences via Position-Specific Nucleotide Propensities and a Support Vector Machine
As one of the most ubiquitous post-transcriptional modifications of RNA, N6-methyladenosine ( m 6 A ) plays an essential role in many vital biological processes. The identification of m 6 A sites in RNAs is significantly important for both basic biomedical research and practical...
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Posted on 26 DEC 2016
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Comprehensive Reactive Receiver Modeling for Diffusive Molecular Communication Systems: Reversible Binding, Molecule Degradation, and Finite Number of Receptors
This paper studies the problem of receiver modeling in molecular communication systems. We consider the diffusive molecular communication channel between a transmitter nano-machine and a receiver nano-machine in a fluid environment. The information molecules released by the transmitter nano-machine into...
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Posted on 26 DEC 2016
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Identification of DNA-Binding Proteins by Combining Auto-Cross Covariance Transformation and Ensemble Learning
DNA-binding proteins play a pivotal role in various intra- and extra-cellular activities ranging from DNA replication to gene expression control. With the rapid development of next generation of sequencing technique, the number of protein sequences is unprecedentedly increasing. Thus it...
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Posted on 19 AUG 2016
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Optimizing Associative Experimental Design for Protein Crystallization Screening
The goal of protein crystallization screening is the determination of the main factors of importance to crystallizing the protein under investigation. One of the major issues about determining these factors is that screening is often expanded to many hundreds or...
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Posted on 16 MAY 2016