IEEE Transactions on Biomedical Engineering

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Simultaneous localized brain mild hyperthermia and blood-brain barrier opening via feedback-controlled transcranial MR-guided focused ultrasound and microbubbles
We present a synergistic focused ultrasound-based brain drug delivery method for both spatiotemporally precise transcranial mild hyperthermia and simultaneous localized blood-brain barrier (BBB) opening. We demonstrated that with the presence of microbubbles, transcranial MR-guided focused ultrasound mild hyperthermia can be achieved at significantly reduced powers and prolonged BBB opening can be simultaneously achieved with hyperthermia sonications in a rodent model. No structural abnormality, edema, hemorrhage, or acute microglial activation was observed in the target region via MR imaging and histology. This study provides a new strategy for enhanced drug delivery in brain tissues with a high clinical translation potential... Read more