IEEE Transactions on Biomedical Engineering

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Modeling of Interstitial Ultrasound Ablation for Continuous Applicator Rotation with MR Validation
Predictive modeling can play an important role in thermal ablative cancer treatments where estimated energy deposition may integrate into pre-operative planning software or combine with closed loop control. In this work, we develop a finite element model capable of simulating continuous rotation by a directional interstitial ultrasound applicator. The developed model simulates temperature maps for different rotation trajectories. The developed simulation was validated using magnetic resonance thermal imaging and demonstrated performance suitable for real-time control of robotically actuated conformal tumor ablation... Read more
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Laparoscopic Renal Denervation System for Treating Resistant Hypertension: Overcoming Limitations of Catheter-based Approaches
The radical sympathectomy and percutaneous catheter-based renal denervation (RDN) are two techniques proposed to treat life-threatening resistant hypertension. However, sympathectomy has been abandoned due to the procedure being too invasive, and RDN resulted in variation in blood pressure reduction between patients due to suboptimal denervation. Thus, a method to effectively ablate renal nerves while not being very invasive is needed to treat the resistant hypertension patients. Here we propose a minimally invasive Laparoscopic Denervation System (LDS) to serve this unmet clinical need. The LDS employs a direct renal nerve ablation technique while not imparting thermal arterial damage... Read more
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Micro-to-Nano Biomechanical Modeling for Assisted Biological Cell Injection
Hamid Ladjal, Jean-Luc Hanus, Antoine Ferreira Volume: 60, Issue: 9, Page: 2461-2471 Cell manipulation is a prevalent process in the field of molecular biology. This process plays an important role in intracytoplasmic sperm injection (ICSI), pronuclei deoxyribonucleic acid (DNA) injection, therapeutic and regenerative... Read more