IEEE Transactions on Biomedical Engineering

Featured Articles
On-Chip Impedance Quantification of Parasitic Voltages During AC Electrokinetic Trapping
Monitoring the effectiveness and location of cell or particle trapping under microfluidic force fields is currently achieved by cumbersome imaging methods that require extensive microscopy to be conducted by a trained operator, with limited ability to rapidly trigger downstream decisions. We present an embedded circuit for an impedance sensor that directly interfaces to a microfluidic chip for the monitoring of cell or particle trapping based on the level and frequency response of parasitic voltage drops measured during AC electrokinetic manipulation, to enable assessment of trapping efficacy of the device geometry and to rapidly inform downstream cell separation decisions... Read more
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Epilepsy-on-a-chip System for Antiepileptic Drug Discovery
    Development of antiepileptic drugs is currently complicated by the long time course of epileptogenesis. This process occurs on a time scale of weeks to months in animal models, and takes up to two weeks in an in vitro organotypic hippocampal... Read more
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Paper-Based Membraneless Co-Laminar Microfluidic Glucose Biofuel Cell With MWCNT-Fed Bucky Paper Bioelectrodes
The present work establishes a membraneless, co-laminar flow-based approach to develop a cost-effective microfluidic paper-based analytical device for enzymatic biofuel cell (µPAD-EBFC). The developed µPAD-EBFC supporting the self-capillary fluid transport action, consists of Y-shaped paper microchannel with the fuel (glucose)... Read more
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Development of an On-Chip Antibiotic Permeability Assay With Single Molecule Detection Capability
Electrophysiology is the method of choice to characterize membrane channels. In this paper, we demonstrate a patch pipette based simple miniaturization that allows performing conductance measurements on a planar lipid bilayer in a microfluidic channel. Membrane proteins were reconstituted into... Read more
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Optimal Fungal Space Searching Algorithms
Previous experiments have shown that fungi use an efficient natural algorithm for searching the space available for their growth in micro-confined networks, e.g., mazes. This natural “master” algorithm, which comprises two “slave” sub-algorithms, i.e., collision-induced branching and directional memory, has... Read more
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Flexible Bioimpedance Sensor for Label-Free Detection of Cell Viability and Biomass
We introduce a flexible microfluidic bioimpedance sensor that is capable of detecting biomass and cell viability variations in a cell suspension. The sensor is developed on Indium Tin Oxide (ITO) coated Polyethylene terephthalate (PET) substrate and is devoid of gold,... Read more
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Nonlinear Dynamic Modelling of Platelet Aggregation via Microfluidic Devices
Miguel E. Combariza, Xinghuo Yu, Warwick S. Nesbitt, Arnan Mitchell, and Francisco J. Tovar-Lopez, RMIT University, Australia, Volume 62, Issue 7, Page: 1718-1727 The development of blood clots at sites of atherosclerotic plaque rupture -arterial thrombosis- remains a major cause of patient death... Read more
Featured Articles
Microfluidic-Assisted Fabrication of Flexible and Location Traceable Organo-Motor
In this paper, we fabricate a flexible and location traceable micro-motor, named organo-motor, assisted by microfluidic devices and with high throughput. The organo-motors are composed of organic hydrogel material, poly (ethylene glycol) diacrylate (PEGDA), which can provide the flexibility of... Read more
TBME 60th Anniversary
Toward Integrated Molecular Diagnostic System (iMDx): Principles and Applications
Seung-min Park, Andrew Sabour, Jun Ho Son, Sang Hun Lee, Luke Lee Stanford University & University of California, Berkeley, Volume 61, Issue 5, Page: 1506-1521 A new golden age in medicine will begin through the mass development of fully integrated, rapid, and remarkably accurate... Read more
Articles, Published Articles
Rapid, Affordable, and Point-of-Care Water Monitoring Via a Microfluidic DNA Sensor and a Mobile Interface for Global Health
Contaminated water is a serious concern in many developing countries with severe health consequences particularly for children. Current methods for monitoring waterborne pathogens are often time consuming, expensive, and labor intensive, making them not suitable for these regions. Electrochemical detection... Read more