IEEE Transactions on Biomedical Engineering

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Ultra-high-resolution 3D optical coherence tomography reveals inner structures of human placenta-derived trophoblast organoids
Many pregnancy complications are assumed to have their pathophysiological roots in early stages of placentation. Hence, trophoblast research represents a pre-requisite to help preventing pregnancy disorders that endangers uncomplicated gestations and jeopardizes maternal/fetal wellbeing later in life. Recently established 3D trophoblast organoids (TB-ORG) advanced human placental research. However, gold standard methods for determining TB-ORG architectures lack imaging depth and/or are endpoint analyses. We addressed these problems with 3D optical coherence tomography (OCT). This work demonstrates for the first time that OCT resolves label-free inner structures of TB-ORG during cultivation and enables qualitative/quantitative assessment of their differentiation status without sample destruction... Read more
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Optical Coherence Tomography Guided Robotic Needle Insertion for Deep Anterior Lamellar Keratoplasty
Deep anterior lamellar keratoplasty (DALK) is a promising form of partial-thickness cornea transplantation, but its popular “big bubble” technique frequently fails due to difficulty controlling a needle insertion into the cornea. We addressed the surgeon challenges that reduce success rates by demonstrating an optical coherence tomography (OCT)-guided, robotically stabilized workstation for manually or automatically performing DALK needle insertions. In a study with cornea fellows, we found that OCT visualization versus the standard stereo microscope was a key enabler in manual attempts and that our automatic robotic method met or exceeded the performance of cornea fellows... Read more
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Optimized Automated Segmentation and 3D Reconstruction Using Intracoronary Optical Coherence Tomography
Real time segmentation and three-dimensional (3D) reconstruction of the coronary arteries is challenging and limited by the increased computational time of the developed computer-aided methods. We present a novel and time-efficient method for intracoronary lumen detection which produces 3D coronary... Read more
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Lumen Segmentation in Intravascular Optical Coherence Tomography Using Backscattering Tracked and Initialized Random Walks
Intravascular imaging using optical coherence tomography (OCT) is commonly used in interventional cardiology for proper diagnosis and surgical planning. OCT provides high-­‐resolution images for detailed investigation of atherosclerosis induced thickening of the lumen wall resulting in arterial blockage and triggering... Read more
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Glaucoma progression detection using structural retinal nerve fiber layer measurements and functional visual field points
Siamak Yousefi, Michael H. Goldbaum, Madhusudhanan Balasubramanian, Tzyy-Ping Jung, Robert N. Weinreb, Felipe A. Medeiros, Linda M. Zangwill, Jeffrey M. Liebmann, Christopher A. Girkin, and Christopher Bowd University of California San Diego, University of Memphis, New York University, University of Alabama Volume 61, Issue 4,... Read more