Transactions on NanoBioscience

Modeling of Anti-cancer Drug Release Kinetics from Liposomes and Micelles: A review
Nanocarriers, such as liposomes and micelles, were developed to enhance the delivery of therapeutic drugs to malignant tissues. Internal or external stimuli can be applied to achieve spatiotemporal controlled release from these carriers. This will result in enhancing their therapeutic... Read more
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A multiscale agent-based model of ductal carcinoma in situ
Breast cancer is the most frequently diagnosed cancer in the United States, and about 17% of these occur within the mammary gland duct, known as ductal carcinoma in situ (DCIS). We have developed a multiscale, lattice-free agent-based model of DCIS, incorporating both molecular and cellular scales, to study how phenotypic and signaling changes influence the key early stages of disease development. By simulating the effects of bidirectional feedback between these scales, we have gained valuable insights into how this complex interplay affects disease progression, and have identified key processes that may be optimal prognostic indicators of future disease advancement... Read more
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Abnormality Detection in Correlated Gaussian Molecular Nano-Networks: Design and Analysis
A nano-abnormality detection scheme (NADS) in molecular nano-networks is studied. This is motivated by the fact that early detection of diseases such as cancer plays a crucial role in their successful treatment. The proposed NADS is in fact a two-tier... Read more